Body composition and bone mineral density in women with Cushing's syndrome in remission and the association with common genetic variants influencing glucocorticoid sensitivity

European Journal of Endocrinology

Volumn 172, Issue 1, 2015, Pages 1-10

  Ragnarsson, Oskar ^a,b,e   Glad, Camilla A M ^a   Bergthorsdottir, Ragnhildur ^a   Almqvist, Erik G ^b   Ekerstad, Eva ^c   Widell, Håkan ^d   Wängberg, Bo ^e   Johannsson, Gudmundur ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SKARABORG HOSPITAL   (Sweden)

^c Department of Internal Medicine Norra ä lvsborgs Hospital   (Sweden)

^d Södra lvsborg Hospital   (Sweden)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID;

ABCB1 GENE; ABDOMINAL FAT; ADULT; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; BONE DENSITY; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CUSHING SYNDROME; DISEASE DURATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; FEMALE; FEMUR NECK; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HORMONE SUBSTITUTION; HSD11B1 GENE; HUMAN; MUSCLE MASS; NR3C1 GENE; NR3C2 GENE; REMISSION; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; BLOOD; GENE FREQUENCY; GENETICS; MIDDLE AGED; PHYSIOLOGY; PROCEDURES;

BODY COMPOSITION; BONE DENSITY; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; CUSHING SYNDROME; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GLUCOCORTICOIDS; HUMANS; MIDDLE AGED; REMISSION INDUCTION;

EID: 84920388968     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-14-0747     Document Type: Article

References (39)

