Endothelium-derived relaxing factors of small resistance arteries in hypertension

Toxicological Research

Volumn 30, Issue 3, 2014, Pages 141-148

  Kang, Kyu Tae ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Endothelium derived relaxing factors; Hypertension; Small resistance arteries

Indexed keywords

ANIMALIA; MUS;

EID: 84920549074     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2014.30.3.141     Document Type: Article

References (77)

1. Furchgott, R.F. and Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
2. Vanhoutte, P.M. (1989) Endothelium and control of vascular function. State of the Art lecture. Hypertension, 13, 658-667.
3. Luscher, T.F. and Barton, M. (1997) Biology of the endothelium. Clin. Cardiol., 20, II-3-10.
4. Palmer, R.M., Ferrige, A.G. and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524-526.
5. Dudzinski, D.M., Igarashi, J., Greif, D. and Michel, T. (2006) The regulation and pharmacology of endothelial nitric oxide synthase. Annu. Rev. Pharmacol. Toxicol., 46, 235-276.
6. Oelze, M., Mollnau, H., Hoffmann, N., Warnholtz, A., Bodenschatz, M., Smolenski, A., Walter, U., Skatchkov, M., Meinertz, T. and Munzel, T. (2000) Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ. Res., 87, 999-1005.
7. Halbrugge, M., Friedrich, C., Eigenthaler, M., Schanzenbächer, P. and Walter, U. (1990) Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators. J. Biol. Chem., 265, 3088-3093.
8. Reinhard, M., Halbrügge, M., Scheer, U., Wiegand, C., Jockusch, B.M. and Walter, U. (1992) The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J., 11, 2063-2070.
9. Smolenski, A., Bachmann, C., Reinhard, K., Hönig-Liedl, P., Jarchau, T., Hoschuetzky, H. and Walter, U. (1998) Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody. J. Biol. Chem., 273, 20029-20035.
10. Chen, L., Daum, G., Chitaley, K., Coats, S.A., Bowen-Pope, D.F., Eigenthaler, M., Thumati, N.R., Walter, U. and Clowes, A.W. (2004) Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 24, 1403-1408.
11. Aszódi, A., Pfeifer, A., Ahmad, M., Glauner, M., Zhou, X.H., Ny, L., Andersson, K.E., Kehrel, B., Offermanns, S. and Fassler, R. (1999) The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J., 18, 37-48.
12. Fleming, I. and Busse, R. (2003) Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1-12.
13. Kukovetz, W.R., Holzmann, S., Wurm, A. and Pöch, G. (1979) Prostacyclin increases cAMP in coronary arteries. J. Cyclic Nucleotide Res., 5, 469-476.
14. Chang, J., Musser, J.H. and McGregor, H. (1987) Phospholipase A2: function and pharmacological regulation. Biochem. Pharmacol., 36, 2429-2436.
15. Imig, J.D., Zou, A.P., Stec, D.E., Harder, D.R., Falck, J.R. and Roman, R.J. (1996) Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am. J. Physiol., 270, R217-227.
16. Bunting, S., Moncada, S. and Vane, J.R. (1983) The prostacyclin--thromboxane A2 balance: pathophysiological and therapeutic implications. Br. Med. Bull., 39, 271-276.
17. Vanhoutte, P.M. (1987) Vascular physiology: the end of the quest? Nature, 327, 459-460.
18. Chen, G., Suzuki, H. and Weston, A.H. (1988) Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol., 95, 1165-1174.
19. Félétou, M. and Vanhoutte, P.M. (2006) Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler. Thromb. Vasc. Biol., 26, 1215-1225.
20. Tomioka, H., Hattori, Y., Fukao, M., Sato, A., Liu, M., Sakuma, I., Kitabatake, A. and Kanno, M. (1999) Relaxation in different-sized rat blood vessels mediated by endotheliumderived hyperpolarizing factor: importance of processes mediating precontractions. J. Vasc. Res., 36, 311-320.
21. Huang, A., Sun, D., Smith, C.J., Connetta, J.A., Shesely, E.G., Koller, A. and Kaley, G. (2000) In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am. J. Physiol. Heart Circ. Physiol., 278, H762-768.
22. Jackson, W.F. (2000) Ion channels and vascular tone. Hypertension, 35, 173-178.
23. Vanhoutte, P.M. (2004) Endothelium-dependent hyperpolarizations: the history. Pharmacol. Res., 49, 503-508.
24. Edwards, G., Dora, K.A., Gardener, M.J., Garland, C.J. and Weston, A.H. (1998) K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Nature, 396, 269-272.
25. Taylor, H.J., Chaytor, A.T., Evans, W.H. and Griffith, T.M. (1998) Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-alpha glycyrrhetinic acid. Br. J. Pharmacol., 125, 1-3.
26. Edwards, G., Félétou, M., Gardener, M.J., Thollon, C., Vanhoutte, P.M. and Weston, A.H. (1999) Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br. J. Pharmacol., 128, 1788-1794.
