Ionizing irradiation inhibits keloid fibroblast cell proliferation and induces premature cellular senescence

Journal of Dermatology

Volumn 42, Issue 1, 2015, Pages 56-63

  Ji, Jiang ^a   Tian, Ye ^a   Zhu, Ya Qun ^a   Zhang, Li Yuan ^a   Ji, Sheng Jun ^a   Huan, Jian ^a   Zhou, Xiao Zhong ^a   Cao, Jian Ping ^b  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Cell cycle; cellular senescence; ionizing irradiation; primary keloid fibroblast

Indexed keywords

BETA GALACTOSIDASE; MESSENGER RNA; PROTEIN P16; PROTEIN P21; PROTEIN P27;

ARTICLE; CELL AGING; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; KELOID; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; X IRRADIATION; ADOLESCENT; ADULT; CELL CULTURE; CELL CYCLE; CHILD; FEMALE; MALE; RADIATION RESPONSE; YOUNG ADULT;

ADOLESCENT; ADULT; CELL AGING; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CHILD; FEMALE; FIBROBLASTS; HUMANS; KELOID; MALE; X-RAY THERAPY; YOUNG ADULT;

EID: 84920534683     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/1346-8138.12702     Document Type: Article

References (27)

1. Seifert O, Mrowietz U,. Keloid scarring: bench and bedside. Arch Dermatol Res 2009; 301: 259-272.
2. Slemp AE, Kirschner RE,. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr 2006; 18: 396-402.
3. Stahl S, Barnea Y, Weiss J, et al,. Treatment of earlobe keloids by extralesional excision combined with preoperative and postoperative "sandwich" radiotherapy. Plast Reconstr Surg 2010; 125: 135-141.
4. Sclafani AP, Gordon L, Chadha M, Romo T III,. Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg 1996; 22: 569-574.
5. Guix B, Henriquez I, Andres A, et al,. Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 2001; 50: 167-172.
6. Kal HB, Veen RE,. Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship. Strahlenther Onkol 2005; 181: 717-723.
7. Sakamoto T, Oya N, Shibuya K, et al,. Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 2009; 91: 271-276.
8. Bran GM, Goessler UR, Hormann K, et al,. Keloids: current concepts of pathogenesis (review). Int J Mol Med 2009; 24: 283-293.
9. Luo S, Benathan M, Raffoul W, et al,. Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg 2001; 107: 87-96.
10. Raffetto JD, Leverkus M, Park HY, Menzoian JO,. Synopsis on cellular senescence and apoptosis. J Vasc Surg 2001; 34: 173-177.
11. Pietenpol JA, Stewart ZA,. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology 2002; 181-182: 475-481.
12. DeJesus V, Rios I, Davis C, et al,. Induction of apoptosis in human replicative senescent fibroblasts. Exp Cell Res 2002; 274: 92-99.
13. Liu R, Cao Z, Pan Y, et al,. Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells. Anticancer Drugs 2013; 24: 667-676.
14. Schmitt CA, Fridman JS, Yang M, et al,. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109: 335-346.
15. te Poele RH, Okorokov AL, Jardine L, et al,. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002; 62: 76-83.
16. Dimri GP,. What has senescence got to do with cancer. Cancer Cell 2005; 7: 505-512.
17. Debacq-Chainiaux F, Borlon C, Pascal T, et al,. Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci 2005; 118: 743-758.
18. Toussaint O, Medrano EE, von Zglinicki T,. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 2000; 35: 927-945.
19. Ma S, Chang WP, Fang RH,. Measurement of radiation-induced DNA double-strand breaks in human diploid fibroblasts from keloid and normal skin by single-cell gel electrophoresis. Plast Reconstr Surg 1996; 98: 821-826.
20. Bartkova J, Horejsi Z, Koed K, et al,. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434: 864-870.
21. De Felice B, Garbi C, Santoriello M, et al,. Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Mol Cell Biochem 2009; 327: 191-201.
22. Ladin DA, Hou Z, Patel D, et al,. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen 1998; 6: 28-37.
23. Bringold F, Serrano M,. Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol 2000; 35: 317-329.
24. Saed GM, Ladin D, Olson J, et al,. Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Arch Dermatol 1998; 134: 963-967.
25. Tavana O, Benjamin CL, Puebla-Osorio N, et al,. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle 2010; 9: 3328-3336.
26. Blazic TM, Brajac I,. Defective induction of senescence during wound healing is a possible mechanism of keloid formation. Med Hypotheses 2006; 66: 649-652.
27. Varmeh S, Egia A, McGrouther D, et al,. Cellular senescence as a possible mechanism for halting progression of keloid lesions. Genes Cancer 2011; 2: 1061-1066.