Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation

European Journal of Pharmacology

Volumn 748, Issue , 2015, Pages 83-92

  Adage, Tiziana ^a   Konya, Viktoria ^b   Weber, Corinna ^a   Strutzmann, Elisabeth ^a   Fuchs, Thomas ^a   Zankl, Christina ^a   Gerlza, Tanja ^a   Jeremic, Dalibor ^a   Heinemann, Akos ^b   Kungl, Andreas J ^a,c  

^a ProtAffin Biotechnologie AG   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Chemokine; Glycosaminoglycan; Heparan sulfate; Inflammation; Neutrophils; Protein engineering

Indexed keywords

GLYCOSAMINOGLYCAN; INTERLEUKIN 8; SYNDECAN 4; BIOLOGICAL MARKER; LIPOPOLYSACCHARIDE; SMOKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE MARKER; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; DRUG TARGETING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; LUNG ENDOTHELIUM; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; PROTEIN ENGINEERING; PROTEIN EXPRESSION; ADVERSE EFFECTS; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; MICROVASCULATURE; MOLECULARLY TARGETED THERAPY; NEUTROPHIL CHEMOTAXIS; PROCEDURES; SMOKE; TOBACCO;

ANIMALS; BIOLOGICAL MARKERS; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GLYCOSAMINOGLYCANS; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICROVESSELS; MOLECULAR TARGETED THERAPY; NEUTROPHIL INFILTRATION; PNEUMONIA; PROTEIN ENGINEERING; SMOKE; SYNDECAN-4; TOBACCO;

EID: 84920695065     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.12.019     Document Type: Article

References (31)

