High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: Human African trypanosomiasis, leishmaniasis, and chagas disease

Journal of Biomolecular Screening

Volumn 20, Issue 1, 2015, Pages 82-91

  Annang, F ^a   Perez Moreno G ^b   Garcia Hernandez R ^b   Cordon Obras, C ^b   Martin J ^a   Tormo, J R ^a   Rodriguez L ^a   De Pedro, N ^a   Gomez Perez V ^b   Valente, M ^b   Reyes, F ^a   Genilloud, O ^a   Vicente, F ^a   Castanys, S ^b   Ruiz Perez L M ^b   Navarro, M ^b   Gamarro, F ^b   Gonzalez Pacanowska D ^b  

^a Health Sciences Technology Park   (Spain)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Chagas disease; high throughput screening; human African trypanosomiasis; kinetoplastids; leishmaniasis; microbial extracts; natural products; tropical diseases

Indexed keywords

BAFILOMYCIN B1; CHROMOMYCIN A3; DACTINOMYCIN; ECHINOMYCIN; HYGROLIDIN; NATURAL PRODUCT; NONACTIN; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; BIOLOGICAL PRODUCT;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CHAGAS DISEASE; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; KINETOPLASTIDA; LEISHMANIA DONOVANI; LEISHMANIASIS; LIQUID CHROMATOGRAPHY; NEGLECTED DISEASE; NONHUMAN; PILOT STUDY; TANDEM MASS SPECTROMETRY; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI; VALIDATION STUDY; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; HUMAN; IC50; LEISHMANIA; NEGLECTED DISEASES; PROCEDURES; STANDARDS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

KINETOPLASTIDA;

ANIMALS; ANTIPROTOZOAL AGENTS; BIOLOGICAL PRODUCTS; CHAGAS DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA; LEISHMANIASIS; NEGLECTED DISEASES; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS, AFRICAN;

EID: 84920098309     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114555846     Document Type: Article

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