메뉴 건너뛰기




Volumn 7, Issue 5, 2014, Pages 36-41

Antioxidant properties of gynura procumbens extracts and their inhibitory effects on two major human recombinant cytochrome P450S using a high throughput luminescence assay

Author keywords

Antioxidant properties; CYP1A2; CYP3A4; Gynura procumbens

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; ASCORBIC ACID; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; FLAVONOID; GYNURA PROCUMBENS EXTRACT; PHENOL DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

EID: 84920537321     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (32)
  • 1
    • 53949122693 scopus 로고    scopus 로고
    • In vitro CYP3A4 metabolism: Inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition
    • Hansen TS, Nilsen OG. In vitro CYP3A4 metabolism: Inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic Clin Pharmacol Toxicol 2008;103(5):445-9.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , Issue.5 , pp. 445-449
    • Hansen, T.S.1    Nilsen, O.G.2
  • 2
    • 0033661825 scopus 로고    scopus 로고
    • Herb-drug interactions: Potentially important but woefully under-researched
    • Ernst E. Herb-drug interactions: Potentially important but woefully under-researched. Eur J Clin Pharmacol 2000;56(8):523-4.
    • (2000) Eur J Clin Pharmacol , vol.56 , Issue.8 , pp. 523-524
    • Ernst, E.1
  • 3
    • 0346220388 scopus 로고    scopus 로고
    • Herbal bioactivation: The good, the bad and the ugly
    • Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ. Herbal bioactivation: The good, the bad and the ugly. Life Sci 2004;74(8):935-68.
    • (2004) Life Sci , vol.74 , Issue.8 , pp. 935-968
    • Zhou, S.1    Koh, H.L.2    Gao, Y.3    Gong, Z.Y.4    Lee, E.J.5
  • 4
    • 77955983219 scopus 로고    scopus 로고
    • Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro
    • Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine 2010;17(11):868-75.
    • (2010) Phytomedicine , vol.17 , Issue.11 , pp. 868-875
    • Wang, X.1    Cheung, C.M.2    Lee, W.Y.3    Or, P.M.4    Yeung, J.H.5
  • 5
    • 9444257635 scopus 로고    scopus 로고
    • Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract
    • Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 2004;32(12):1351-8.
    • (2004) Drug Metab Dispos , vol.32 , Issue.12 , pp. 1351-1358
    • Iwata, H.1    Tezuka, Y.2    Kadota, S.3    Hiratsuka, A.4    Watabe, T.5
  • 6
    • 1942497956 scopus 로고    scopus 로고
    • Cytochromes P450, drugs, and diseases
    • Guengerich FP. Cytochromes P450, drugs, and diseases. Mol Interv 2003;3(4):194-204.
    • (2003) Mol Interv , vol.3 , Issue.4 , pp. 194-204
    • Guengerich, F.P.1
  • 7
    • 0030428226 scopus 로고    scopus 로고
    • In vitro techniques for studying drug metabolism
    • Guengerich FP. In vitro techniques for studying drug metabolism. J Pharmacokinet Pharmacodyn 1996;24(5):521-33.
    • (1996) J Pharmacokinet Pharmacodyn , vol.24 , Issue.5 , pp. 521-533
    • Guengerich, F.P.1
  • 8
    • 0028272001 scopus 로고
    • Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins
    • Gonzalez FJ, Gelboin HV. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev 1994;26(1-2):165-83.
    • (1994) Drug Metab Rev , vol.26 , Issue.1-2 , pp. 165-183
    • Gonzalez, F.J.1    Gelboin, H.V.2
  • 9
    • 0018757754 scopus 로고
    • Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a) anthracene in mouse skin
    • Slaga TJ, Gleason GL, DiGiovanni J, Sukumaran KB, Harvey RG. Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a) anthracene in mouse skin. Cancer Res 1979;39:1934-6.
    • (1979) Cancer Res , vol.39 , pp. 1934-1936
    • Slaga, T.J.1    Gleason, G.L.2    Digiovanni, J.3    Sukumaran, K.B.4    Harvey, R.G.5
  • 10
    • 84867116544 scopus 로고    scopus 로고
    • Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes
    • Kim H, Choi HK, Jeong TC, Jahng Y, Kim DH, Lee SH, et al. Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes. Food Chem Toxicol 2013;51:33-7.
    • (2013) Food Chem Toxicol , vol.51 , pp. 33-37
    • Kim, H.1    Choi, H.K.2    Jeong, T.C.3    Jahng, Y.4    Kim, D.H.5    Lee, S.H.6
