α-glucan pathway as a novel Mtb drug target: Structural insights and cues for polypharmcological targeting of GlgB and GlgE

Current Medicinal Chemistry

Volumn 21, Issue 35, 2014, Pages 4074-4084

  Agrawal, Pushpa ^a   Gupta, Pawan ^a   Swaminathan, Kunchithapadam ^b   Parkesh, Raman ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Capsular glucan; GlgB; GlgE; Glycogen branching enzyme; High throughput screening assays; Horseradish peroxidase (HRPO) assay; Iodine assay; Mtb; Polypharamcology; Small molecule; glucan

Indexed keywords

1,4 ALPHA GLUCAN BRANCHING ENZYME; ALPHA 1,4 GLUCAN:MALTOSE 1 PHOSPHATE MALTOSYLTRANSFERASE; BACTERIAL ENZYME; GLUCAN; GLYCOGEN; GLYCOSYLTRANSFERASE; POLYSACCHARIDE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; TUBERCULOSTATIC AGENT;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOCHEMISTRY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG DEVELOPMENT; ENZYME REGULATION; GLYCOGEN SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULARLY TARGETED THERAPY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TUBERCULOSIS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CLASSIFICATION; ENZYMOLOGY; METABOLISM; MICROBIOLOGY; MOLECULAR DYNAMICS; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

1,4-ALPHA-GLUCAN BRANCHING ENZYME; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; GLYCOGEN; HUMANS; MOLECULAR DYNAMICS SIMULATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; TUBERCULOSIS;

EID: 84920536130     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867321666140826120449     Document Type: Article

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