27. Mather, S., Dora, K.A., Sandow, S.L., Winter, P. and Garland, C.J. (2005) Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries. Circ. Res., 97, 399-407.
28. Kansui, Y., Fujii, K., Nakamura, K., Goto, K., Oniki, H., Abe, I., Shibata, Y. and Iida, M. (2004) Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats. Am. J. Physiol. Heart Circ. Physiol., 287, H216-224.
29. Campbell, W.B. and Harder, D.R. (1999) Endotheliumderived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ. Res., 84, 484-488.
30. Fisslthaler, B., Popp, R., Kiss, L., Potente, M., Harder, D.R., Fleming, I. and Busse, R. (1999) Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature, 401, 493-497.
31. Nithipatikom, K., Pratt, P.F. and Campbell, W.B. (2000) Determination of EETs using microbore liquid chromatography with fluorescence detection. Am. J. Physiol. Heart Circ. Physiol., 279, H857-862.
32. Campbell, W.B., Falck, J.R. and Gauthier, K. (2001) Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries. Med. Sci. Monit., 7, 578-584.
33. Pratt, P.F., Li, P., Hillard, C.J., Kurian, J. and Campbell, W.B. (2001) Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. Am. J. Physiol. Heart Circ. Physiol., 280, H1113-1121.
34. Li, P.L. and Campbell, W.B. (1997) Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ. Res., 80, 877-884.
35. Imig, J.D., Inscho, E.W., Deichmann, P.C., Reddy, K.M. and Falck, J.R. (1999) Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A. Hypertension, 33, 408-413.
36. Earley, S., Heppner, T.J., Nelson, M.T. and Brayden, J.E. (2005) TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ. Res., 97, 1270-1279.
37. Coats, P., Johnston, F., MacDonald, J., McMurray, J.J. and Hillier, C. (2001) Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries. Circulation, 103, 1702-1708.
38. Ardanaz, N. and Pagano, P.J. (2006) Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction. Exp. Biol. Med. (Maywood), 231, 237-251.
39. Shimokawa, H. and Morikawa, K. (2005) Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans. J. Mol. Cell. Cardiol., 39, 725-732.
40. Gao, Y.J., Hirota, S., Zhang, D.W., Janssen, L.J. and Lee, R.M. (2003) Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery. Br. J. Pharmacol., 138, 1085-1092.
41. Matoba, T., Shimokawa, H., Nakashima, M., Hirakawa, Y., Mukai, Y., Hirano, K., Kanaide, H. and Takeshita, A. (2000) Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J. Clin. Invest., 106, 1521-1530.
42. Katusic, Z.S. (1996) Superoxide anion and endothelial regulation of arterial tone. Free Radical Biol. Med., 20, 443-448.
43. Sullivan, J.C., Pollock, D.M. and Pollock, J.S. (2002) Altered nitric oxide synthase 3 distribution in mesenteric arteries of hypertensive rats. Hypertension, 39, 597-602.
44. Nava, E., Llinás, M.T., Gonzalez, J.D. and Salazar, F.J. (1996) Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hypertensive rats. Am. J. Hypertens., 9, 1236-1239.
45. Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M., Thaiss, F., Stahl, R.A., Warnholtz, A., Meinertz, T., Griendling, K., Harrison, D.G., Forstermann, U. and Munzel, T. (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ. Res., 88, E14-22.
46. Laursen, J.B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B.A., Tarpey, M., Fukai, T. and Harrison, D.G. (2001) Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation, 103, 1282-1288.
47. Forstermann, U. and Munzel, T. (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation, 113, 1708-1714.
48. Gallego, M.J., Lopez Farre, A., Riesco, A., Monton, M., Grandes, S.M., Barat, A., Hernando, L., Casado, S. and Caramelo, C.A. (1993) Blockade of endothelium-dependent responses in conscious rats by cyclosporin A: effect of L-arginine. Am. J. Physiol., 264, H708-714.
49. Lee, M.Y., Jung, B.I., Chung, S.M., Bae, O.N., Lee, J.Y., Park, J.D., Yang, J.S., Lee, H. and Chung, J.H. (2003) Arsenicinduced dysfunction in relaxation of blood vessels. Environ. Health Perspect., 111, 513-517.
50. Lüscher, T.F. (1994) The endothelium in hypertension: bystander, target or mediator? J. Hypertens. Suppl., 12, S105-116.
51. Taddei, S., Virdis, A., Mattei, P. and Salvetti, A. (1993) Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension, 21, 929-933.
52. Linder, L., Kiowski, W., Buhler, F.R. and Luscher, T.F. (1990) Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation, 81, 1762-1767.
53. Treasure, C.B., Klein, J.L., Vita, J.A., Manoukian, S.V., Renwick, G.H., Selwyn, A.P., Ganz, P. and Alexander, R.W. (1993) Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels. Circulation, 87, 86-93.
