Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

Heart Rhythm

Volumn 12, Issue 1, 2015, Pages 181-192

  Gillet, Ludovic ^a   Rougier, Jean Sébastien ^a   Shy, Diana ^a   Sonntag, Stephan ^b   Mougenot, Nathalie ^c   Essers, Maria ^a   Shmerling, Doron ^b   Balse, Elise ^c,d,e   Hatem, Stéphane N ^c,d,e   Abriel, Hugues ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b POLYGENE AG   (Switzerland)

^c SORBONNE UNIVERSITÉ   (France)

^d INSERM   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Action potential; Potassium channel; SAP97; Sodium channel; Tissue specific knockout

Indexed keywords

ION CHANNEL; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MESSENGER RNA; POSTSYNAPTIC DENSITY PROTEIN 97; UNCLASSIFIED DRUG; DLGH1 PROTEIN, MOUSE; GUANYLATE KINASE; MEMBRANE PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL DURATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EXON; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QT PROLONGATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM CURRENT; WESTERN BLOTTING; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; ELECTROCARDIOGRAPHY; KNOCKOUT MOUSE; LONG QT SYNDROME; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; GUANYLATE KINASE; LONG QT SYNDROME; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; POTASSIUM CHANNELS, VOLTAGE-GATED; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84920688246     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.09.057     Document Type: Article

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