Schizophrenia as a disorder of molecular pathways

Biological Psychiatry

Volumn 77, Issue 1, 2015, Pages 22-28

  Horváth, Szatmár ^a,c   Mirnics, Károly ^a,b,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Convergence; Gene Expression; Gene Network; Genetics; Postmortem; Schizophrenia

Indexed keywords

MESSENGER RNA; TRANSCRIPTOME; UNTRANSLATED RNA;

CANNABIS ADDICTION; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; HUMAN; INTRAUTERINE INFECTION; LIFESTYLE; MALNUTRITION; MOLECULAR PATHOLOGY; NEWBORN HYPOXIA; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; SCHIZOPHRENIA; ANIMAL; GENOTYPE ENVIRONMENT INTERACTION; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84920662212     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.01.001     Document Type: Review

References (69)

1. S. Horvath, Z. Janka, and K. Mirnics Analyzing schizophrenia by DNA microarrays Biol Psychiatry 69 2011 157 162
2. M.T. Bhati Defining psychosis: The evolution of DSM-5 schizophrenia spectrum disorders Curr Psychiatry Rep 15 2013 409
3. M. Michel, M.J. Schmidt, and K. Mirnics Immune system gene dysregulation in autism and schizophrenia Dev Neurobiol 72 2012 1277 1287
4. R.A. Chambers, J.H. Krystal, and D.W. Self A neurobiological basis for substance abuse comorbidity in schizophrenia Biol Psychiatry 50 2001 71 83
5. K. Mirnics, P. Levitt, and D.A. Lewis Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry 60 2006 163 176
6. S. Horvath, and K. Mirnics Immune system disturbances in schizophrenia Biol Psychiatry 75 2013 316 323
7. G. Faludi, and K. Mirnics Synaptic changes in the brain of subjects with schizophrenia Int J Dev Neurosci 29 2011 305 309
8. K. Mirnics, F.A. Middleton, A. Marquez, D.A. Lewis, and P. Levitt Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex Neuron 28 2000 53 67
9. F.A. Middleton, K. Mirnics, J.N. Pierri, D.A. Lewis, and P. Levitt Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J Neurosci 22 2002 2718 2729
10. H.B. Clay, S. Sillivan, and C. Konradi Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia Int J Dev Neurosci 29 2010 311 324
11. D. Arion, T. Unger, D.A. Lewis, P. Levitt, and K. Mirnics Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia Biol Psychiatry 62 2007 711 721
12. T. Hashimoto, D. Arion, T. Unger, J.G. Maldonado-Aviles, H.M. Morris, and D.W. Volk Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia Mol Psychiatry 13 2008 147 161
13. D.A. Lewis, T. Hashimoto, and D.W. Volk Cortical inhibitory neurons and schizophrenia Nat Rev Neurosci 6 2005 312 324
14. P. Roussos, P. Katsel, K.L. Davis, L.J. Siever, and V. Haroutunian A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples Arch Gen Psychiatry 69 2012 1205 1213
15. Y. Hakak, J.R. Walker, C. Li, W.H. Wong, K.L. Davis, and J.D. Buxbaum Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia Proc Natl Acad Sci U S A 98 2001 4746 4751
16. D.P. Gavin, and S. Akbarian Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease Neurobiol Dis 46 2013 255 262
17. K. Mirnics, and D.A. Lewis Genes and subtypes of schizophrenia Trends Mol Med 7 2001 281 283
18. T.G. van Erp, I. Guella, M.P. Vawter, J. Turner, G.G. Brown, and G. McCarthy Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation [published online ahead of print August 1] Biol Psychiatry 2013 doi:10.1016/j.biopsych.2013.06.016
19. N.J. Beveridge, and M.J. Cairns MicroRNA dysregulation in schizophrenia Neurobiol Dis 46 2011 263 271
20. E.S. Gershon, N. Alliey-Rodriguez, and C. Liu After GWAS: Searching for genetic risk for schizophrenia and bipolar disorder Am J Psychiatry 168 2011 253 256
21. Cross-Disorder Group of the Psychiatric Genomics Consortium, Genetic Risk Outcome of Psychosis (GROUP) Consortium Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis Lancet 381 2013 1371 1379
