Autoantibody signature for the serologic detection of ovarian cancer

Journal of Proteome Research

Volumn 14, Issue 1, 2015, Pages 578-586

  Anderson, Karen S ^a   Cramer, Daniel W ^b   Sibani, Sahar ^c   Wallstrom, Garrick ^a   Wong, Jessica ^d   Park, Jin ^a   Qiu, Ji ^a   Vitonis, Allison ^b   Labaer, Joshua ^a  

^a Arizona State University   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

autoantibodies; biomarker; Ovarian cancer; protein microarrays; proteomics

Indexed keywords

ALPHA FETOPROTEIN; AUTOANTIBODY; BIOLOGICAL MARKER; CASEIN KINASE IALPHA; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN E; DIHYDROFOLATE REDUCTASE; LONG CHAIN FATTY ACID COENZYME A LIGASE; PROSTAGLANDIN RECEPTOR; PROTEIN P16; PROTEIN P53; SURVIVIN; IMMUNOGLOBULIN G; TUMOR MARKER;

ADULT; ANTIBODY BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN MICROARRAY; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; OVARIAN NEOPLASMS; PROCEDURES; PROTEOMICS; REGRESSION ANALYSIS;

AUTOANTIBODIES; BIOMARKERS, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOGLOBULIN G; OVARIAN NEOPLASMS; PROTEIN ARRAY ANALYSIS; PROTEOMICS; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY;

EID: 84920269097     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500908n     Document Type: Article

References (48)

1. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Thun, M. J. Cancer statistics, 2009 CA-Cancer J. Clin. 2009, 59, 225-49
2. Badgwell, D.; Bast, R. C., Jr. Early detection of ovarian cancer Dis. Markers 2007, 23, 397-410
3. Bast, R. C., Jr.; Klug, T. L.; St John, E.; Jenison, E.; Niloff, J. M.; Lazarus, H.; Berkowitz, R. S.; Leavitt, T.; Griffiths, C. T.; Parker, L.; Zurawski, V. R., Jr.; Knapp, R. C. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer N. Engl. J. Med. 1983, 309, 883-7
4. Jacobs, I.; Bast, R. C., Jr. The CA 125 tumour-associated antigen: a review of the literature Hum. Reprod. 1989, 4, 1-12
5. Menon, U.; Gentry-Maharaj, A.; Hallett, R.; Ryan, A.; Burnell, M.; Sharma, A.; Lewis, S.; Davies, S.; Philpott, S.; Lopes, A.; Godfrey, K.; Oram, D.; Herod, J.; Williamson, K.; Seif, M. W.; Scott, I.; Mould, T.; Woolas, R.; Murdoch, J.; Dobbs, S.; Amso, N. N.; Leeson, S.; Cruickshank, D.; McGuire, A.; Campbell, S.; Fallowfield, L.; Singh, N.; Dawnay, A.; Skates, S. J.; Parmar, M.; Jacobs, I. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Lancet Oncol. 2009, 10, 327-40
6. Cramer, D. W.; Bast, R. C., Jr.; Berg, C. D.; Diamandis, E. P.; Godwin, A. K.; Hartge, P.; Lokshin, A. E.; Lu, K. H.; McIntosh, M. W.; Mor, G.; Patriotis, C.; Pinsky, P. F.; Thornquist, M. D.; Scholler, N.; Skates, S. J.; Sluss, P. M.; Srivastava, S.; Ward, D. C.; Zhang, Z.; Zhu, C. S.; Urban, N. Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens Cancer Prev. Res. 2011, 4, 365-74
7. Moore, R. G.; McMeekin, D. S.; Brown, A. K.; DiSilvestro, P.; Miller, M. C.; Allard, W. J.; Gajewski, W.; Kurman, R.; Bast, R. C., Jr.; Skates, S. J. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass Gynecol. Oncol. 2009, 112, 40-6
8. Yurkovetsky, Z.; Skates, S.; Lomakin, A.; Nolen, B.; Pulsipher, T.; Modugno, F.; Marks, J.; Godwin, A.; Gorelik, E.; Jacobs, I.; Menon, U.; Lu, K.; Badgwell, D.; Bast, R. C., Jr.; Lokshin, A. E. Development of a multimarker assay for early detection of ovarian cancer J. Clin. Oncol. 2010, 28, 2159-66
9. Anderson, K. S.; LaBaer, J. The sentinel within: exploiting the immune system for cancer biomarkers J. Proteome Res. 2005, 4, 1123-33
10. Hudson, M. E.; Pozdnyakova, I.; Haines, K.; Mor, G.; Snyder, M. Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 17494-9
11. Chatterjee, M.; Mohapatra, S.; Ionan, A.; Bawa, G.; Ali-Fehmi, R.; Wang, X.; Nowak, J.; Ye, B.; Nahhas, F. A.; Lu, K.; Witkin, S. S.; Fishman, D.; Munkarah, A.; Morris, R.; Levin, N. K.; Shirley, N. N.; Tromp, G.; Abrams, J.; Draghici, S.; Tainsky, M. A. Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays Cancer Res. 2006, 66, 1181-90
12. Gagnon, A.; Kim, J. H.; Schorge, J. O.; Ye, B.; Liu, B.; Hasselblatt, K.; Welch, W. R.; Bandera, C. A.; Mok, S. C. Use of a combination of approaches to identify and validate relevant tumor-associated antigens and their corresponding autoantibodies in ovarian cancer patients Clin. Cancer Res. 2008, 14, 764-71
13. Anderson, K. S.; Sibani, S.; Wallstrom, G.; Qiu, J.; Mendoza, E. A.; Raphael, J.; Hainsworth, E.; Montor, W. R.; Wong, J.; Park, J. G.; Lokko, N.; Logvinenko, T.; Ramachandran, N.; Godwin, A. K.; Marks, J.; Engstrom, P.; Labaer, J. Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer J. Proteome Res. 2011, 10, 85-96
14. Goodell, V.; Salazar, L. G.; Urban, N.; Drescher, C. W.; Gray, H.; Swensen, R. E.; McIntosh, M. W.; Disis, M. L. Antibody immunity to the p53 oncogenic protein is a prognostic indicator in ovarian cancer J. Clin. Oncol. 2006, 24, 762-8
15. Tsai-Turton, M.; Santillan, A.; Lu, D.; Bristow, R. E.; Chan, K. C.; Shih, I.-M.; Roden, R. B. p53 autoantibodies, cytokine levels and ovarian carcinogenesis Gynecol. Oncol. 2009, 114, 12-7
16. Anderson, K. S.; Wong, J.; Vitonis, A.; Crum, C. P.; Sluss, P. M.; Labaer, J.; Cramer, D. p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer Cancer Epidemiol., Biomarkers Prev. 2010, 19, 859-68
17. Ramachandran, N.; Raphael, J. V.; Hainsworth, E.; Demirkan, G.; Fuentes, M. G.; Rolfs, A.; Hu, Y.; LaBaer, J. Next-generation high-density self-assembling functional protein arrays Nat. Methods 2008, 5, 535-8
18. Ramachandran, N.; Anderson, K. S.; Raphael, J. V.; Hainsworth, E.; Sibani, S.; Montor, W. R.; Pacek, M.; Wong, J.; Eljanne, M.; Sanda, M. G.; Hu, Y.; Logvinenko, T.; Labaer, J. Tracking humoral responses using self assembling protein microarrays Proteomics: Clin. Appl. 2008, 2, 1518-27
19. Anderson, K. S.; Ramachandran, N.; Wong, J.; Raphael, J. V.; Hainsworth, E.; Demirkan, G.; Cramer, D.; Aronzon, D.; Hodi, F. S.; Harris, L.; Logvinenko, T.; LaBaer, J. Application of protein microarrays for multiplexed detection of antibodies to tumor antigens in breast cancer J. Proteome Res. 2008, 7, 1490-9
20. Ramachandran, N.; KS, A.; Raphael, J.; Hainsworth, E.; Sibani, S.; Montor, W.; Pacek, M.; Wong, J.; Eljanne, M.; Sanda, M.; Hu, Y.; Logvinenko, T.; LaBaer, J. Tracking humoral responses using self assembling protein microarrays Proteomics: Clin. Appl. 2008, 2, 1518-1527
21. Anderson, K. S.; Sibani, S.; Wallstrom, G.; Qiu, J.; Mendoza, E. A.; Raphael, J.; Hainsworth, E.; Montor, W. R.; Wong, J.; Park, J. G.; Lokko, N.; Logvinenko, T.; Ramachandran, N.; Godwin, A. K.; Marks, J.; Engstrom, P.; Labaer, J. Protein microarray signature of autoantibody biomarkers for the early detection of breast cancer J. Proteome Res. 2011, 10, 85-96
