Some pharmacological and elastic characteristics of isolated subcutaneous small arteries from patients with essential hypertension

Journal of Hypertension

Volumn 14, Issue 8, 1996, Pages 993-998

  Thybo, Niels K ^a   Mulvany, Michael J ^a   Jastrup, Birthe ^b   Nielsen, Henrik ^a   Aalkjær, Christian ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Department of Medicine   (Denmark)

Author keywords

Acetylcholine; Calcium; Endothelium; Felodipine; Hypertension; Nitroprusside; Small arteries; Young's modulus

Indexed keywords

ACETYLCHOLINE; CAFFEINE; FELODIPINE; NITROPRUSSIDE SODIUM; NORADRENALIN; PRAZOSIN; YOHIMBINE;

ADULT; ARTERY WALL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELASTICITY; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN TISSUE; ISOLATED ARTERY; MALE; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; YOUNG MODULUS;

EID: 0029815397     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199608000-00009     Document Type: Article

References (33)

1. Short D: Morphology of the intestinal arterioles in chronic human hypertension. Br Heart J 1966, 28:184-192.
2. Sivertsson R: The hemodynamic importance of structural vascular changes in essential hypertension. Acta Physiol Scand Suppl 1970, 343:1-56.
3. Folkow B: Physiological aspects of primary hypertension. Physiol Rev 1982, 62:347-504.
4. Aalkjaer C, Heagerty AM, Petersen KK, Swales JD, Mulvany MJ: Evidence for increased media thickness, increased neuronal amine uptake and depressed excitation contraction coupling in isolated resistance vessels from essential hypertensives. Circ Res 1987, 61:181-186.
5. Egan B, Schork N, Panis R, Hinderliter A: Vascular structure enhances regional resistance response in mild hypertension. J Hypertens 1988, 6:41-48.
6. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ: Small artery structure in essential hypertension: dual processes of remodelling and growth. Hypertension 1993, 21:391-397.
7. Mulvany MJ: Biophysical aspects of resistance vessels studied in spontaneous and renal hypertensive rats. Acta Physiol Scand Suppl 1988, 571:129-138.
8. Baumbach GL, Dobrin PB, Hart MN, Heistad DD: Mechanics of cerebral arterioles in hypertensive rats. Circ Res 1988, 62:56-64.
9. Laurent S: Arterial wall hypertrophy and stiffness in essential hypertensive patients. Hypertension 1995, 26:355-362.
10. Pearson AC, Guo R, Orsinelli DA, Binkley PF, Pasierski TJ: Transesophageal echocardiographic assessment of the effects of age, gender and hypertension on thoracic aortic wall size, thickness, and stiffness. Am Heart J 1994, 128:344-351.
11. Lauren S, Girerd X, Mourad JJ, Lacolley P, Beck L, Boutouyrie P, et al.: Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension. Arterioscler Thromb 1994, 14:1223-1231.
12. Robinson BF, Dobbs RJ, Bayley S: Responses of forearm resistance vessels to verapamil and sodium nitroprusside in normotensive and hypertensive men: evidence for a functional abnormality of vascular smooth muscle in primary hypertension. Clin Sci Lond 1982, 63:33-42.
13. Linder L, Kiowski W, Bühler FR, Lüscher TF: Indirect evidence for the release of endothelium-derived relaxing factor in the human forearm circulation in vivo. Circulation 1990, 81:1762-1767.
14. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE: Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990, 323:22-27.
15. Taddei S, Virdis A, Mattei P, Salvetti A: Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993, 21:929-933.
16. Schiffrin EL, Deng LY, Larochelle P: Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients. J Hypertens 1992, 10:437-444.
17. Mulvany MJ, Halpern W: Mechanical properties of vascular smooth muscle cells in situ. Nature 1976, 260:617-619.
18. Mulvany MJ, Warshaw DM: The active tensionlength curve of vascular smooth muscle related to its cellular components. J Gen Physiol 1979, 74:84-104.
19. Mulvany MJ, Korsgaard N: Correlations and otherwise between blood pressure, cardiac mass and resistance vessel characteristics in hypertensive, normotensive and hypertensive/normotensive hybrid rats. J Hypertens 1983, 1:235-244.
20. Baumbach GL, Heistad DD: Remodelling of cerebral arterioles in chronic hypertension. Hypertension 1989, 13:968-972.
21. Falloon BJ, Heagerty AM: In vitro perfusion studies of human resistance artery function in essential hypertension. Hypertension 1994, 24:16-23.
22. Deng L-Y, Li J-S, Schiffrin EL: Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats. Clin Sci 1995, 88:611-622.
23. Cockcroft JR, Chowienczyk PJ, Benjamin N, Ritter JM: Preserved endothelium-dependent vasodilation in patients with essential hypertension. N Engl J Med 1994, 330:1036-1040.
24. Bruning TA, Chang PC, Hendriks MGC, Vermeij P, Pfaffendorf M, van Zwieten PA: In vivo characterization of muscarinic receptor subtypes that mediate vasodilation in patients with essential hypertension. Hypertension 1995, 26:70-77.
25. Gerhard M, Roddy MA, Creager SH, Creager MA: Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 1996, 27:849-853.
26. van Zwieten PA, Safar M, Laurent S, Pfaffendorf M, Hendriks MGC, Bruning TA: New insights into the role of endothelial dysfunction in hypertension. J Hypertens 1995, 13:713-716.
27. Heagerty AM, Bund SJ, Aalkjaer C: The effects of drug therapy upon human resistance arteriole morphology in essential hypertension. Direct evidence for structural remodelling of resistance vessels. Lancet 1988, ii:1209-1212.
28. Aalkjaer C, Eiskjaer H, Mulvany MJ, Jespersen B, Kjaer T, Sørensen SS, et al.: Abnormal structure and function of isolated subcutaneous resistance vessels from essential hypertensive patients despite antihypertensive treatment J Hypertens 1989, 7:305-310.
29. i. Circ Res 1993, 73:314-324.
30. 2-adrenoceptors. Br J Pharmacol 1990, 99:31-34.
31. Nielsen H, Mortensen FV, Pilegaard HK, Hasenkam JM, Mulvany MJ: Calcium utilization coupled to stimulation of postjunctional alpha-1 and alpha-2 adrenoceptors in isolated human resistance arteries. J Pharmacol Exp Ther 1992, 260:637-643.
32. 1-adrenoceptor antagonists for the treatment of hypertension: role of vascular receptors in the control of peripheral resistance. Am Heart J 1988, 116:133-162.
33. 2-adrenoceptors by yohimbine. Eur J Pharmacol 1975, 34:383-388.