Afferent arteriolar vasodilation to the sulfonimide analog of 11,12- epoxyeicosatrienoic acid involves protein kinase A

Hypertension

Volumn 33, Issue 1 II, 1999, Pages 408-413

  Imig, John D ^a   Inscho, Edward W ^a   Deichmann, Paul C ^a   Reddy, K Malla ^b   Falck, John R ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arterioles; Cyclic adenosine monophosphate; Cyclic guanosine monophosphate; Endothelium derived hyperpolarizing factor; Kidney; Metabolites, cytochrome P450

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HEPOXILIN B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARACHIDONIC ACID METABOLISM; ARTERIOLE; ARTERY DIAMETER; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; KIDNEY BLOOD FLOW; KIDNEY TUBULE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0032942665     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.33.1.408     Document Type: Article

References (40)

1. Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. Am J Physiol. 1990;258:F781-F789.
2. Carroll MA, Garcia MP, Falck JR, McGiff JC. Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. J Pharmacol Exp Ther. 1992;260:104-109.
3. Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in the rat kidney. Am J Physiol 1991; 261:F578-F586.
4. Imig JD, Navar LG, Roman RJ, Reddy KK, Falck JR. Actions of epoxygenase metabolites on the preglomerular vasculature. J Am Soc Nephrol. 1996;7:2364-2370.
5. Sakairi Y, Jacobson HR, Noland TD, Capdevila JH, Falck JR, Breyer MD. 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. Am J Physiol. 1995;268:F931-F939.
6. Madhun ZT, Goldthwait DA, McKay D, Hopfer U, Douglas JG. An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells. J Clin Invest. 1991;88:456-461.
7. Capdevila J, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, Dubois RN. Cytochrome P-450 arachidonic acid epoxygenase: regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem. 1992;267:21720-21726.
8. Makita K, Takahashi K, Karara A, Jacobson HR, Falck JR, Capdevila JH. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Invest. 1994;94:2414-2420.
9. Sacerdoti D, Abraham NG, McGiff JC, Schwartzman ML. Renal cytochrome P450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats. Biochem Pharmacol. 1988;37:521-527.
10. Gebremedhin D, Ma YH, Imig JD, Harder DR, Roman RJ. Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. J Vasc Res. 1993;30:53-60.
11. Fulton D, McGiff JC, Quilley J. Contribution of nitric oxide and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney. Br J Pharmacol. 1992;107:722-725.
12. Hecker M, Bara AT, Bauersachs J, Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome p450-derived arachidonic acid metabolite in mammals. J Physiol. 1994;481:407-414.
13. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 1996;78:415-423.
14. + channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid. Eur J Pharmacol. 1993;230:215-221.
15. +-channel activity. Am J Physiol. 1996;270: F822-F832.
16. Nelson MT, Quayle JM. Physiological role and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995;268:C799-C822.
17. Schaaf TK, Hess H-J. Synthesis and biological activity of carboxylterminus modified prostaglandin analogues. J Med Chem. 1979;22: 1340-1346.
18. Imig JD, Navar LG. Afferent arteriolar response to arachidonic acid: involvement of metabolic pathways. Am J Physiol. 1996;271:F87-F93.
19. Falck JR, Yadagiri P, Capdevila J. Synthesis of Epoxyeicosatrienoic Acids and Heteroatom Analogs. In Methods in Enzymology 187: Arachidonate Related Lipid Mediators. Edited by R.C. Murphy and F.A. Fitzpatrick. Academic Press, Inc., San Diego, 1990, pp. 357-364.
20. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H. Inhibition of forskolin-induced neunte out-growth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 1990;265:5267-5272.
21. Glass DB, Cheng HC, Mende-Mueller L, Reed J, Walsh DA. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem. 1989;264:8802-8810.
22. Glass DB. Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem J. 1983;213:159-164.
23. Alonso-Galicia M, Sun CW, Falck JR, Harder DR, Roman RJ. Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. Am J Physiol. 1998;44:F370-F378.
24. Dellipizzi A, Pucci ML, Mosny AY, Deseyn K, Nasjletti A. Contribution of constrictor prostanoids to the calcium-dependent basal tone in the aorta from rats with aortic coarctation-induced hypertension: relationship to nitric oxide. J Pharmacol Exp Ther. 1997;283:75-81.
25. Chen J-K, Falck JR, Reddy KM, Capdevila J, Harris RC. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem. 1998;273:29254-29261.
26. Wang M-H, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther. 1998;284:966-973.
27. Harder DR, Campbell WB, Roman RJ. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res. 1995;32:79-92.
28. Karara A, Makita K, Jacobson HR, Falck JR, Guengerich FP, DuBois RN, Capdevila JH. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem. 1993;268:13565-13570.
29. Karara A, Dishman E, Jacobson H, Falck JR, Capdevila J. Stereochemical analysis of endogenous epoxyeicosatrienoic acids of human kidney cortex. J Biol Chem. 1993;268:24543-24546.
30. Zou AP, Imig JD, Kaldunski ML, Ortiz de Montellano PR, Sui Z, Roman RJ. Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am J Physiol. 1994;266:F275-F282.
31. Imig JD, Gebremedhin D, Zou AP, Stec DE, Harder DR, Falck JR, Roman RJ. Formation and actions of 20-hydroxyeicosatetraenoic acid in the renal microcirculation. Am J Physiol. 1996;270:R217-R227.
32. Chataigneau T, Feletou M, Duhault J, Vanhoutte PM. Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. Br J Pharmacol. 1998; 123:574-580.
33. Gebremedhin D, Ma YH, Roman RJ, VanRollins M, Harder DR. Cellular mechanisms of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol. 1992;263:H519-H525.
34. Leffler CW, Fedinec AL. Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. Am J Physiol. 1997;273: H333-H338.
35. Li PL, Zou AP, Campbell WB. Regulation of potassium channels in coronary arterial smooth muscle by endothelium-derived vasodilators. Hypertension. 1997;29:262-267.
36. + channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ Res. 1997;80:877-884.
37. 2+ channels and contraction in mammalian heart cells. J Physiol. 1998;508:777-792.
38. Lincoln TM, Cornwell TL. Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels. 1991;28:129-137.
39. Oyekan AO, McGiff JC, Quilley J. Cytochrome P-450-dependent vasodilator responses to arachidonic acid in the isolated, perfused kidney of the rat. Circ Res. 1991;68:958-965.
40. Bauersachs J, Fleming I, Scholz D, Popp R, Busse R. Endothelium-derived hyperpolarizing factor, but not nitric oxide, is reversibly inhibited by brefeldin A. Hypertension. 1997;30:1598-1605.