22. Wong, J.; Sibani, S.; Lokko, N. N.; LaBaer, J.; Anderson, K. S. Rapid detection of antibodies in sera using multiplexed self-assembling bead arrays J. Immunol. Methods 2009, 350, 171-82
23. Koenker, R. W. Quantile Regression; Cambridge University Press: New York, 2005.
24. Efron, B. Bootstrap methods: another look at the jackknife Ann. Stat. 1979, 7, 1-26
25. Storey, J. A direct approach to false discovery rates J. R. Stat. Soc. B 2002, 64, 479-498
26. Witt, A. E.; Hines, L. M.; Collins, N. L.; Hu, Y.; Gunawardane, R. N.; Moreira, D.; Raphael, J.; Jepson, D.; Koundinya, M.; Rolfs, A.; Taron, B.; Isakoff, S. J.; Brugge, J. S.; LaBaer, J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer J. Proteome Res. 2006, 5, 599-610
27. Anderson, K. S.; Wong, J.; Vitonis, A.; Crum, C. P.; Sluss, P. M.; Labaer, J.; Cramer, D. p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer Cancer Epidemiol., Biomarkers Prev. 2010, 19, 859-68
28. Keightley, M. C.; Sales, K. J.; Jabbour, H. N. PGF2alpha-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer BMC Cancer 2010, 10, 488
29. Sales, K. J.; Maudsley, S.; Jabbour, H. N. Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3′,5′-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase 1/2 signaling pathways Mol. Endocrinol. 2004, 18, 1533-45
30. Saito, O.; Guan, Y.; Qi, Z.; Davis, L. S.; Komhoff, M.; Sugimoto, Y.; Narumiya, S.; Breyer, R. M.; Breyer, M. D. Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract Am. J. Physiol.: Renal Physiol. 2003, 284, F1164-70
31. Romanuik, T. L.; Wang, G.; Morozova, O.; Delaney, A.; Marra, M. A.; Sadar, M. D. LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer BMC Med. Genomics 2010, 3, 43
32. Wu, C. W.; Kao, H. L.; Li, A. F.; Chi, C. W.; Lin, W. C. Protein tyrosine-phosphatase expression profiling in gastric cancer tissues Cancer Lett. 2006, 242, 95-103
33. Junnila, S.; Kokkola, A.; Karjalainen-Lindsberg, M. L.; Puolakkainen, P.; Monni, O. Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines BMC Cancer 2010, 10, 73
34. Zhang, X. Q.; Kondrikov, D.; Yuan, T. C.; Lin, F. F.; Hansen, J.; Lin, M. F. Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells Oncogene 2003, 22, 6704-16
35. Lucci, M. A.; Orlandi, R.; Triulzi, T.; Tagliabue, E.; Balsari, A.; Villa-Moruzzi, E. Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors Cell Oncol. 2010, 32, 361-72
36. Abali, E. E.; Skacel, N. E.; Celikkaya, H.; Hsieh, Y. C. Regulation of human dihydrofolate reductase activity and expression Vitam. Horm. 2008, 79, 267-92
37. Trent, J. M.; Buick, R. N.; Olson, S.; Horns, R. C., Jr.; Schimke, R. T. Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma J. Clin. Oncol. 1984, 2, 8-15
38. Levina, V. V.; Nolen, B.; Su, Y.; Godwin, A. K.; Fishman, D.; Liu, J.; Mor, G.; Maxwell, L. G.; Herberman, R. B.; Szczepanski, M. J.; Szajnik, M. E.; Gorelik, E.; Lokshin, A. E. Biological significance of prolactin in gynecologic cancers Cancer Res. 2009, 69, 5226-33
39. Blotta, S.; Tassone, P.; Prabhala, R. H.; Tagliaferri, P.; Cervi, D.; Amin, S.; Jakubikova, J.; Tai, Y. T.; Podar, K.; Mitsiades, C. S.; Zullo, A.; Franco, B.; Anderson, K. C.; Munshi, N. C. Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance Blood 2009, 114, 3276-84
40. Piura, B.; Piura, E. Autoantibodies to tumor-associated antigens in epithelial ovarian carcinoma J. Oncol. 2009, 2009, 581939
41. Philip, R.; Murthy, S.; Krakover, J.; Sinnathamby, G.; Zerfass, J.; Keller, L.; Philip, M. Shared immunoproteome for ovarian cancer diagnostics and immunotherapy: potential theranostic approach to cancer J. Proteome Res. 2007, 6, 2509-17
42. Ehrlich, J. R.; Tang, L.; Caiazzo, R. J., Jr.; Cramer, D. W.; Ng, S. K.; Ng, S. W.; Liu, B. C. The "reverse capture" autoantibody microarray: an innovative approach to profiling the autoantibody response to tissue-derived native antigens Methods Mol. Biol. 2008, 441, 175-92
43. Wandall, H. H.; Blixt, O.; Tarp, M. A.; Pedersen, J. W.; Bennett, E. P.; Mandel, U.; Ragupathi, G.; Livingston, P. O.; Hollingsworth, M. A.; Taylor-Papadimitriou, J.; Burchell, J.; Clausen, H. Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes Cancer Res. 2010, 70, 1306-13
44. Gunawardana, C. G.; Memari, N.; Diamandis, E. P. Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays Clin. Biochem. 2009, 42, 426-9
45. Gnjatic, S.; Ritter, E.; Buchler, M. W.; Giese, N. A.; Brors, B.; Frei, C.; Murray, A.; Halama, N.; Zornig, I.; Chen, Y. T.; Andrews, C.; Ritter, G.; Old, L. J.; Odunsi, K.; Jager, D. Seromic profiling of ovarian and pancreatic cancer Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 5088-93
46. Taylor, D. D.; Gercel-Taylor, C.; Parker, L. P. Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer Gynecol. Oncol. 2009, 115, 112-20
47. Tang, L.; Yang, J.; Ng, S. K.; Rodriguez, N.; Choi, P. W.; Vitonis, A.; Wang, K.; McLachlan, G. J.; Caiazzo, R. J., Jr.; Liu, B. C.; Welch, W. R.; Cramer, D. W.; Berkowitz, R. S.; Ng, S. W. Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer Eur. J. Cancer 2010, 46, 170-9
48. Li, L.; Wang, K.; Dai, L.; Wang, P.; Peng, X. X.; Zhang, J. Y. Detection of autoantibodies to multiple tumor-associated antigens in the immunodiagnosis of ovarian cancer Mol. Med. Rep. 2008, 1, 589-94