Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

Biogerontology

Volumn 7, Issue 4, 2006, Pages 231-238

  Kuningas, Maris ^a,b   Mooijaart, Simon P ^a   Slagboom, P Eline ^a   Westendorp, Rudi G J ^a   van Heemst, Diana ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

Ageing; Cardiovascular disease; Glucocorticoid receptor; Metabolism; Survival

Indexed keywords

GLUCOCORTICOID RECEPTOR; HEMOGLOBIN A1C; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; AGING; ARTICLE; BODY COMPOSITION; BODY HEIGHT; CALCULATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEMOGLOBIN DETERMINATION; HORMONE SENSITIVITY; HUMAN; INTERMITTENT CLAUDICATION; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MORTALITY; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE; SURVIVAL RATE; TRIACYLGLYCEROL BLOOD LEVEL;

AGE DISTRIBUTION; AGED, 80 AND OVER; APOLIPOPROTEINS E; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HETEROZYGOTE; HUMANS; INCIDENCE; MALE; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID; RISK ASSESSMENT; RISK FACTORS; SURVIVAL ANALYSIS; SURVIVAL RATE; VARIATION (GENETICS);

EID: 33747281792     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-006-9021-2     Document Type: Article

References (29)

1. Bootsma-van der Wiel A, van Exel E, De Craen AJ, Gussekloo J, Lagaay AM, Knook DL, Westendorp RG (2002) A high response is not essential to prevent selection bias: Results from the Leiden 85-plus study. J Clin Epidemiol 55:1119-1125
2. Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351-1363
3. Chrousos GP (1998) Stressors, stress, and neuroendocrine integration of the adaptive response: The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci 851:311-335
4. de Kloet ER, Vreugdenhil E, Oitzl MS, Joels M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269-301
5. de Lange P, Koper JW, Huizenga NA, Brinkmann AO, de Jong FH, Karl M, Chrousos GP, Lamberts SW (1997) Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants. Mol Endocrinol 11:1156-1164
6. Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podesta F, Koper JW, Liuzzi A, Lamberts SW (2003) The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf) 59:68-74
7. Dobson MG, Redfern CP, Unwin N, Weaver JU (2001) The N363S polymorphism of the glucocorticoid receptor: Potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. J Clin Endocrinol Metab 86:2270-2274
8. Echwald SM, Sorensen TI, Andersen T, Pedersen O (2001) The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men. Int J Obes Relat Metab Disord 25:1563-1565
9. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
10. Heijmans BT, Gussekloo J, Kluft C, Droog S, Lagaay AM, Knook DL, Westendorp RG, Slagboom EP (1999) Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR). Eur J Hum Genet 7:197-204
11. Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, de Jong FH, Lamberts SW (1998a) A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 83:144-151
12. Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, de Jong FH, Lamberts SW (1998b) Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axisto a low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab 83:47-54
13. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001) Replication validity of genetic association studies. Nat Genet 29:306-309
14. Koper JW, Stolk RP, de Lange P, Huizenga NA, Molijn GJ, Pols HA, Grobbee DE, Karl M, de Jong FH, Brinkmann AO, Lamberts SW (1997) Lack of association between five polymorphisms in the human glucocorticoid recepton gene and glucocorticoid resistance. Hum Genet 99:663-668
15. Lin RC, Wang WY, Morris BJ (1999) High penetrance, overweight, and glucocorticoid receptor variant: Case-control study. BMJ 319:1337-1338
16. Lin RC, Wang XL, Morris BJ (2003) Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension 41:404-407
17. Macfarlane PW, Latif S (1996) Automated serial ECG comparison based on the Minnesota code. J Electrocardiol 29(Suppl):29-34
18. McEwen BS (1998) Protective and damaging effects of stress mediators. N Engl J Med 338:171-179
19. Munck A, Guyre PM, Holbrook NJ (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5:25-44
20. Panarelli M, Holloway CD, Fraser R, Connell JM, Ingram MC, Anderson NH, Kenyon CJ (1998) Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 83:1846-1852
21. Rosmond R, Bouchard C, Bjorntorp P (2001) Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: Cohort study. BMJ 322:652-653
22. Russcher H, van Rossum EF, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW (2005) Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism. Mol Endocrinol 19:1687-1696
23. van Exel E, Gussekloo J, Houx P, de Craen AJM, Macfarlane PW, Bootsma-van der Wiel A, Blauw GJ, Westendorp RGJ (2002) Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study. Atherosclerosis 165:353-359
24. van Rossum EF, Feelders RA, Van Den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW (2004a) Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med 117:158-162
25. van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, de Jong FH, van Duyn CM, Pols HA, Lamberts SW (2002) A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51:3128-3134
26. van Rossum EF, Koper JW, Van Den Beld AW, Uitterlinden AG, Arp P, Ester W, Janssen JA, Brinkmann AO, de Jong FH, Grobbee DE, Pols HA, Lamberts SW (2003) Identification of the BclI polymorphism in the glucocorticoid receptor gene: Association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 59:585-592
27. van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarre-van de Waal HA, Kemper HC, Lamberts SW (2004b) The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J Clin Endocrinol Metab 89:4004-4009
28. Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, Knook DL, Meinders AE, Westendorp RG (1997) Total cholesterol and risk of mortality in the oldest old. Lancet 350:1119-1123
29. Weverling-Rijnsburger AW, Jonkers IJ, van Exel E, Gussekloo J, Westendorp RG (2003) High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age. Arch Intern Med 163:1549-1554