Vagal reflexes following an exercise stress test: A simple clinical tool for gene-specific risk stratification in the long QT syndrome

Journal of the American College of Cardiology

Volumn 60, Issue 24, 2012, Pages 2515-2524

  Crotti, Lia ^a,b,c   Spazzolini, Carla ^b   Porretta, Alessandra P ^d   Dagradi, Federica ^a,b   Taravelli, Erika ^a,b   Petracci, Barbara ^b   Vicentini, Alessandro ^b   Pedrazzini, Matteo ^b   La Rovere, Maria Teresa ^e   Vanoli, Emilio ^a,f   Goosen, Althea ^g   Heradien, Marshall ^g   George Jr , Alfred L ^h   Brink, Paul A ^g   Schwartz, Peter J ^a,b,i,j  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d OSPEDALE SAN GIOVANNI   (Switzerland)

^e IRCCS   (Italy)

^f Clinica San Gaudenzio   (Italy)

^g STELLENBOSCH UNIVERSITY   (South Africa)

^h VANDERBILT UNIVERSITY   (United States)

ⁱ KING SAUD UNIVERSITY   (Saudi Arabia)

^j UNIVERSITY OF CAPE TOWN   (South Africa)

more..

Author keywords

autonomic nervous system; exercise testing; genetics; long QT syndrome; sudden death

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; POTASSIUM CHANNEL KCNQ1;

ADULT; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; EXERCISE INTENSITY; EXERCISE TEST; FEMALE; GENE DELETION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE PHENOTYPE CORRELATION; HEART RATE; HIGH RISK PATIENT; HUMAN; ITALY; LONG QT SYNDROME; LOW RISK POPULATION; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MOLECULAR PATHOLOGY; NONSENSE MUTATION; POTASSIUM CURRENT; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RISK ASSESSMENT; SOUTH AFRICA; SPLICING DEFECT; VAGUS REFLEX; WORKLOAD;

ADULT; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; MIDDLE AGED; RISK ASSESSMENT; VAGUS NERVE;

EID: 84871281671     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.08.1009     Document Type: Article

References (38)

