PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 157-167

  Chandra, Abhishek ^a   Lin, Tiao ^a,c   Zhu, Ji ^a   Tong, Wei ^a,d   Huo, Yanying ^e   Jia, Haoruo ^a   Zhang, Yejia ^a,f   Liu, X Sherry ^a   Cengel, Keith ^b   Xia, Bing ^e   Qin, Ling ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c ZHEJIANG UNIVERSITY   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL DEATH; CELL SIGNALING; DISEASES; DNA; MACHINERY; OSTEOBLASTS; PROTEINS; RADIATION; RADIATION EFFECTS; REPAIR;

CANONICAL WNT SIGNALING; DNA DOUBLE STRAND BREAKS; MOLECULAR MECHANISM; OSTEOCYTIC CELLS; OSTEOPROGENITORS; PARATHYROID HORMONES; PROTEIN KINASE A; RADIATION-INDUCED;

RADIOTHERAPY;

BETA CATENIN; CASPASE 3; KU ANTIGEN; PARATHYROID HORMONE[1-34]; REACTIVE OXYGEN METABOLITE; WNT3A PROTEIN; CELL NUCLEUS ANTIGEN; CTNNB1 PROTEIN, RAT; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA BINDING PROTEIN; PARATHYROID HORMONE; RADIOPROTECTIVE AGENT; RECOMBINANT PROTEIN; XRCC6 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; HUMAN; IMMUNOFLUORESCENCE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIATION INJURY; RADIATION PROTECTION; RAT; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEWBORN; OSTEOCYTE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; SKULL; TISSUE CULTURE TECHNIQUE; TUMOR CELL LINE; X RAY;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, NUCLEAR; APOPTOSIS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; KU AUTOANTIGEN; OSTEOBLASTS; OSTEOCYTES; PARATHYROID HORMONE; RADIATION-PROTECTIVE AGENTS; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SKULL; TISSUE CULTURE TECHNIQUES; WNT3A PROTEIN; X-RAYS;

EID: 84920507168     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.608158     Document Type: Article

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