1. Kristo C, Jemtland R, Ueland T., Godang K & Bollerslev J. Restoration of the coupling process and normalization of bone mass following successful treatment of endogenous Cushing's syndrome: a prospective, long-term study. European Journal of Endocrinology 2006 154 109-118. (doi:10.1530/eje.1.02067)
2. Vestergaard P, Lindholm J, Jorgensen J.O., Hagen C., Hoeck HC, Laurberg P, Rejnmark L, Brixen K., Kristensen LO, Feldt-Rasmussen U et al. Increased risk of osteoporotic fractures in patients with Cushing's syndrome. European Journal of Endocrinology 2002 146 51-56. (doi:10.1530/eje.0.1460051)
3. Geer EB, Shen W, Gallagher D., Punyanitya M, Looker HC, Post KD & Freda PU. MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease. Clinical Endocrinology 2010 73 469-475. (doi:10.1111/j.1365-2265.2010.03829.x)
4. Pirlich M, Biering H, Gerl H., Ventz M, Schmidt B, Ertl S & Lochs H. Loss of body cell mass in Cushing's syndrome: effect of treatment. Journal of Clinical Endocrinology and Metabolism 2002 87 1078-1084. (doi:10.1210/jcem.87.3.8321)
5. Burt MG, Gibney J & Ho KK. Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism. Clinical Endocrinology 2006 64 436-443. (doi:10.1111/j.1365-2265.2006.02488.x)
6. Mayo-Smith W., Hayes CW, Biller B.M., Klibanski A., Rosenthal H & Rosenthal DI. Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome. Radiology 1989 170 515-518. (doi:10.1148/radiology.170.2.2911678)
7. Geer EB, Shen W, Strohmayer E., Post KD & Freda PU. Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospectivestudyusingwhole-body MRI. Journal of Clinical Endocrinology and Metabolism 2012 97 1702-1711. (doi:10.1210/jc.2011-3123)
8. Ueland T, Kristo C, Godang K., Aukrust P & Bollerslev J. Interleukin-1 receptor antagonist is associated with fat distribution in endogenous Cushing's syndrome: a longitudinal study. Journal of Clinical Endocrinology and Metabolism 2003 88 1492-1496. (doi:10.1210/jc.2002-021030)
9. Burt MG, Gibney J & Ho KK. Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatment. American Journal of Physiology. Endocrinology and Metabolism 2007 292 E1426-E1432. (doi:10.1152/ajpendo.00524.2006)
10. Lonn L, Kvist H, Ernest I & Sjostrom L. Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome. Metabolism 1994 43 1517-1522. (doi:10.1016/0026-0495(94)90010-8)
11. Barahona MJ, Sucunza N, Resmini E., Fernandez-Real JM, Ricart W, Moreno-Navarrete JM, Puig T., Farrerons J & Webb SM. Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 2009 94 3365-3371. (doi:10.1210/jc.2009-0766)
12. Hermus AR, Smals AG, Swinkels L.M., Huysmans DA, Pieters GF, Sweep CF, Corstens FH & Kloppenborg PW. Bone mineral density and bone turnover before and after surgical cure of Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 1995 80 2859-2865. (doi:10.1210/jcem.80.10.7559865)
13. Futo L, Toke J, Patocs A., Szappanos A, Varga I, Glaz E., Tulassay Z, Racz K & Toth M. Skeletal differences in bone mineral area and content before and after cure of endogenous Cushing's syndrome. Osteoporosis International 2008 19 941-949. (doi:10.1007/s00198-007-0514-x)
14. Kawamata A, Iihara M, Okamoto T & Obara T. Bone mineral density before and after surgical cure of Cushing's syndrome due to adrenocortical adenoma: prospective study. World Journal of Surgery 2008 32 890-896. (doi:10.1007/s00268-007-9394-7)
15. Barahona MJ, Sucunza N, Resmini E., Fernandez-Real JM, Ricart W, Moreno-Navarrete JM, Puig T., Wagner AM, Rodriguez-Espinosa J, Farrerons J et al. Deleterious effects of glucocorticoid replacement on bone in women after long-term remission of Cushing's syndrome. Journal of Bone and Mineral Research 2009 24 1841-1846. (doi:10.1359/jbmr.090505)
16. van Rossum EF & Lamberts SW. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Progress in Hormone Research 2004 59 333-357. (doi:10.1210/rp.59.1.333)
17. Szappanos A, Patocs A, Toke J., Boyle B, Sereg M, Majnik J., Borgulya G, Varga I, Liko I., Racz K et al. BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism. Clinical Endocrinology 2009 71 636-643. (doi:10.1111/j.1365-2265.2009.03528.x)
18. Trementino L, Appolloni G, Concettoni C., Cardinaletti M, Boscaro M & Arnaldi G. Association of glucocorticoid receptor polymorphism A3669G with decreased risk of developing diabetes in patients with Cushing's syndrome. European Journal of Endocrinology 2012 166 35-42. (doi:10.1530/EJE-11-0722)
19. DeRijk RH, Wust S, Meijer O.C., Zennaro MC, Federenko IS, Hellhammer DH, Giacchetti G, Vreugdenhil E., Zitman FG & de Kloet ER. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. Journal of Clinical Endocrinology and Metabolism 2006 91 5083-5089. (doi:10.1210/jc.2006-0915)
20. Dekker MJ, Tiemeier H, Luijendijk H.J., Kuningas M., Hofman A, de Jong FH, Stewart PM, Koper JW & Lamberts SW. The effect of common genetic variation in 11b-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis activity and incident depression. Journal of Clinical Endocrinology and Metabolism 2012 97 E233-E237. (doi:10.1210/jc.2011-0601)
