A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

Molecular Immunology

Volumn 47, Issue 5, 2010, Pages 1047-1057

  Bedke, Jens ^a   Nelson, Peter J ^b   Kiss, Eva ^a   Muenchmeier, Niklas ^b   Rek, Angelika ^c   Behnes, Carl Ludwig ^a   Gretz, Norbert ^d   Kungl, Andreas J ^c   Gröne, Hermann Josef ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c ProtAffin Biotechnologie AG   (Austria)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acute rejection; Chemokine; CXCL8; Inflammation; Ischemia reperfusion injury; Kidney transplantation; Proteoglycan

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; DOMINANT NEGATIVE CHEMOKINE CXCL8; GLYCOSAMINOGLYCAN; INTERLEUKIN 8; KI 67 ANTIGEN; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD FLOW; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; DISSOCIATION CONSTANT; DRUG BINDING; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; FISCHER 344 RAT; GLOMERULUS; GLOMERULUS FILTRATION; GRANULOCYTE; KIDNEY ALLOGRAFT REJECTION; KIDNEY INTERSTITIUM; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; KIDNEY TUBULE DAMAGE; LEWIS RAT; LYMPHOCYTIC INFILTRATION; MALE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; VASCULAR ENDOTHELIUM;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GLYCOSAMINOGLYCANS; GRAFT REJECTION; HUMANS; INTERLEUKIN-8; KIDNEY TRANSPLANTATION; MONOCYTES; NEUTROPHILS; RATS; RATS, INBRED F344; RATS, INBRED LEW; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; TRANSPLANTATION, HOMOLOGOUS;

RATTUS;

EID: 74449087903     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.11.012     Document Type: Article

References (41)