1. P.J. Schwartz, M. Periti, A. Malliani The long Q-T syndrome Am Heart J 89 1975 378 390
2. P.J. Schwartz Idiopathic long QT syndrome: progress and questions Am Heart J 109 1985 399 411
3. P.J. Schwartz, L. Crotti, R. Insolia Long QT syndrome: from genetics to management Circ Arrhythm Electrophysiol 5 2012 868 877
4. P.J. Schwartz, M. Stramba-Badiale, L. Crotti Prevalence of the congenital long-QT syndrome Circulation 120 2009 1761 1767
5. + channel blockade and to increases in heart rate Implications for gene-specific therapy Circulation 92 1995 3381 3386
6. P.J. Schwartz, S.G. Priori, C. Spazzolini Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias Circulation 103 2001 89 95
7. L. Crotti, A.L. Lundquist, R. Insolia KCNH2-K897T is a genetic modifier of latent congenital long QT syndrome Circulation 112 2005 1251 1258
8. L. Crotti, M.C. Monti, R. Insolia NOS1AP is a genetic modifier of the long-QT syndrome Circulation 120 2009 1657 1663
9. M. Tomás, C. Napolitano, L. De Giuli Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome J Am Coll Cardiol 55 2010 2745 2752
10. P.J. Schwartz, A. Malliani Electrical alternation of the T wave Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long QT syndrome Am Heart J 89 1975 45 50
11. G. Malfatto, G. Beria, S. Sala, O. Bonazzi, P.J. Schwartz Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic long QT syndrome J Am Coll Cardiol 23 1994 296 301
12. F. Nador, G. Beria, G.M. De Ferrari Unsuspected echocardiographic abnormality in the long QT syndrome: diagnostic, prognostic, and pathogenetic implications Circulation 84 1991 1530 1542
13. K.H. Haugaa, T. Edvardsen, T.P. Leren, J.M. Gran, O.A. Smiseth, J.P. Amlie Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome Eur Heart J 30 2009 330 337
14. G.M. De Ferrari, P.J. Schwartz Long QT syndrome, a purely electrical disease? Not anymore Eur Heart J 30 2009 253 255
15. S.G. Priori, P.J. Schwartz, C. Napolitano Risk stratification in the long-QT syndrome New Engl J Med 348 2003 1866 1874
16. A.J. Moss, W. Shimizu, A.A. Wilde Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene Circulation 115 2007 2481 2489
17. P.J. Schwartz Sudden cardiac death, founder populations and mushrooms What is the link with gold mines and modifier genes? Heart Rhythm 8 2011 548 550
18. P.A. Brink, L. Crotti, V. Corfield Phenotypic variability and unusual clinical severity of congenital long QT syndrome in a founder population Circulation 112 2005 2602 2610
19. L. Crotti, C. Spazzolini, P.J. Schwartz The common long QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification Circulation 116 2007 2366 2375
20. P.J. Schwartz, E. Vanoli, L. Crotti Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome J Am Coll Cardiol 51 2008 920 929
21. M.T. La Rovere, P.J. Schwartz Baroreflex sensitivity D.P. Zipes, J. Jalife, Cardiac Electrophysiology. From Cell to Bedside 3rd edition 2000 WB Saunders Co. Philadelphia, PA 771 781
22. M.N. Levy, P.J. Schwartz Vagal Control of the Heart: Experimental Basis and Clinical Implications 1994 Futura Armonk, NY
23. K. Imai, H. Sato, M. Hori Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure J Am Coll Cardiol 24 1994 1529 1535
24. L.L. Smith, M. Kukielka, G.E. Billman Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction Am J Physiol Heart Circ Physiol 288 2005 H1763 H1769
25. G.E. Billman, M. Kukielka Effect of endurance exercise training on heart rate onset and heart rate recovery responses to submaximal exercise in animals susceptible to ventricular fibrillation J Appl Physiol 102 2007 231 240
26. P.J. Schwartz, S.G. Priori, C. Napolitano How really rare are rare diseases? The intriguing case of independent compound mutations in the long QT syndrome J Cardiovasc Electrophysiol 14 2003 1120 1121
27. P. Westenskow, I. Splawski, K.W. Timothy, M.T. Keating, M.C. Sanguinetti Compound mutations: a common cause of severe long-QT syndrome Circulation 109 2004 1834 1841
28. M. Hayashi, I. Denjoy, F. Extramiana Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia Circulation 119 2009 2426 2434
29. P.J. Schwartz, L. Crotti QTc behavior during exercise and genetic testing for the long-QT syndrome Circulation 124 2011 2181 2184
30. R.W. Sy, C. van der Werf, I.S. Chattha Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of LQTS probands Circulation 124 2011 2187 2194
31. S. Viskin, P.G. Postema, Z.A. Bhuiyan The response of the QT interval to the brief tachycardia provoked by standing: a bedside test for diagnosing long QT syndrome J Am Coll Cardiol 55 2010 1955 1961
32. C. Terrenoire, C.E. Clancy, J.W. Cormier, K.J. Sampson, R.S. Kass Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation Circ Res 96 2005 e25 e34
33. J. Silva, Y. Rudy Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve Circulation 112 2005 1384 1391
34. M.T. La Rovere, J.T. Bigger Jr., F.I. Marcus, A. Mortara, P.J. Schwartz ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction Lancet 351 1998 478 484
35. J. Tank, J. Jordan, A. Diedrich Genetic influences on baroreflex function in normal twins Hypertension 37 2001 907 910
36. P.J. Schwartz Management of the long QT syndrome Nat Clin Pract Cardiovasc Med 2 2005 346 351
37. G.E. Billman, P.J. Schwartz, H.L. Stone The effects of daily exercise on susceptibility to sudden cardiac death Circulation 69 1984 1182 1189
38. M.T. La Rovere, C. Bersano, M. Gnemmi, G. Specchia, P.J. Schwartz Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction Circulation 106 2002 945 949