Curcumin and quercetin trigger apoptosis during benzo(a)pyrene-induced lung carcinogenesis

Molecular and Cellular Biochemistry

Volumn 400, Issue 1-2, 2015, Pages 51-56

  Nair, Praveen ^a   Malhotra, Anshoo ^b   Dhawan, Devinder K ^c  

^a NSSC   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Apoptosis; Curcumin; Lung carcinogenesis; Quercetin

Indexed keywords

BENZO[A]PYRENE; CASPASE 3; CASPASE 9; CURCUMIN; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN; BAX PROTEIN, HUMAN; BCR PROTEIN, HUMAN; BREAKPOINT CLUSTER REGION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOBLOTTING; LUNG CARCINOGENESIS; LUNG HOMOGENATE; MALE; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CARCINOGENESIS; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG NEOPLASMS;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZO(A)PYRENE; CARCINOGENESIS; CASPASE 3; CASPASE 9; CURCUMIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-BCR; QUERCETIN;

EID: 84920564406     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2261-6     Document Type: Article

References (30)

1. Alberg AJ, Ford JG, Samet JM (2007) Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132:29S–55S
2. Eisen T, Matakidou A, Houlston R (2008) Identification of low penetrance alleles for lung cancer: the GEnetic Lung CAncer Predisposition Study. BMC Cancer. doi:10.1186/1471-2407-8-244
3. Han SW, Roman J (2010) Targeting apoptotic signaling pathways in human lung cancer. Curr Cancer Drug Targets 10:566–574
4. Hara A, Hirose Y, Wang A, Yoshimi N, Tanaka T, Mori H (1996) Localization of Bar and bcl-2 proteins, regulators of programmed cell death, in the human central nervous system. Virchows Arch 429:249–253
5. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440–442
6. Cullen SP, Martin SJ (2009) Caspase activation pathways: some recent progress. Cell Death Differ 16:935–938
7. Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495–516
8. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H et al (1998) Reduced apoptosis and cytochrome C-mediated caspase activation in mice lacking caspase 9. Cell 94:325–337
9. Li H, Chen Y, Chen G, Xie B, Lin L (2008) Expression of livin protein in lung cancer and its relation with the expression of pro-caspase3 protein. Chin J Lung Cancer 11:729–733
10. Park JY, Park JM, Jang JS, Choi JE, Kim KM, Cha SI et al (2006) Caspase 9 promoter polymorphisms and risk of primary lung cancer. Hum Mol Genet 15:1963–1971
11. Kawamori TLR, Steele VE, Kelloff GJ, Kaskey RB, Rao CV, Reddy BS (1999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 59:597–601
12. López-Lázaro M (2008) Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res 52:S103–S127
13. Elattar TMA, Virji AS (1999) The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res 19:5407–5414
14. Richter M, Ebermann R, Marian B (1999) Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer 34:88–99
15. Gunning WT, Kramer PM, Lubet RA, Steele VE, End DW, Wouters W, Pereira MA (2003) Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777. Clin Cancer Res 9:1927–1930
16. Malhotra A, Nair P, Dhawan DK (2011) Curcumin and resveratrol synergistically stimulate p21 and regulate cox 2 by maintaining adequate zinc levels during lung carcinogenesis. Eur J Cancer Prev 20(5):411–416
17. Saxena L, Kumar GR, Saxena S, Chaturvedi U, Sahoo AP, Singh LV et al (2013) Apoptosis induced by NS1 gene of canine parvovirus-2 is caspase dependent and p53 independent. Virus Res 173:426–430
18. Chiu TL, Su CC (2009) Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells. Int J Mol Med 23:469–475
19. Granado-Serrano AB, Martín MA, Bravo L, Goya L, Ramos S (2006) Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136:2715–2721
20. Porter AG, Jänicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99–104
21. Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH, Tora AD, Mehta K (2002) Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 21:8843–8851
22. Garg R, Maru G (2009) Dietary curcumin enhances benzo(a)pyrene-induced apoptosis resulting in a decrease in BPDE-DNA adducts in mice. J Environ Pathol Toxicol Oncol 28:121–131
23. Kang SK, Cha SH, Jeon HG (2006) Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells. Stem Cells Dev 15:165–174
24. 2+ and the activation of caspase-3. Anticancer Res 26:4379–4389
25. Chien SY, Wu YC, Chung JG, Yang JS, Lu HF, Tsou MF et al (2009) Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol 28:493–503
26. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS et al (1998) Differential requirement for Caspase 9 in apoptotic pathways in vivo. Cell 94:339–352
27. An J, Chen Y, Huang Z (2004) Critical upstream signals of cytochrome c release induced by a novel Bcl-2 inhibitor. J Biol Chem 279:19133–19140
28. Tian DDS, Doshi JM, Peng J, Lin J, Xing C (2008) sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. Cancer Lett 259:198–208
29. Kuida K (2000) Caspase-9. Int J Biochem Cell Biol 32:121–124
30. Sen S, Sharma H, Singh N (2005) Curcumin enhances vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem Biophys Res Commun 331:1245–1252