1. Bedke J., Kiss E., Behnes C.L., Popovic Z.V., Heuser M., Stojanovic T., Sijmonsma T., Huber P., Domhan S., Muschal S., Abdollahi A., Gretz N., and Grone H.J. Anti-inflammatory effects of alphav integrin antagonism in acute kidney allograft rejection. Am. J. Pathol. 171 (2007) 1127-1139
2. Bedke J., Kiss E., Schaefer L., Behnes C.L., Bonrouhi M., Gretz N., Horuk R., Diedrichs-Moehring M., Wildner G., Nelson P.J., and Grone H.J. Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am. J. Transplant 7 (2007) 527-537
3. Bertini R., Allegretti M., Bizzarri C., Moriconi A., Locati M., Zampella G., Cervellera M.N., Di Cioccio V., Cesta M.C., Galliera E., Martinez F.O., Di Bitondo R., Troiani G., Sabbatini V., D'Anniballe G., Anacardio R., Cutrin J.C., Cavalieri B., Mainiero F., Strippoli R., Villa P., Di Girolamo M., Martin F., Gentile M., Santoni A., Corda D., Poli G., Mantovani A., Ghezzi P., and Colotta F. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11791-11796
4. Charo I.F., and Ransohoff R.M. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354 (2006) 610-621
5. Cugini D., Azzollini N., Gagliardini E., Cassis P., Bertini R., Colotta F., Noris M., Remuzzi G., and Benigni A. Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion. Kidney Int. 67 (2005) 1753-1761
6. DeBruyne L.A., Li K., Bishop D.K., and Bromberg J.S. Gene transfer of virally encoded chemokine antagonists vMIP-II and MC148 prolongs cardiac allograft survival and inhibits donor-specific immunity. Gene Ther. 7 (2000) 575-582
7. El-Sawy T., Belperio J.A., Strieter R.M., Remick D.G., and Fairchild R.L. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112 (2005) 320-331
8. Engler R.L., Dahlgren M.D., Morris D.D., Peterson M.A., and Schmid-Schonbein G.W. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am. J. Physiol. 251 (1986) H314-H323
9. Falsone, S.F., Gesslbauer, B., Miller, I., Potzinger, H., Rek, A., Raikovic, E., Wabitsch, V., Krenn, E., Kungl, A.J., submitted for publication. Proteomic exploration of downstream signalling induced by CXCL8 binding to endothelial cells. Biochemica et Biophysica Acta.
10. Fischereder M., Luckow B., Hocher B., Wuthrich R.P., Rothenpieler U., Schneeberger H., Panzer U., Stahl R.A., Hauser I.A., Budde K., Neumayer H., Kramer B.K., Land W., and Schlondorff D. CC chemokine receptor 5 and renal-transplant survival. Lancet 357 (2001) 1758-1761
11. Frangogiannis N.G. Chemokines in the ischemic myocardium: from inflammation to fibrosis. Inflamm. Res. 53 (2004) 585-595
12. Furuichi K., Kaneko S., and Wada T. Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease. Clin. Exp. Nephrol. 13 (2009) 9-14
13. Gerszten R.E., Garcia-Zepeda E.A., Lim Y.C., Yoshida M., Ding H.A., Gimbrone Jr. M.A., Luster A.D., Luscinskas F.W., and Rosenzweig A. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398 (1999) 718-723
14. Grone H.J., and Helmchen U. Impairment and recovery of the clipped kidney in two kidney, one clip hypertensive rats during and after antihypertensive therapy. Lab. Invest. 54 (1986) 645-655
15. Grone H.J., Weber C., Weber K.S., Grone E.F., Rabelink T., Klier C.M., Wells T.N., Proudfood A.E., Schlondorff D., and Nelson P.J. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J. 13 (1999) 1371-1383
16. Holmes W.E., Lee J., Kuang W.J., Rice G.C., and Wood W.I. Structure and functional expression of a human interleukin-8 receptor. Science 253 (1991) 1278-1280
17. Kiss E., Adams J., Grone H.J., and Wagner J. Isotretinoin ameliorates renal damage in experimental acute renal allograft rejection. Transplantation 76 (2003) 480-489
18. Krieger E., Geretti E., Brandner B., Goger B., Wells T.N., and Kungl A.J. A structural and dynamic model for the interaction of interleukin-8 and glycosaminoglycans: support from isothermal fluorescence titrations. Proteins 54 (2004) 768-775
19. Kuschert G.S., Hoogewerf A.J., Proudfoot A.E., Chung C.W., Cooke R.M., Hubbard R.E., Wells T.N., and Sanderson P.N. Identification of a glycosaminoglycan binding surface on human interleukin-8. Biochemistry 37 (1998) 11193-11201
20. Lee S. An improved technique of renal transplantation in the rat. Surgery 61 (1967) 771
21. Luckow B., Joergensen J., Chilla S., Li J.P., Henger A., Kiss E., Wieczorek G., Roth L., Hartmann N., Hoffmann R., Kretzler M., Nelson P.J., Perez de Lema G., Maier H., Wurst W., Balling R., Pfeffer K., Grone H.J., Schlondorff D., and Zerwes H.G. Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur. J. Immunol. 34 (2004) 2568-2578
22. Middleton J., Neil S., Wintle J., Clark-Lewis I., Moore H., Lam C., Auer M., Hub E., and Rot A. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 91 (1997) 385-395
23. Mizutani A., Okajima K., Uchiba M., and Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95 (2000) 3781-3787
24. Murphy P.M., and Tiffany H.L. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 253 (1991) 1280-1283
25. Nankivell B.J., Borrows R.J., Fung C.L., O'Connell P.J., Allen R.D., and Chapman J.R. The natural history of chronic allograft nephropathy. N. Engl. J. Med. 349 (2003) 2326-2333
26. Nelson P.J. The production of chemokine specific monoclonal antibodies. Chemokine RANTES. Methods Mol. Biol. 138 (2000) 223-229
27. Nelson P.J., and Krensky A.M. Chemokines, chemokine receptors, and allograft rejection. Immunity 14 (2001) 377-386
28. Perico N., Cattaneo D., Sayegh M.H., and Remuzzi G. Delayed graft function in kidney transplantation. Lancet 364 (2004) 1814-1827
29. Proudfoot A.E., Handel T.M., Johnson Z., Lau E.K., LiWang P., Clark-Lewis I., Borlat F., Wells T.N., and Kosco-Vilbois M.H. Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 1885-1890
30. Rek, A., Potzinger, H., Wabitsch, V., Geretti, E., Piccinini, M.A., Falsone, S.F., Große Kracht, S., Teixeira, M., Adage, T., Kungl, A.J., submitted for publication. Turning the glycan switch to change CXCL8 into a potent anti-inflammatory biological drug. PNAS.
31. Robertson H., and Kirby J.A. Post-transplant renal tubulitis: the recruitment, differentiation and persistence of intra-epithelial T cells. Am. J. Transplant 3 (2003) 3-10
32. Segerer S., Djafarzadeh R., Grone H.J., Weingart C., Kerjaschki D., Weber C., Kungl A.J., Regele H., Proudfoot A.E., and Nelson P.J. Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation. J. Am. Soc. Nephrol. 18 (2007) 1835-1844
33. Segerer S., and Nelson P.J. Chemokines in renal diseases. ScientificWorldJournal 5 (2005) 835-844
34. Segerer S., and Schlondorff D. Role of chemokines for the localization of leukocyte subsets in the kidney. Semin. Nephrol. 27 (2007) 260-274
35. Sekido N., Mukaida N., Harada A., Nakanishi I., Watanabe Y., and Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 365 (1993) 654-657
36. Souza D.G., Bertini R., Vieira A.T., Cunha F.Q., Poole S., Allegretti M., Colotta F., and Teixeira M.M. Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br. J. Pharmacol. 143 (2004) 132-142
37. Stojanovic T., Bedke J., Grone H.J., Proudfoot A.E., Becker H., Markus P., and Hecker M. Met-RANTES inhibition of mucosal perfusion failure in acute intestinal transplant rejection-role of endothelial cell-leukocyte interaction. J. Vasc. Res. 39 (2002) 51-58
38. Takaishi K., Ohtsuka T., Tsuneyoshi S., Maehara N., Harada M., Yoshida H., Watanabe K., and Tsurufuji S. Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of IkappaBalpha. J. Biochem. 127 (2000) 511-516
39. Tarzami S.T., Miao W., Mani K., Lopez L., Factor S.M., Berman J.W., and Kitsis R.N. Opposing effects mediated by the chemokine receptor CXCR2 on myocardial ischemia-reperfusion injury: recruitment of potentially damaging neutrophils and direct myocardial protection. Circulation 108 (2003) 2387-2392
40. Thelen M., Peveri P., Kernen P., von Tscharner V., Walz A., and Baggiolini M. Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. FASEB J. 2 (1988) 2702-2706
41. Wu D., LaRosa G.J., and Simon M.I. G protein-coupled signal transduction pathways for interleukin-8. Science 261 (1993) 101-103