Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo

Bioscience Reports

Volumn 33, Issue 5, 2013, Pages 743-754

  Falsone, Angelika ^a   Wabitsch, Veronica ^a   Geretti, Elena ^b   Potzinger, Heide ^b   Gerlza, Tanja ^a   Robinson, James ^a   Adage, Tiziana ^a   Teixeira, Mauro M ^c   Kungl, Andreas J ^a,b  

^a ProtAffin Biotechnologie AG   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Anti inflammatory; Chemokine decoys; Competition; GAG affinity; Heparan sulphate

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLYCOSAMINOGLYCAN; INTERLEUKIN 8; MUTANT PROTEIN; ANTIINFLAMMATORY AGENT; CHEMOKINE RECEPTOR CXCR1; GUANIDINE; HEPARAN SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN STABILITY; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; C57BL MOUSE; CATTLE; CHEMISTRY; DRUG SCREENING; GENETICS; HUMAN; MALE; PROTEIN BINDING; PROTEIN DENATURATION; RHEUMATOID ARTHRITIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; BINDING SITES; CATTLE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GUANIDINE; HEPARITIN SULFATE; HUMANS; INTERLEUKIN-8; MALE; MICE; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN DENATURATION; RECEPTORS, INTERLEUKIN-8A;

EID: 84884859496     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130069     Document Type: Article

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