1. T. Adage, A.M. Piccinini, A. Falsone, M. Trinker, J. Robinson, and B. Gesslbauer Structure-based design of decoy chemokines as a way to explore the pharmacological potential of gycosaminoglycans Br. J. Pharmacol. 167 2012 1195 1205
2. J. Bedke, P.J. Nelson, E. Kiss, N. Muenchmeier, A. Rek, and C.L. Behnes A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage Mol. Immunol. 47 5 2010 1047 1057
3. J.F. Chmiel, M. Berger, and M.W. Konstan The role of inflammation in the pathophysiology of CF lung disease Clin. Rev. Allergy Immunol. 23 1 2002 5 27
4. S.C. Cowburn, A.M. Condliffe, N. Farahi, C. Summers, and E.R. Chilvers Advances in neutrophil biology. Clinical implications Chest 134 2008 606 612
5. S.V. Culpitt, W. Maziak, S. Luokidis, J.A. Nightingale, J.L. Matthews, and P.J. Barnes Effects of high dose inhaled steroids on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 160 1999 1635 1639
6. A. Falsone, V. Wabitsch, E. Geretti, H. Potzinger, T. Gerlza, and J. Robinson Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo Biosci. Rep. 33 5 2013 743 7 54
7. M.F. Fitzgerald, and J.C. Fox Emerging trends in the therapy of COPD: novel anti-inflammatory agents in clinical development Drug Discov. Today 12 11/12 2007 479 485
8. S.D. Freedman, D. Weinstein, P.G. Blanco, P. Martinez-Clark, S. Urman, M. Zaman, J.D. Morrow, and J.G. Alvarez Characterization of LPS-induced lung inflammation in cftr-/- mice and effect of docosahexaenoic acid J. Appl. Physiol. 92 2002 2169 2176
9. S. Gill, T.N. Wight, and C.W. Frevert Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection Anat. Rec. 293 2010 968 981
10. B. Goger, Y. Halden, A. Rek, R. Mösl, D. Pye, and J. Gallagher Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites Biochemistry 41 2002 1640 1646
11. T. Gerlza, B. Hecher, D. Jeremic, T. Fuchs, M. Gschwandtner, and A. Falsone A combinatorial approach to biophysically characterise chemokine-glycan binding affinities for drug development Molecules 19 2014 10618 10634
12. O. Holz, S. Khalilieh, A. Ludwig-Sengpiel, H. Watz, P. Stryszak, and P. Soni SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects Eur. Respir. J. 35 2010 564 570
13. V. Kim, T.J. Rogers, and G.J. Criner New concepts in the pathology of chronic obstructive pulmonary disease Proc. Am. Thorac. Soc. 5 2008 478 485
14. A.L. Lazaar, L.E. Sweeney, A.J. MacDonald, N.E. Alexis, C. Chen, and R. Tal-Singer SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans Br. J. Clin. Pharmacol. 72 2011 282 293
15. D.A. Mahler, S. Huang, M. Tabrizi, and G.M. Bell Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study Chest 126 2004 926 934
16. P.A. Martorana, R. Beume, M. Lucattelli, L. Wollin, and G. Lungarella Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke Am. J. Respir. Crit. Care Med. 172 2005 848 853
17. R.B. Moss, S.J. Mistry, M.W. Konstan, J.M. Pilewski, E. Kerem, and R. Tal-Singer Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patient with cystic fibrosis J. Cyst. Fibros. 12 3 2013 241 248
18. N. Mukaida Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases Am. J. Physiol. Lung Cell. Mol. Physiol. 284 2003 L566 L577
19. R.E. Nocker, D.F. Schoonbrood, E.A. van de Graaf, C.E. Hack, R. Lutter, and H.M. Jansen Interleukin-8 in airway inflammation in patients with asthma and chronic obstructive pulmonary disease Int. Arch. Allergy Immunol. 109 1996 183 191
20. R.A. Peleman, P.H. Rytila, J.C. Kips, G.S. Joos, and R.A. Pauwels The cellular composition of induced sputum in chronic obstructive pulmonary disease Eur. Respir. J. 13 1999 839 843
21. U. Papakonstantinou, and G. Karakiulakis The 'sweet' and the 'bitter' involvement of glycosaminoglycans in lung diseases: pharmacotherapeutic relevance Br. J. Pharmacol. 157 2009 1111 1127
22. O. Soehnlein, A. Zemecke, E.E. Eriksson, A.G. Rothfuchs, C. Pham, and H. Herward Neutrophil secretion pave the way for inflammatory monocytes Blood 112 2008 1461 1471
23. D. Sparrow, R.J. Glynn, M. Cohen, and S.T. Weiss The relationship of the peripheral leukocyte count and cigarette smoking to pulmonary function among adult men Chest 86 1984 383 386
24. O. Tabary, H. Corvol, E. Boncoeur, K. Chadelat, C. Fitting, and J.M. Cavaillon Adherence of airway neutrophils and inflammatory response are increased in CF airway epithelial cell-neutrophil interactions Am. J. Physiol. Lung Cell. Mol. Physiol. 290 3 2006 L588 L596
25. M. Tanino, T. Betsuyaku, K. Takeyabu, Y. Tanino, E. Yamaguchi, and K. Miyamoto Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema Thorax 57 2002 405 411
26. Y. Tanino, D.R. Coombe, S.E. Gill, W.C. Kett, O. Kajikawa, and A.E.I. Proudfoot Kinetics of Chemokine-Glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs J. Immunol. 184 5 2010 2677 2685
27. T.H. Thatcher, N.A. McHugh, R.W. Egan, R.W. Chapman, J.A. Hey, and C.K. Turner The role of CXCR2 in cigarette smoke-induced lung inflammation Am. J. Physiol. Lung Cell. Mol. Physiol. 289 2 2005 L322 L328
28. C.M. Todd, D.M. Murphy, R.M. Watson, K. Howie, T.X. Srinich, and K. Peng Treatment with the CXCR2 antagonist SCH527123 reduced neutrophil levels in blood and airways but not bone marrow in mild asthmatic subjects Am. J. Respir. Crit. Care Med. 181 2010 A4237
29. R. Virtala, A.K. Ekman, L. Jansson, U. Westin, and L.O. Cardell Airway inflammation evaluated in human nasal lypopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor Clin. Experim. Allergy 42 2012 590 596
30. C. Whittall, O. Kehoe, S. King, A. Rot, A. Patterson, and J. Middleton A chemokine self-presentation mechanism involving formation of endothelial surface microstructures J. Immunol. 190 2013 1725 1736
31. I.S. Woolhouse, D.L. Bayley, and R.A. Stockley Sputum chemotactic activity in chronic obstructive pulmonary disease. Effects of a1-antitrypsin deficiency and the role of leukotriene B4 and interleukine 8 Thorax 57 2002 709 714