21. Martinez F, Mansego ML, Escudero J.C., Redon J & Chaves FJ. Association of a mineralocorticoid receptor gene polymorphism with hypertension in a Spanish population. American Journal of Hypertension 2009 22 649-655. (doi:10.1038/ajh.2009.39)
22. Lovas K, Gjesdal CG, Christensen M, Wolff A.B., Almas B., Svartberg J, Fougner KJ, Syversen U, Bollerslev J., Falch JA et al. Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone. European Journal of Endocrinology 2009 160 993-1002. (doi:10.1530/EJE-08-0880)
23. Ragnarsson O, Glad C, Berglund P., Bergthorsdottir R, Eder DN & Johannsson G. Common genetic variants in the glucocorticoid receptor and the 11b-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission. Journal of Clinical Endocrinology and Metabolism 2014 99 E1803-E1807. (doi:10.1210/jc.2014-1906)
24. Ragnarsson O, Berglund P, Eder DN & Johannsson G. Long-term cognitive impairments and attentional deficits in patients with Cushing's disease and cortisol-producing adrenal adenoma in remission. Journal of Clinical Endocrinology and Metabolism 2012 97 E1640-E1648. (doi:10.1210/jc.2012-1945)
25. Kim J, Heshka S, Gallagher D., Kotler DP, Mayer L, Albu J, Shen W., Freda PU & Heymsfield SB. Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. Journal of Applied Physiology 2004 97 655-660. (doi:10.1152/japplphysiol.00260.2004)
26. Zimmet P, Magliano D, Matsuzawa Y., Alberti G & Shaw J. The metabolic syndrome: a global public health problem and a new definition. Journal of Atherosclerosis and Thrombosis 2005 12 295-300. (doi:10.5551/jat.12.295)
27. Toth M & Grossman A. Glucocorticoid-induced osteoporosis: lessons from Cushing's syndrome. Clinical Endocrinology 2013 79 1-11. (doi:10.1111/cen.12189)
28. Faggiano A, Pivonello R, Spiezia S., De Martino MC, Filippella M, Di Somma C, Lombardi G & Colao A. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. Journal of Clinical Endocrinology and Metabolism 2003 88 2527-2533. (doi:10.1210/jc.2002-021558)
29. Giordano R, Picu A, Marinazzo E., D'Angelo V, Berardelli R, Karamouzis I., Forno D, Zinna D, Maccario M, Ghigo E. et al. Metabolicand cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during actived is ease and 1 year after remission. Clinical Endocrinology 2011 75 354-360. (doi:10.1111/j.1365-2265.2011.04055.x)
30. Colao A, Pivonello R, Spiezia S., Faggiano A, Ferone D, Filippella M., Marzullo P, Cerbone G, Siciliani M & Lombardi G. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. Journal of Clinical Endocrinology and Metabolism 1999 84 2664-2672. (doi:10.1210/jcem.84.8.5896)
31. Barahona MJ, Resmini E, Vilades D., Pons-Llado G, Leta R, Puig T & Webb SM. Coronary artery disease detected by multislice computed tomography in patients after long-term cure of Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 2013 98 1093-1099. (doi:10.1210/jc.2012-3547)
32. Dekkers OM, Horvath-Puho E, Jorgensen J.O., Cannegieter SC, Ehrenstein V, Vandenbroucke JP, Pereira AM & Sorensen HT. Multisystem morbidity and mortality in Cushing's syndrome: a cohort study. Journal of Clinical Endocrinology and Metabolism 2013 98 2277-2284. (doi:10.1210/jc.2012-3582)
33. Voorhoeve PG, van den Akker EL, van Rossum EF, Koper JW, van Mechelen W, Lamberts SW & Delemarre-van de Waal HA. Glucocorticoid receptor gene variant is associated with increased body fatness in youngsters. Clinical Endocrinology 2009 71 518-523. (doi:10.1111/j.1365-2265.2009.03538.x)
34. Kuningas M, Mooijaart SP, Slagboom P.E., Westendorp RG & van Heemst D. Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study. Biogerontology 2006 7 231-238. (doi:10.1007/s10522-006-9021-2)
35. Giordano R, Marzotti S, Berardelli R., Karamouzis I, Brozzetti A, D'Angelo V, Mengozzi G, Mandrile G., Giachino D, Migliaretti G et al. BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidae-mia in patients with Addison's disease. Clinical Endocrinology 2012 77 863-870. (doi:10.1111/j.1365-2265.2012.04439.x)
36. Ueda K, Okamura N, Hirai M., Tanigawara Y, Saeki T, Kioka N., Komano T & Hori R. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. Journal of Biological Chemistry 1992 267 24248-24252.
37. Esser C & Tomluk J. Reporting Hardy-Weinberg tests in case-control studies: reasons for caution but not for panic reactions. Journal of Investigative Dermatology 2005 124 1082-1083. (doi:10.1111/j.0022-202X.2005.23709.x)
38. Pecori Giraldi F., Moro M & Cavagnini F. Gender-related differences in the presentation and course of Cushing's disease. Journal of Clinical Endocrinology and Metabolism 2003 88 1554-1558. (doi:10.1210/jc.2002-021518)
39. Minetto M, Reimondo G, Osella G., Ventura M, Angeli A & Terzolo M. Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing's syndrome. Osteoporosis International 2004 15 855-861. (doi:10.1007/s00198-004-1616-3)