Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 1, 2015, Pages 148-153

  Wang, Juanfei ^a,b   Ren, Jinqi ^b   Wu, Bin ^b   Feng, Shanshan ^b   Cai, Guoping ^a   Tuluc, Florin ^c   Peränen, Johan ^d   Guo, Wei ^b  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

ERK; Guanine nucleotide exchange factor; Phosphorylation; Rab gtpases; Rab8

Indexed keywords

EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAB11A PROTEIN; RAB8 PROTEIN; RABIN8 PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG; GERMINAL CENTER KINASES; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RAB PROTEIN; RAB11 PROTEIN;

ARTICLE; CELL MEMBRANE; CELL MIGRATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CELL MEMBRANE; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RAB GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSFERRIN;

EID: 84920427622     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412089112     Document Type: Article

References (39)

1. Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10(8):513-525.
2. Barr F, Lambright DG (2010) Rab GEFs and GAPs. Curr Opin Cell Biol 22(4):461-470.
3. Mizuno-Yamasaki E, Rivera-Molina F, Novick P (2012) GTPase networks in membrane traffic. Annu Rev Biochem 81:637-659.
4. Pfeffer SR (2013) Rab GTPase regulation of membrane identity. Curr Opin Cell Biol 25(4):414-419.
5. Cherfils J, Zeghouf M (2013) Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 93(1):269-309.
6. Hutagalung AH, Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91(1):119-149.
7. Peränen J (2011) Rab8 GTPase as a regulator of cell shape. Cytoskeleton (Hoboken) 68(10):527-539.
8. Hattula K, Furuhjelm J, Arffman A, Peränen J (2002) A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Mol Biol Cell 13(9):3268-3280.
9. Randhawa VK, et al. (2008) GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem 283(40):27208-27219.
10. Sun Y, Bilan PJ, Liu Z, Klip A (2010) Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Proc Natl Acad Sci USA 107(46):19909-19914.
11. Huber LA, et al. (1993) Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol 123(1):35-45.
12. Nachury MV, et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129(6):1201-1213.
13. Blümer J, et al. (2013) RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol 200(3):287-300.
14. Ortiz D, Medkova M, Walch-Solimena C, Novick P (2002) Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol 157(6):1005-1015.
15. Mizuno-Yamasaki E, Medkova M, Coleman J, Novick P (2010) Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev Cell 18(5):828-840.
16. Knödler A, et al. (2010) Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc Natl Acad Sci USA 107(14):6346-6351.
17. Westlake CJ, et al. (2011) Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci USA 108(7):2759-2764.
18. Feng S, et al. (2012) A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis. J Biol Chem 287(19):15602-15609.
19. Barr FA (2013) Review series: Rab GTPases and membrane identity: Causal or inconsequential? J Cell Biol 202(2):191-199.
20. Das A, Guo W (2011) Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond. Trends Cell Biol 21(7):383-386.
21. Bryant DM, et al. (2010) A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol 12(11):1035-1045.
22. Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12(1):260-271.
23. Ren J, Guo W (2012) ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70. Dev Cell 22(5):967-978.
24. Khokhlatchev A, et al. (1997) Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem 272(17):11057-11062.
25. Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410(6824): 37-40.
26. Kohno M, Pouyssegur J (2006) Targeting the ERK signaling pathway in cancer therapy. Ann Med 38(3):200-211.
27. Hattula K, et al. (2006) Characterization of the Rab8-specific membrane traffic route linked to protrusion formation. J Cell Sci 119(Pt 23):4866-4877.
28. Hokanson DE, Bretscher AP (2012) EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Mol Biol Cell 23(4):701-715.
29. Ayoub MA, Pfleger KD (2010) Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization. Curr Opin Pharmacol 10(1):44-52.
30. Ferré S, et al. (2010) G protein-coupled receptor heteromers as new targets for drug development. Prog Mol Biol Transl Sci 91:41-52.
31. Lohse MJ, Nuber S, Hoffmann C (2012) Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacol Rev 64(2):299-336.
32. Fernandez I, et al. (1998) Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell 94(6):841-849.
33. Hu SH, Latham CF, Gee CL, James DE, Martin JL (2007) Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci USA 104(21):8773-8778.
34. Dragulescu-Andrasi A, Chan CT, De A, Massoud TF, Gambhir SS (2011) Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects. Proc Natl Acad Sci USA 108(29):12060-12065.
35. Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick PJ (2013) Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. Proc Natl Acad Sci USA 110(50):19995-20002.
36. Chiba S, Amagai Y, Homma Y, Fukuda M, Mizuno K (2013) NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J 32(6):874-885.
37. Ultanir SK, et al. (2012) Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron 73(6):1127-1142.
38. Bishop A, et al. (2010) Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase. EMBO J 29(17):2930-2942.
39. Farhan H, Rabouille C (2011) Signalling to and from the secretory pathway. J Cell Sci 124(Pt 2):171-180.