Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

The Lancet Oncology

Volumn 10, Issue 4, 2009, Pages 327-340

  Menon, Usha ^a   Gentry Maharaj, Aleksandra ^a   Hallett, Rachel ^a   Ryan, Andy ^a   Burnell, Matthew ^a   Sharma, Aarti ^a   Lewis, Sara ^a   Davies, Susan ^a   Philpott, Susan ^a   Lopes, Alberto ^b   Godfrey, Keith ^b   Oram, David ^c   Herod, Jonathan ^d   Williamson, Karin ^e   Seif, Mourad W ^f   Scott, Ian ^g   Mould, Tim ^h   Woolas, Robert ⁱ   Murdoch, John ^j   Dobbs, Stephen ^k   Amso, Nazar N ^l   Leeson, Simon ^m   Cruickshank, Derek ⁿ   Mcguire, Alistair ^o   Campbell, Stuart ^p   Fallowfield, Lesley ^q   Singh, Naveena ^r   Dawnay, Anne ^s   Skates, Steven J ^t   Parmar, Mahesh ^u   Jacobs, Ian ^a   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^d LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^e NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^f ST MARY S HOSPITAL   (United Kingdom)

^g DERBY CITY GENERAL HOSPITAL   (United Kingdom)

^h ROYAL FREE HOSPITAL   (United Kingdom)

ⁱ ST MARY S HOSPITAL   (United Kingdom)

^j ST MICHAEL'S HOSPITAL   (United Kingdom)

^k BELFAST CITY HOSPITAL   (United Kingdom)

^l CARDIFF UNIVERSITY   (United Kingdom)

^m Llandudno LL30 1LB   (United Kingdom)

ⁿ JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^o LONDON SCHOOL OF ECONOMICS   (United Kingdom)

^p Create Health Clinic   (United Kingdom)

^q UNIVERSITY OF SUSSEX   (United Kingdom)

^r QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^s UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^t HARVARD MEDICAL SCHOOL   (United States)

^u MEDICAL RESEARCH COUNCIL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN;

ADOLESCENT; ADULT; ANTIGEN DETECTION; ARTICLE; CANCER MORTALITY; CANCER SCREENING; CANCER STAGING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LAPAROTOMY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OVARY CANCER; POSTMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; TRANSVAGINAL ECHOGRAPHY; UNITED KINGDOM; UTERINE TUBE TUMOR;

AGED; CA-125 ANTIGEN; EARLY DETECTION OF CANCER; FALSE POSITIVE REACTIONS; FEMALE; GREAT BRITAIN; HUMANS; MASS SCREENING; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; OVARIAN NEOPLASMS; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROGNOSIS; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 63149087256     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(09)70026-9     Document Type: Article

References (36)