  • 11
    • 84920538300 scopus 로고    scopus 로고
    • Comparison of three plant tissue culture media for efficient micropropagation of an important tropical medicinal plant, Gynura procumbens (Lour) Merr
    • Bhore S, Vaishana K. Comparison of three plant tissue culture media for efficient micropropagation of an important tropical medicinal plant, Gynura procumbens (Lour) Merr. Am Eurasia J Agric Environ Sci 2010;8(4):474-81.
    • (2010) Am Eurasia J Agric Environ Sci , vol.8 , Issue.4 , pp. 474-481
    • Bhore, S.1    Vaishana, K.2
  • 12
    • 84860720226 scopus 로고    scopus 로고
    • Induction, characterization, and NMR-based metabolic profiling of adventitious root cultures from leaf explants of Gynura procumbens
    • Saiman MZ, Mustafa NR, Schulte AE, Verpoorte R, Choi YH. Induction, characterization, and NMR-based metabolic profiling of adventitious root cultures from leaf explants of Gynura procumbens. Plant Cell Tissue Organ Cult 2012;109(3):465-75.
    • (2012) Plant Cell Tissue Organ Cult , vol.109 , Issue.3 , pp. 465-475
    • Saiman, M.Z.1    Mustafa, N.R.2    Schulte, A.E.3    Verpoorte, R.4    Choi, Y.H.5
  • 13
    • 33846244221 scopus 로고    scopus 로고
    • Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats
    • Kim MJ, Lee HJ, Wiryowidagdo S, Kim HK. Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats. J Med Food 2006;9(4):587-90.
    • (2006) J Med Food , vol.9 , Issue.4 , pp. 587-590
    • Kim, M.J.1    Lee, H.J.2    Wiryowidagdo, S.3    Kim, H.K.4
  • 14
    • 67349167120 scopus 로고    scopus 로고
    • Toxicology evaluation of standardized methanol extract of Gynura procumbens
    • Rosidah, Yam MF, Sadikun A, Ahmad M, Akowuah GA, Asmawi M.. Toxicology evaluation of standardized methanol extract of Gynura procumbens. J Ethnopharmacol 2009;123(2):244-9.
    • (2009) J Ethnopharmacol , vol.123 , Issue.2 , pp. 244-249
    • Rosidah, Y.M.F.1    Sadikun, A.2    Ahmad, M.3    Akowuah, G.A.4    Asmawi, M.5
  • 15
    • 78650652550 scopus 로고    scopus 로고
    • Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats
    • Hassan Z, Yam MF, Ahmad M, Yusof AP. Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats. Molecules 2010;15(12):9008-23.
    • (2010) Molecules , vol.15 , Issue.12 , pp. 9008-9023
    • Hassan, Z.1    Yam, M.F.2    Ahmad, M.3    Yusof, A.P.4
  • 16
    • 84870368883 scopus 로고    scopus 로고
    • Antidiabetic effect of Gynura procumbens leaves extracts involve modulation of hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats
    • Lee HW, Hakim P, Rabu A, Sani HA. Antidiabetic effect of Gynura procumbens leaves extracts involve modulation of hepatic carbohydrate metabolism in streptozotocin-induced diabetic rats. J Med Plants Res 2012;6(5):796-812.
    • (2012) J Med Plants Res , vol.6 , Issue.5 , pp. 796-812
    • Lee, H.W.1    Hakim, P.2    Rabu, A.3    Sani, H.A.4
  • 17
    • 79960739878 scopus 로고    scopus 로고
    • Acute toxicity study and wound healing potential of Gynura procumbens leaf extract in rats
    • Zahra A, Kadir F, Mahmood A, Al Hadi A, Suzy S, Sabri S, et al. Acute toxicity study and wound healing potential of Gynura procumbens leaf extract in rats. J Med Plants Res 2011;5(12):2551-8.
    • (2011) J Med Plants Res , vol.5 , Issue.12 , pp. 2551-2558
    • Zahra, A.1    Kadir, F.2    Mahmood, A.3    Al Hadi, A.4    Suzy, S.5    Sabri, S.6
  • 19
    • 51649126049 scopus 로고    scopus 로고
    • Antioxidant potential of Gynura procumbens
    • Yam M, Sadikun A, Asmawi M. Antioxidant potential of Gynura procumbens. Pharm Biol 2008;46(9):616-25.
    • (2008) Pharm Biol , vol.46 , Issue.9 , pp. 616-625
    • Yam, M.1    Sadikun, A.2    Asmawi, M.3
  • 20
    • 0031785065 scopus 로고    scopus 로고
    • Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids
    • Zhai S, Dai R, Friedman FK, Vestal RE. Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. Drug Metab Dispos 1998;26(10):989-92.
    • (1998) Drug Metab Dispos , vol.26 , Issue.10 , pp. 989-992
    • Zhai, S.1    Dai, R.2    Friedman, F.K.3    Vestal, R.E.4
  • 21
