Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex

Environmental Toxicology and Pharmacology

Volumn 39, Issue 1, 2015, Pages 157-166

  Yang, Tian yao ^a   Xu, Zhao fa ^a   Liu, Wei ^a   Xu, Bin ^a   Deng, Yu ^a   Li, Yue hui ^a   Feng, Shu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

LA; Methylmercury; Neurotoxicity; Oxidative stress

Indexed keywords

AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMIC ACID; MESSENGER RNA; PROTEIN GLT 1; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; UNCLASSIFIED DRUG; EXCITATORY AMINO ACID TRANSPORTER 2; MALONALDEHYDE; METHYLMERCURY DERIVATIVE; NEUROPROTECTIVE AGENT; POLLUTANT; SLC1A2 PROTEIN, RAT; SLC1A3 PROTEIN, RAT;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; ANIMAL; DRUG EFFECTS; METABOLISM; NEUROTOXICITY SYNDROMES; PATHOLOGY; PHARMACOKINETICS; POLLUTANT; TOXICITY; WISTAR RAT;

RATTUS;

ANIMALS; CEREBRAL CORTEX; ENVIRONMENTAL POLLUTANTS; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GLUTAMIC ACID; MALE; MALONDIALDEHYDE; METHYLMERCURY COMPOUNDS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; THIOCTIC ACID;

EID: 84920075514     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2014.11.020     Document Type: Article

References (29)

1. Allen J.W., Mutkus L.A., Aschner M. Methylmercury-mediated inhibition of 3H-d-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase. Brain Res. 2001, 902:92-100.
2. Alturfan A.A., Tozan-Beceren A., Sehirli A.O., Demiralp E., Sener G., Omurtag G.Z. Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Mol. Biol. Rep. 2012, 39:4589-4596.
3. Aschner M., Syversen T., Souza D.O., Rocha J.B., Farina M. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz. J. Med. Biol. Res. 2007, 40:285-291.
4. Bertolotto F., Massone A. Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R. D. 2012, 12:29-34.
5. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52:302-310.
6. 2+) is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis. Chem. Biol. Interact. 2011, 190:16-27.
7. Ceccatelli S., Daré E., Moors M. Methylmercury-induced neurotoxicity and apoptosis. Chem. Biol. Interact. 2010, 188:301-308.
8. Cheng W.W., Lin Z.Q., Wei B.F., Zeng Q., Han B., Wei C.X., Fan X.J., Hu C.L., Liu L.H., Huang J.H., Yang X., Xi Z.G. Single-walled carbon nanotube induction of rat aortic endothelial cell apoptosis: reactive oxygen species are involved in the mitochondrial pathway. Int. J. Biochem. Cell Biol. 2011, 43:564-572.
9. Clarkson T.W., Magos L., Myers G.J. The toxicology of mercury-current exposures and clinical manifestations. N. Engl. J. Med. 2003, 349:1731-1737.
10. Deng Y., Xu Z., Xu B., Tian Y., Xin X., Deng X., Gao J. The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats. Brain Res. 2009, 1289:106-117.
11. Farina M., Campos F., Vendrell I., Berenguer J., Barzi M., Pons S., Suñol C. Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol. Sci. 2009, 112:416-426.
12. Farina M., Aschner M., Rocha J.B. Oxidative stress in MeHg-induced neurotoxicity. Toxicol. Appl. Pharmacol. 2011, 256:405-417.
13. Ferreira P.M., Militão G.C., Freitas R.M. Lipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampus. Neurosci. Lett. 2009, 464:131-134.
14. Franco J.L., Posser T., Dunkley P.R., Dickson P.W., Mattos J.J., Martins R., Bainy A.C., Marques M.R., Dafre A.L., Farina M. Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase. Free Radic. Biol. Med. 2009, 47:449-457.
15. Grandjean P., Satoh H., Murata K., Eto K. Adverse effects of methylmercury: environmental health research implications. Environ. Health Perspect. 2010, 118:1137-1145.
16. Guerguerian A.M., Brambrink A.M., Traystman R.J., Huganir R.L., Martin L.J. Altered expression and phosphorylation of N-methyl-d-aspartate receptors in piglet striatum after hypoxia-ischemia. Brain Res. Mol. Brain Res. 2002, 104:66-80.
17. Kim Y.S., Podder B., Song H.Y. Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway. Biol. Pharm. Bull. 2013, 36:802-811.
18. Lipton S.A. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 2006, 5:160-170.
19. Liu W., Xu Z., Deng Y., Xu B., Yang H., Wei Y., Feng S. Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols. Environ. Toxicol. 2014, 29:269-283.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
21. Márquez J., Tosina M., de, la, Rosa V., Segura J.A., Alonso F.J., Matés J.M., Campos-Sandoval J.A. New insights into brain glutaminases: beyond their role on glutamatergic transmission. Neurochem. Int. 2009, 55:64-70.
22. Mei Y.Q., Song S.Q. Response to temperature stress of reactive oxygen species scavenging enzymes in the cross-tolerance of barley seed germination. J. Zhejiang. Univ. Sci. B 2010, 11:965-972.
23. Mozziconacci O., Williams T.D., Schöneich C. Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly. Chem. Res. Toxicol. 2012, 25:1842-1861.
24. Roy S.S., Chakraborty P., Bhattacharya S. Intervention in cyclophosphamide induced oxidative stress and DNA damage by a flavonyl-thiazolidinedione based organoselenocyanate and evaluation of its efficacy during adjuvant therapy in tumor bearing mice. Eur. J. Med. Chem. 2014, 73:195-209.
25. Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim. Biophys. Acta 2009, 1790:1149-1160.
26. Stockwell P.B., Corns W.T. The role of atomic fluorescence spectrometry in the automatic environmental monitoring of trace element analysis. J. Autom. Chem. 1993, 15:79-84.
27. Szelg M., Mikulski D., Molski M. Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites. J. Mol. Model. 2012, 18:2907-2916.
28. Wang R., Wong M.H., Wang W.X. Coupling of methylmercury uptake with respiration and water pumping in freshwater tilapia Oreochromis niloticus. Environ. Toxicol. Chem. 2011, 30:2142-2147.
29. Yin Z., Lee E., Ni M., Jiang H., Milatovic D., Rongzhu L., Farina M., Rocha J.B., Aschner M. Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology 2011, 32:291-299.