Building a robust 21st century chemical testing program at the U.S. Environmental protection agency: Recommendations for strengthening scientific engagement

Environmental Health Perspectives

Volumn 123, Issue 1, 2015, Pages 1-5

  McPartland, Jennifer ^a   Dantzker, Heather C ^b   Portier, Christopher J ^a  

^a ENVIRONMENTAL DEFENSE FUND   (United States)

^b Dantzker Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLLUTANT;

COOPERATION; GOVERNMENT; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; ORGANIZATION; POLLUTANT; PROCEDURES; TOXICITY; TOXICITY TESTING; UNITED STATES;

COOPERATIVE BEHAVIOR; ENVIRONMENTAL POLLUTANTS; HIGH-THROUGHPUT SCREENING ASSAYS; IN VITRO TECHNIQUES; NATIONAL ACADEMY OF SCIENCES (U.S.); TOXICITY TESTS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 84920073814     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408601     Document Type: Note

References (30)

1. Bucher JR. 2013. Regulatory forum opinion piece: Tox21 and toxicologic pathology. Toxicol Pathol 41:125-127.
2. CBCRP (California Breast Cancer Research Program). 2014. Building on National Initiatives for New Chemicals Screening. Available: http://cbcrp.org.184.seekdotnet.com/research/PageGrant.asp?grant_id=13094 [accessed 10 December 2014].
3. Denison R. 2009. Ten essential elements in TSCA reform. Environ Law Rep 39:10020-10028. Available: http://www.edf.org/sites/default/files/9279_Denison_10_Elements_TSCA_Reform_0.pdf [accessed 3 December 2014].
4. Judson R, Richard A, Dix DJ, Houck K, Martin M, Kavlock R, et al. 2009. The toxicity landscape for environmental chemicals. Environ Health Perspect 117:685-695; doi:10.1289/ehp.0800168.
5. Landrigan PJ, Goldman LR. 2014. Chemical safety, health care costs and the Affordable Care Act. Am J Ind Med 57:1-3.
6. NRC (National Research Council). 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC:National Academies Press. Available: http://www.nap.edu/openbook. php?record_id=11970 [accessed 3 December 2014].
7. NRC (National Research Council). 2008. Public Participation in Environmental Assessment and Decision Making (Dietz T, Stern PC, eds). Washington, DC:National Academies Press. Available: http://www.nap.edu/openbook. php?record_id=12434 [accessed 3 December 2014].
8. NTP (National Toxicology Program). 2004a. A National Toxicology Program for the 21st Century: A Roadmap for the Future. Research Triangle Park, NC:NTP/National Institute of Environmental Health Sciences. Available: http://ntp.niehs.nih.gov/ntp/about_ntp/ntpvision/ntproadmap_508.pdf [accessed 3 December 2014].
9. NTP (National Toxicology Program). 2004b. Toxicology in the 21st Century: The Role of the National Toxicology Program. Research Triangle Park, NC:NTP/National Institute of Environmental Health Sciences. Available: http://ntp.niehs.nih.gov/ntp?main_pages/ntpvision.pdf [accessed 3 December 2014].
10. Parham F, Wise A, Axelrad DA, Guyton KZ, Portier C, Zeise L, et al. 2012. Adverse effects in risk assessment: modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans. Environ Res 116:74-84.
11. Portier C. 2001. Chipping away at environmental health risk assessment. Risk Policy Rep 8:37-38.
12. Portier C. 2009. Toxicological decision-making on hazards and risks—status quo and way forward: 4.1 current concepts and schemes of science-driven toxicological decision-making—an overview. Hum Exp Toxicol 28:123-125.
13. Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, et al. 2011. Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environ Health Perspect 119:364-370; doi:10.1289/ehp.1002476.
14. Sirenko O, Hesley J, Rusyn I, Cromwell EF. 2014. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay Drug Dev Technol 12:43-54.
15. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. 2012. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect 120:779-789; doi:10.1289/ehp.1104597.
16. Tice RR, Austin CP, Kavlock RJ, Bucher JR. 2013. Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect 121:756-765; doi:10.1289/ehp.1205784.
17. U.S. EPA (U.S. Environmental Protection Agency). 2012. EPA Awards Almost $11 Million to Advance Chemical Safety Research [News Release]. Available: http://yosemite.epa.gov/opa/admpress.nsf/e51aa292bac25b0b85257359003d925f/e8758b7bd3c66d4885257a7800545bbd!OpenDocument [accessed 3 December 2014].
18. U.S. EPA (U.S. Environmental Protection Agency). 2014a. Communities of Practice. Available: http://www.epa.gov/ncct/communities_of_practice.html [accessed 3 March 2014].
19. U.S. EPA (U.S. Environmental Protection Agency). 2014b. Chemical Safety Research Partnerships. Available: http://www.epa.gov/ncct/partners.html [accessed 30 September 2014].
20. U.S. EPA (U.S. Environmental Protection Agency). 2014c. EPA Awards More Than $3 Million to Researchers Studying How Chemical Exposures May Impact Brain Development [News Release]. Available: http://yosemite.epa.gov/opa/admpress.nsf/0/5A 399B72E128AFE485257C7D005E8582 [accessed 3 December 2014].
21. U.S. EPA (U.S. Environmental Protection Agency). 2014d. EPA’s ToxCast™ Research Program. Available: http://www.epa.gov/pesticides/science?toxcast-research.html [accessed 30 September 2014].
22. U.S. EPA (U.S. Environmental Protection Agency). 2014e. Memorandum of Understanding on High Throughput Screening, Toxicity Pathway Profiling, and Biological Interpretation of Findings. Available: http://epa.gov/ncct/download_files/tox21/MOU_EPA-NTP-NCGC-FDA-Without-Signature-Page.pdf [accessed 30 September 2014].
23. U.S. EPA (U.S. Environmental Protection Agency). 2014f. Research Project Search. [Research Category: “Computational Toxicology.”] Available: http://cfpub.epa.gov/ncer_abstracts/index. cfm/fuseaction/search.welcome [accessed 30 September 2014].
24. U.S. EPA (U.S. Environmental Protection Agency). 2014g. Tox21. Available: http://www.epa.gov/ncct?Tox21?[accessed 30 September 2014].
25. U.S. EPA (U.S. Environmental Protection Agency). 2014h. ToxCast™ Chemical Data Challenges and Release. Available: http://www.epa.gov/ncct?challenges.html [accessed 30 September 2014].
26. U.S. EPA (U.S. Environmental Protection Agency). 2014i. ToxCast™ Data Analysis Summit. Available: http://www.epa.gov/ncct/toxcast/summit.html [accessed 30 September 2014].
27. U.S. EPA (U.S. Environmental Protection Agency). 2014j. TSCA Chemical Substance Inventory. Basic Information. Available: http://www.epa.gov/oppt?existingchemicals/pubs/tscainventory/basic.html [accessed 30 September 2014].
28. Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ III, Judson RS, et al. 2013. Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci 132:327-346.
29. Wise A, Parham F, Axelrad DA, Guyton KZ, Portier C, Zeise L, et al. 2012. Upstream adverse effects in risk assessment: a model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans. Environ Res 117:90-99.
30. Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller M, et al. 2008. Meeting report: Moving upstream—evaluating adverse upstream end points for improved risk assessment and decision-making. Environ Health Perspect 116:1568-1575; doi:10.1289?ehp.11516.