    • 0035734306 scopus 로고    scopus 로고
    • Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds
    • Ho PC, Saville DJ, Wanwimolruk S. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci 2001;4(3):217-27.
    • (2001) J Pharm Pharm Sci , vol.4 , Issue.3 , pp. 217-227
    • Ho, P.C.1    Saville, D.J.2    Wanwimolruk, S.3
  • 22
    • 77954819680 scopus 로고    scopus 로고
    • Enhancement of antioxidant activity, total phenolic and flavonoid content of black soybeans by solid state fermentation with Bacillus subtilis BCRC 14715
    • Juan MY, Chou CC. Enhancement of antioxidant activity, total phenolic and flavonoid content of black soybeans by solid state fermentation with Bacillus subtilis BCRC 14715. Food Microbiol 2010;27(5):586-91.
    • (2010) Food Microbiol , vol.27 , Issue.5 , pp. 586-591
    • Juan, M.Y.1    Chou, C.C.2
  • 23
    • 33751390842 scopus 로고
    • Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion
    • Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agric Food Chem 1992;40(6):945-8.
    • (1992) J Agric Food Chem , vol.40 , Issue.6 , pp. 945-948
    • Shimada, K.1    Fujikawa, K.2    Yahara, K.3    Nakamura, T.4
  • 24
    • 7044220478 scopus 로고    scopus 로고
    • Antioxidant activities of buckwheat extracts
    • Sun T, Ho CT. Antioxidant activities of buckwheat extracts. Food Chem 2005;90(4):743-9.
    • (2005) Food Chem , vol.90 , Issue.4 , pp. 743-749
    • Sun, T.1    Ho, C.T.2
  • 26
    • 33745034571 scopus 로고    scopus 로고
    • Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants
    • Pourmorad F, Hosseinimehr S, Shahabimajd N. Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. Afr J Biotechnol 2006;5(11):1142-5.
    • (2006) Afr J Biotechnol , vol.5 , Issue.11 , pp. 1142-1145
    • Pourmorad, F.1    Hosseinimehr, S.2    Shahabimajd, N.3
  • 27
    • 37449013831 scopus 로고    scopus 로고
    • Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide
    • Pekthong D, Martin H, Abadie C, Bonet A, Heyd B, Mantion G, et al. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J Ethnopharmacol 2008;115(3):432-40.
    • (2008) J Ethnopharmacol , vol.115 , Issue.3 , pp. 432-440
    • Pekthong, D.1    Martin, H.2    Abadie, C.3    Bonet, A.4    Heyd, B.5    Mantion, G.6
  • 28
    • 33846872531 scopus 로고    scopus 로고
    • Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery
    • Krippendorff BF, Lienau P, Reichel A, Huisinga W. Optimizing classification of drug-drug interaction potential for CYP450 isoenzyme inhibition assays in early drug discovery. J Biomol Screen 2007;12(1):92-9.
    • (2007) J Biomol Screen , vol.12 , Issue.1 , pp. 92-99
    • Krippendorff, B.F.1    Lienau, P.2    Reichel, A.3    Huisinga, W.4
  • 29
    • 34247646955 scopus 로고    scopus 로고
    • Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products
    • Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 2007;235(1-2):83-91.
    • (2007) Toxicology , vol.235 , Issue.1-2 , pp. 83-91
    • Appiah-Opong, R.1    Commandeur, J.N.2    van Vugt-Lussenburg, B.3    Vermeulen, N.P.4
  • 30
    • 0023951396 scopus 로고
    • Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
    • Guengerich FP. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res 1988;48(11):2946-54.
    • (1988) Cancer Res , vol.48 , Issue.11 , pp. 2946-2954
    • Guengerich, F.P.1
  • 31
    • 0028268359 scopus 로고
    • Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids
    • Tsyrlov IB, Mikhailenko VM, Gelboin HV. Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids. Biochim Biophys Acta 1994;1205(2):325-35.
    • (1994) Biochim Biophys Acta , vol.1205 , Issue.2 , pp. 325-335
    • Tsyrlov, I.B.1    Mikhailenko, V.M.2    Gelboin, H.V.3
  • 32
    • 1542348613 scopus 로고    scopus 로고
    • An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies
    • Strandell J, Neil A, Carlin G. An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies. Phytomedicine 2004;11(2-3):98-104.
    • (2004) Phytomedicine , vol.11 , Issue.2-3 , pp. 98-104
    • Strandell, J.1    Neil, A.2    Carlin, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.