Serum copper and zinc levels in individuals with autism spectrum disorders

NeuroReport

Volumn 25, Issue 15, 2014, Pages 1216-1220

  Li, Si Ou ^a   Wang, Jia Liang ^a   Bjørklund, Geir ^b   Zhao, Wei Na ^a   Yin, Chang Hao ^a  

^a MUDANJIANG MEDICAL UNIVERSITY   (China)

^b Council for Nutritional and Environmental Medicine ^*  (Norway)

Author keywords

Autism spectrum disorders; Copper; Zinc; Zinc copper ratio

Indexed keywords

COPPER; ZINC; BIOLOGICAL MARKER;

ARTICLE; AUTISM; CHILD; CHILDHOOD AUTISM RATING SCALE; CHILDHOOD DISEASE; CHINESE; COMPARATIVE STUDY; CONTROLLED STUDY; COPPER BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE SEVERITY; FAMILY HISTORY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; ZINC BLOOD LEVEL; BLOOD; BLOOD ANALYSIS; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHINA; DIET RESTRICTION; HOSPITAL ADMISSION; PRESCHOOL CHILD; PSYCHOLOGICAL RATING SCALE;

BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; CHINA; COPPER; FASTING; FEMALE; HUMANS; MALE; PATIENT ADMISSION; PSYCHIATRIC STATUS RATING SCALES; ROC CURVE; SENSITIVITY AND SPECIFICITY; ZINC;

EID: 84920567434     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000251     Document Type: Article

References (26)

1. Sajdel-Sulkowska EM, Xu M, McGinnis W, Koibuchi N. Brain region-specific changes in oxidative stress and neurotrophin levels in autism spectrum disorders (ASD). Cerebellum 2011;10:43-48.
2. Faber S, Zinn GM, Kern JC 2nd, Kingston HM. The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers 2009;14:171-180.
3. Gong ZL, Luo CM, Wang L, Shen L, Wei F, Tong RJ, Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport 2014;25:23-27.
4. Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R. Genetics of autistic disorders: review and clinical implications. Eur Child Adolesc Psychiatry 2010;19:169-178.
5. Blaurock-Busch E, Amin OR, Dessoki HH, Rabah T. Toxic metals and essential elements in hair and severity of symptoms among children with autism. Maedica (Buchar) 2012;7:38-48.
6. Bjorklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp (Wars) 2013;73:225-236.
7. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68(Suppl):447S-463S.
8. Fischer Walker C, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr 2004;24:255-275.
9. Leary SC, Winge DR, Cobine PA. 'Pulling the plug' on cellular copper: the role of mitochondria in copper export. Biochim Biophys Acta 2009;1793:146-153.
10. Roelofsen H, Balgobind R, Vonk RJ. Proteomic analyzes of copper metabolism in an in vitro model of Wilson disease using surface enhanced laser desorption/ionization-time of flight-mass spectrometry. J Cell Biochem 2004;93:732-740.
11. Stelmashook EV, Isaev NK, Genrikhs EE, Amelkina GA, Khaspekov LG, Skrebitsky VG, Illarioshkin SN. Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer's and Parkinson's diseases. Biochemistry (Mosc) 2014;79:391-396.
12. Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, et al. Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis. J Biol Chem 2013;288:15699-15711.
13. Masánová V, Mitrova E, Ursinyova M, Uhnakova I, Slivarichova D. Manganese and copper imbalance in the food chain constituents in relation to Creutzfeldt-Jakob disease. Int J Environ Health Res 2007;17:419-428.
14. Vidović B, Dorʇević B, Milovanović S, Škrivanj S, Pavlović Z, Stefanović A, Kotur-Stevuljević J. Selenium, zinc, and copper plasma levels in patients with schizophrenia: relationship with metabolic risk factors. Biol Trace Elem Res 2013;156:22-28.
15. Schopler E, Reichler RJ, De Vellis RF, Daly K. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord 1980;10:91-103.
16. Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Toxicological status of children with autism vs. neurotypical children and the association with autism severity. Biol Trace Elem Res 2013;151:171-180.
17. Russo AJ, Bazin AP, Bigega R, Carlson RS 3rd, Cole MG, Contreras DC, et al. Plasma copper and zinc concentration in individuals with autism correlate with selected symptom severity. Nutr Metab Insights 2012;5:41-47.
18. Walsh WJ, Usman A, Tarpey J. Disordered metal metabolism in a large autism population. Presented at the American Psychiatric Association Annual Meeting. May, 2001, New Orleans. Available at: http://www.safeminds.org/research/library/20010501.pdf.
19. Russo AJ, Devito R. Analysis of copper and zinc plasma concentration and the efficacy of zinc therapy in individuals with Asperger's syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism. Biomark Insights 2011;6:127-133.
20. Rosenzweig AC. Copper delivery by metallochaperone proteins. Acc Chem Res 2001;34:119-128.
21. Ozdemir E, Cetinkaya S, Ersan S, Kucukosman S, Ersan EE. Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:62-65.
22. De Bie P, Van De Sluis B, Klomp L, Wijmenga C. The many faces of the copper metabolism protein MURR1/COMMD1. J Hered 2005;96:803-811.
23. Herbein G, Varin A, Fulop T. NF-kappaB, AP-1, zinc-deficiency and aging. Biogerontology 2006;7:409-419.
24. Gower-Winter SD, Levenson CW. Zinc in the central nervous system: From molecules to behavior. Biofactors 2012;38:186-193.
25. Takeda A, Itoh H, Imano S, Oku N. Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation. Neurochem Int 2006;49:746-750.
26. Kim H, Macdonald RL. An N-terminal histidine is the primary determinant of alpha subunit-dependent Cu2+ sensitivity of alphabeta3gamma2L GABA (A) receptors. Mol Pharmacol 2003;64:1145-1152.