54. Hongo, K., Nakagomi, T., Kassell, N.F., Sasaki, T., Lehman, M., Vollmer, D.G., Tsukahara, T., Ogawa, H. and Torner, J. (1988) Effects of aging and hypertension on endotheliumdependent vascular relaxation in rat carotid artery. Stroke, 19, 892-897.
55. Dohi, Y., Thiel, M.A., Buhler, F.R. and Luscher, T.F. (1990) Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension. Hypertension, 16, 170-179.
56. Lüscher, T.F., Vanhoutte, P.M. and Raij, L. (1987) Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension. Hypertension, 9, III193-197.
57. Takase, H., Moreau, P., Küng, C.F., Nava, E. and Luscher, T.F. (1996) Antihypertensive therapy prevents endothelial dysfunction in chronic nitric oxide deficiency. Effect of verapamil and trandolapril. Hypertension, 27, 25-31.
58. Luscher, T.F., Dohi, Y. and Tschudi, M. (1992) Endotheliumdependent regulation of resistance arteries: alterations with aging and hypertension. J. Cardiovasc. Pharmacol., 19 Suppl 5, S34-42.
59. Taddei, S., Virdis, A., Mattei, P., Arzilli, F. and Salvetti, A. (1992) Endothelium-dependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension. J. Cardiovasc. Pharmacol., 20 Suppl 12, S193-195.
60. Sim, M.K. and Singh, M. (1987) Decreased responsiveness of the aortae of hypertensive rats to acetylcholine, histamine and noradrenaline. Br. J. Pharmacol., 90, 147-150.
61. Somers, M.J., Mavromatis, K., Galis, Z.S. and Harrison, D.G. (2000) Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetatesalt. Circulation, 101, 1722-1728.
62. Bennett, M.A., Watt, P.A. and Thurston, H. (1993) Impaired endothelium-dependent relaxation in two-kidney, one clip Goldblatt hypertension: effect of vasoconstrictor prostanoids. J. Hypertens. Suppl., 11, S134-135.
63. Laursen, J.B., Rajagopalan, S., Galis, Z., Tarpey, M., Freeman, B.A. and Harrison, D.G. (1997) Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation, 95, 588-593.
64. White, R.M., Rivera, C.O. and Davison, C.B. (1996) Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosteronesalt hypertensive rats. Hypertension, 27, 1245-1253.
65. Pu, Q., Touyz, R.M. and Schiffrin, E.L. (2002) Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. J. Hypertens., 20, 899-907.
66. Li, J. and Bukoski, R.D. (1993) Endothelium-dependent relaxation of hypertensive resistance arteries is not impaired under all conditions. Circ. Res., 72, 290-296.
67. Fujii, K., Tominaga, M., Ohmori, S., Kobayashi, K., Koga, T., Takata, Y. and Fujishima, M. (1992) Decreased endotheliumdependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats. Circ. Res., 70, 660-669.
68. Virdis, A., Neves, M.F., Amiri, F., Viel, E., Touyz, R.M. and Schiffrin, E.L. (2002) Spironolactone improves angiotensininduced vascular changes and oxidative stress. Hypertension, 40, 504-510.
69. Wang, D., Chabrashvili, T., Borrego, L., Aslam, S. and Umans, J.G. (2006) Angiotensin II infusion alters vascular function in mouse resistance vessels: roles of O and endothelium. J. Vasc. Res., 43, 109-119.
70. Deng, L.Y., Li, J.S. and Schiffrin, E.L. (1995) Endotheliumdependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats. Clin. Sci. (Lond), 88, 611-622.
71. Rizzoni, D., Porteri, E., Castellano, M., Bettoni, G., Muiesan, M.L., Muiesan, P., Giulini, S.M. and Agabiti-Rosei, E. (1996) Vascular hypertrophy and remodeling in secondary hypertension. Hypertension, 28, 785-790.
72. Cockcroft, J.R., Chowienczyk, P.J., Benjamin, N. and Ritter, J.M. (1994) Preserved endothelium-dependent vasodilatation in patients with essential hypertension. N. Engl. J. Med., 330, 1036-1040.
73. Bruning, T.A., Chang, P.C., Hendriks, M.G., Vermeij, P., Pfaffendorf, M. and van Zwieten, P.A. (1995) In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension. Hypertension, 26, 70-77.
74. Thybo, N.K., Mulvany, M.J., Jastrup, B., Nielsen, H. and Aalkjaer, C. (1996) Some pharmacological and elastic characteristics of isolated subcutaneous small arteries from patients with essential hypertension. J. Hypertens., 14, 993-998.
75. Furchgott, R.F. and Vanhoutte, P.M. (1989) Endotheliumderived relaxing and contracting factors. FASEB J., 3, 2007-2018.
76. Garland, C.J., Plane, F., Kemp, B.K. and Cocks, T.M. (1995) Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol. Sci., 16, 23-30.
77. Kang, K.T., Sullivan, J.C., Sasser, J.M., Imig, J.D. and Pollock, J.S. (2007) Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats. Hypertension, 49, 893-901.