1. Office for National Statistics. Mortality statistics cause: review of the Registrar General on deaths by cause, sex and age, England and Wales (2005) 275 Series DH2 32.
2. Berrino F., De Angelis R., Sant M., et al. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol 8 (2007) 773-783
3. Stearns A.T., Hole D., George W.D., and Kingsmore D.B. Comparison of breast cancer mortality rates with those of ovarian and colorectal carcinoma. Br J Surg 94 (2007) 957-965
4. Engel J., Eckel R., Schubert-Fritschle G., et al. Moderate progress for ovarian cancer in the last 20 years: prolongation of survival, but no improvement in the cure rate. Eur J Cancer 38 (2002) 2435-2445
5. CRUK. UK Ovarian cancer survival statistics. http://info.cancerresearchuk.org/cancerstats/types/ovary/survival/ (accessed Nov 15, 2008).
6. Jacobs I., Stabile I., Bridges J., et al. Multimodal approach to screening for ovarian cancer. Lancet 1 (1988) 268-271
7. Campbell S., Bhan V., Royston P., Whitehead M.I., and Collins W.P. Transabdominal ultrasound screening for early ovarian cancer. BMJ 299 (1989) 1363-1367
8. Jacobs I.J., Skates S.J., MacDonald N., et al. Screening for ovarian cancer: a pilot randomised controlled trial. Lancet 353 (1999) 1207-1210
9. van Nagell Jr. J.R., DePriest P.D., Ueland F.R., et al. Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened. Cancer 109 (2007) 1887-1896
10. DePriest P.D., and van Nagell Jr. J.R. Transvaginal ultrasound screening for ovarian cancer. Clin Obstet Gynecol 35 (1992) 40-44
11. DePriest P.D., Shenson D., Fried A., et al. A morphology index based on sonographic findings in ovarian cancer. Gynecol Oncol 51 (1993) 7-11
12. Menon U., Talaat A., Jeyarajah A.R., et al. Ultrasound assessment of ovarian cancer risk in postmenopausal women with CA125 elevation. Br J Cancer 80 (1999) 1644-1647
13. Timmerman D., Valentin L., Bourne T.H., Collins W.P., Verrelst H., and Vergote I. Terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group. Ultrasound Obstet Gynecol 16 (2000) 500-505
14. Skates S.J., Pauler D., and Jacobs I.J. Screening based on the risk of cancer calculation from Bayesian hierarchical change point and mixture models of longitudinal markers. J Am Stat Assoc 96 (2001) 429-439
15. Skates S.J., Menon U., MacDonald N., et al. Calculation of the risk of ovarian cancer from serial CA-125 values for preclinical detection in postmenopausal women. J Clin Oncol 21 10 suppl (2003) 206s-210s
16. Menon U., Gentry-Maharaj A., Ryan A., et al. Recruitment to multicentre trials-lessons from UKCTOCS: descriptive study. BMJ 337 (2008) 1283-1286
17. Menon U., Skates S.J., Lewis S., et al. Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer. J Clin Oncol 23 (2005) 7919-7926
18. Rufford B., Menon U., and Jacobs I. Screening for familial ovarian cancer. In: Morrison P.J., Hodgson S.V., and Haites N.E. (Eds). Familial breast and ovarian cancer-genetics, screening and management (2002), Cambridge University Press, Cambridge 220-233
19. DePriest P.D., Varner E., Powell J., et al. The efficacy of a sonographic morphology index in identifying ovarian cancer: a multi-institutional investigation. Gynecol Oncol 55 (1994) 174-178
20. Senn S.J. Covariate imbalance and random allocation in clinical trials. Stat Med 8 (1989) 467-475
21. Senn S. Testing for baseline balance in clinical trials. Stat Med 13 (1994) 1715-1726
22. Kobayashi H., Yamada Y., Sado T., et al. A randomized study of screening for ovarian cancer: a multicenter study in Japan. Int J Gynecol Cancer 18 (2008) 414-420
23. Buys S.S., Partridge E., Greene M.H., et al. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. Am J Obstet Gynecol 193 (2005) 1630-1639
24. Skirnisdottir I., Garmo H., Wilander E., and Holmberg L. Borderline ovarian tumors in Sweden 1960-2005: trends in incidence and age at diagnosis compared to ovarian cancer. Int J Cancer 123 (2008) 1897-1901
25. Sherman M.E., Mink P.J., Curtis R., et al. Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysis. Cancer 100 (2004) 1045-1052
26. Biesheuvel C., Barratt A., Howard K., Houssami N., and Irwig L. Effects of study methods and biases on estimates of invasive breast cancer overdetection with mammography screening: a systematic review. Lancet Oncol 8 (2007) 1129-1138
27. Telesca D., Etzioni R., and Gulati R. Estimating lead time and overdiagnosis associated with PSA screening from prostate cancer incidence trends. Biometrics 64 (2008) 10-19
28. Reich J.M. A critical appraisal of overdiagnosis: estimates of its magnitude and implications for lung cancer screening. Thorax 63 (2008) 377-383
29. Valentin L., Ameye L., Testa A., et al. Ultrasound characteristics of different types of adnexal malignancies. Gynecol Oncol 102 (2006) 41-48
30. Timmerman D., Verrelst H., Bourne T.H., et al. Artificial neural network models for the preoperative discrimination between malignant and benign adnexal masses. Ultrasound Obstet Gynecol 13 (1999) 17-25
31. Valentin L. Pattern recognition of pelvic masses by gray-scale ultrasound imaging: the contribution of Doppler ultrasound. Ultrasound Obstet Gynecol 14 (1999) 338-347
32. Dorum A., Blom G.P., Ekerhovd E., and Granberg S. Prevalence and histologic diagnosis of adnexal cysts in postmenopausal women: an autopsy study. Am J Obstet Gynecol 192 (2005) 48-54
33. Valentin L. Use of morphology to characterize and manage common adnexal masses. Best Pract Res Clin Obstet Gynaecol 18 (2004) 71-89
34. In: Ries L., Eisner M.P., and Kosary C.L. (Eds). SEER cancer statistics review, 1975-2002 (2005), National Cancer Institute, Bethesda, MD, USA
35. Ueland F.R., DePriest P.D., Pavlik E.J., Kryscio R.J., and van Nagell Jr. J.R. Preoperative differentiation of malignant from benign ovarian tumors: the efficacy of morphology indexing and Doppler flow sonography. Gynecol Oncol 91 (2003) 46-50
36. Bailey C.L., Ueland F.R., Land G.L., et al. The malignant potential of small cystic ovarian tumors in women over 50 years of age. Gynecol Oncol 69 (1998) 3-7