Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 178-190

  Ma, Liang ^a   Pei, Heying ^a   Lei, Lei ^a   He, Linhong ^a   Chen, Jinying ^a   Liang, Xiaolin ^a   Peng, Aihua ^a   Ye, Haoyu ^a   Xiang, Mingli ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

5 Benzylidenethiazolidine 2,4 dione; Inducible nitric oxide synthase; Inflammation; Nitric oxide; Paw edema

Indexed keywords

5 BENZYLIDENETHIAZOLIDINE 2,4 DIONE DERIVATIVE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5-BENZYLIDENE THIAZOLIDINE-2,4-DIONE; BENZYLIDENE DERIVATIVE; ENZYME INHIBITOR;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC50; KNOEVENAGEL CONDENSATION; MALE; MOUSE; NONHUMAN; PAW EDEMA; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; EDEMA; INFLAMMATION; INSTITUTE FOR CANCER RESEARCH MOUSE; LEWIS RAT; METABOLISM; RAT; SYNTHESIS;

ANIMALS; BENZYLIDENE COMPOUNDS; CARRAGEENAN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENZYME INHIBITORS; FEMALE; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, INBRED LEW; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 84920119002     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.036     Document Type: Article

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