Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 1, 2015, Pages 166-171

  Li, Wenyan ^a,b,c   Wu, Jingfang ^a   Yang, Jianming ^d   Sun, Shan ^a,e   Chai, Renjie ^f   Chen, Zheng Yi ^b,c   Li, Huawei ^a,e  

^a FUDAN UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^d ANHUI MEDICAL UNIVERSITY   (China)

^e EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY   (China)

^f SOUTHEAST UNIVERSITY   (China)

Author keywords

Hair cells; Inner ear; Notch1; Proliferation; catenin

Indexed keywords

BETA CATENIN; CYCLIN D1; G PROTEIN COUPLED RECEPTOR; NOTCH RECEPTOR; TRANSCRIPTION FACTOR SOX2; WNT PROTEIN; LGR5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ARTICLE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL REGENERATION; CELL TRANSDIFFERENTIATION; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; HAIR CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MITOSIS; MOUSE; NEUROEPITHELIUM; NEWBORN; NONHUMAN; STEM CELL; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINEAGE; CYTOLOGY; LABYRINTH SUPPORTING CELLS; METABOLISM;

MAMMALIA;

ANIMALS; CELL LINEAGE; CELL PROLIFERATION; HAIR CELLS, AUDITORY; LABYRINTH SUPPORTING CELLS; MICE; MITOSIS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NOTCH; SOXB1 TRANSCRIPTION FACTORS; WNT SIGNALING PATHWAY;

EID: 84920368099     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415901112     Document Type: Article

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