22. S. Ripke, C. O'Dushlaine, K. Chambert, J.L. Moran, A.K. Kahler, and S. Akterin Genome-wide association analysis identifies 13 new risk loci for schizophrenia Nat Genet 45 2013 1150 1159
23. K.A. Aberg, Y. Liu, J. Bukszar, J.L. McClay, A.N. Khachane, and O.A. Andreassen A comprehensive family-based replication study of schizophrenia genes JAMA Psychiatry 70 2013 573 581
24. J. Duan, A.R. Sanders, and P.V. Gejman Genome-wide approaches to schizophrenia Brain Res Bull 83 2010 93 102
25. A.A. Curley, D. Arion, D.W. Volk, J.K. Asafu-Adjei, A.R. Sampson, K.N. Fish, and D.A. Lewis Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: Clinical, protein, and cell type-specific features Am J Psychiatry 168 2011 921 929
26. P. Saetre, L. Emilsson, E. Axelsson, J. Kreuger, E. Lindholm, and E. Jazin Inflammation-related genes up-regulated in schizophrenia brains BMC Psychiatry 7 2007 46
27. S.R. Gilman, J. Chang, B. Xu, T.S. Bawa, J.A. Gogos, M. Karayiorgou, and D. Vitkup Diverse types of genetic variation converge on functional gene networks involved in schizophrenia Nat Neurosci 15 2013 1723 1728
28. A.L. Richards, L. Jones, V. Moskvina, G. Kirov, P.V. Gejman, and D.F. Levinson Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain Mol Psychiatry 17 2012 193 201
29. A. Corvin, and D.W. Morris Genome-wide association studies: Findings at the major histocompatibility complex locus in psychosis [published online ahead of print September 29] Biol Psychiatry 2013
30. S. Kano, E. Nwulia, M. Niwa, Y. Chen, A. Sawa, and N. Cascella Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia Neurosci Res 71 2013 289 293
31. M.L. Sinkus, C.E. Adams, J. Logel, R. Freedman, and S. Leonard Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia Brain Behav Immun 32 2013 51 62
32. K.L. Bigos, V.S. Mattay, J.H. Callicott, R.E. Straub, R. Vakkalanka, and B. Kolachana Genetic variation in CACNA1C affects brain circuitries related to mental illness Arch Gen Psychiatry 67 2010 939 945
33. S. Kim, H. Cho, D. Lee, and M.J. Webster Association between SNPs and gene expression in multiple regions of the human brain Transl Psychiatry 2 2013 e113
34. A.S. Brown The environment and susceptibility to schizophrenia Prog Neurobiol 93 2010 23 58
35. T. Cash-Padgett, and H. Jaaro-Peled DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders Front Behav Neurosci 7 2013 113
36. M. Niwa, H. Jaaro-Peled, S. Tankou, S. Seshadri, T. Hikida, and Y. Matsumoto Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids Science 339 2013 335 339
37. D. Ibi, T. Nagai, A. Nakajima, H. Mizoguchi, T. Kawase, and D. Tsuboi Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice Glia 61 2013 679 693
38. X. Gonda, K.N. Fountoulakis, J. Harro, M. Pompili, H.S. Akiskal, G. Bagdy, and Z. Rihmer The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality J Psychopharmacol 25 2010 857 866
39. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, and H. Harrington Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389
40. O. Lazarov, J. Robinson, Y.P. Tang, I.S. Hairston, Z. Korade-Mirnics, and V.M. Lee Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice Cell 120 2005 701 713
41. Y. Fang Guiding research and practice: A conceptual model for aerobic exercise training in Alzheimer's disease Am J Alzheimers Dis Other Demen 26 2013 184 194
42. R. Grazina, and J. Massano Physical exercise and Parkinson's disease: Influence on symptoms, disease course and prevention Rev Neurosci 24 2013 139 152
43. A.D. Kloos, N.E. Fritz, S.K. Kostyk, G.S. Young, and D.A. Kegelmeyer Video game play (Dance Dance Revolution) as a potential exercise therapy in Huntington's disease: A controlled clinical trial Clin Rehabil 27 2013 972 982
44. Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium S. Ripke, N.R. Wray, C.M. Lewis, S.P. Hamilton, and M.M. Weissman A mega-analysis of genome-wide association studies for major depressive disorder Mol Psychiatry 18 2012 497 511
45. S. Horvath, and K. Mirnics Breaking the gene barrier in schizophrenia Nat Med 15 2009 488 490
46. D.A. Lewis, and P. Levitt Schizophrenia as a disorder of neurodevelopment Annu Rev Neurosci 25 2002 409 432
47. H.Y. Meltzer Update on typical and atypical antipsychotic drugs Annu Rev Med 64 2013 393 406
48. J.P. Zhang, and A.K. Malhotra Pharmacogenetics of antipsychotics: Recent progress and methodological issues Expert Opin Drug Metab Toxicol 9 2013 183 191
49. C. Glorioso, M. Sabatini, T. Unger, T. Hashimoto, L.M. Monteggia, D.A. Lewis, and K. Mirnics Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood Mol Psychiatry 11 2006 633 648
50. E.R. Chapman How does synaptotagmin trigger neurotransmitter release? Annu Rev Biochem 77 2008 615 641
51. F.A. Middleton, L. Peng, D.A. Lewis, P. Levitt, and K. Mirnics Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia Neuropsychopharmacology 30 2005 974 983
52. K. Mirnics What is in the brain soup? Nat Neurosci 11 2008 1237 1238
53. K.D. Winden, M.C. Oldham, K Mirnics, P.J. Ebert, C.H. Swan, and P. Levitt The organization of the transcriptional network in specific neuronal classes Mol Syst Biol 5 2009 291
54. W.B. Ruzicka, A. Zhubi, M. Veldic, D.R. Grayson, E. Costa, and A. Guidotti Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection Mol Psychiatry 12 2007 385 397
55. M.S. Sodhi, M. Simmons, R. McCullumsmith, V. Haroutunian, and J.H. Meador-Woodruff Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia Biol Psychiatry 70 2011 646 654
56. D. Arion, S. Horvath, D.A. Lewis, and K. Mirnics Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development? Neurobiol Dis 37 2009 738 746
57. D. Arion, T. Unger, D.A. Lewis, and K. Mirnics Molecular markers distinguishing supragranular and infragranular layers in the human prefrontal cortex Eur J Neurosci 25 2007 1843 1854
58. C. Faux, S. Rakic, W. Andrews, Y. Yanagawa, K. Obata, and J.G. Parnavelas Differential gene expression in migrating cortical interneurons during mouse forebrain development J Comp Neurol 518 2010 1232 1248
59. M. Nishioka, T. Shimada, M. Bundo, W. Ukai, E. Hashimoto, and T. Saito Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene Int J Dev Neurosci 31 2012 89 95
60. A.C. Mitchell, and K. Mirnics Gene expression profiling of the brain: Pondering facts and fiction Neurobiol Dis 45 2011 3 7
61. S.D. Ginsberg, and K. Mirnics Functional genomic methodologies Prog Brain Res 158 2006 15 40
62. G. Stober, D. Ben-Shachar, M. Cardon, P. Falkai, A.N. Fonteh, and M. Gawlik Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers World J Biol Psychiatry 10 2009 127 155
63. D.X. Yu, M.C. Marchetto, and F.H. Gage Therapeutic translation of iPSCs for treating neurological disease Cell Stem Cell 12 2013 678 688
64. S. Kano, C. Colantuoni, F. Han, Z. Zhou, Q. Yuan, and A. Wilson Genome-wide profiling of multiple histone methylations in olfactory cells: Further implications for cellular susceptibility to oxidative stress in schizophrenia Mol Psychiatry 18 2013 740 742
65. S. Gulsuner, T. Walsh, A.C. Watts, M.K. Lee, A.M. Thornton, and S. Casadei Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network Cell 154 2013 518 529
66. E.R. Kandel, H. Markram, P.M. Matthews, R. Yuste, and C. Koch Neuroscience thinks big (and collaboratively) Nat Rev Neurosci 14 2013 659 664
67. J.W. Lichtman, and J.R. Sanes Ome sweet ome: What can the genome tell us about the connectome? Curr Opin Neurobiol 18 2008 346 353
68. D.C. Van Essen, K. Ugurbil, E. Auerbach, D. Barch, T.E. Behrens, and R. Bucholz The Human Connectome Project: A data acquisition perspective Neuroimage 62 2012 2222 2231
69. L. Roberts, R.J. Davenport, E. Pennisi, and E. Marshall A history of the Human Genome Project Science 291 2001 1195