Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 91-102

  Vandekerckhove, Stéphanie ^a   Van Herreweghe, Sofie ^a   Willems, Jasmine ^a   Danneels, Barbara ^a   Desmet, Tom ^a   De Kock, Carmen ^b   Smith, Peter J ^b   Chibale, Kelly ^c   D'Hooghe, Matthias ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antimalarial agents; Antimicrobial agents; Pyrrolidine derivatives; Quinolines

Indexed keywords

2 METHYL 3 (2 METHYLPYRROLIDIN 1 YL)QUINOLINE; 3 (2 METHYLPYRROLIDIN 1 YL)QUINOLINE; 3 (PYRROLIDIN 1 YL)QUINOLINE; 4 (QUINOLIN 3 YLAMINO)BUTANOL; 4 (QUINOLIN 5 YLAMINO)BUTANOL; 4 (QUINOLIN 6 YLAMINO)BUTANOL; 4 (QUINOLIN 8 YLAMINO)BUTANOL; 5 (2 METHYLPYRROLIDIN 1 YL)QUINOLINE; 5 (2 METHYLQUINOLIN 3 YLAMINO) 2 METHYLPENTAN 2 OL; 5 (2 METHYLQUINOLIN 3 YLAMINO)PENTAN 2 OL; 5 (PYRROLIDIN 1 YL)QUINOLINE; 5 (QUINOLIN 3 YLAMINO)PENTAN 2 ONE; 5 (QUINOLIN 5 YLAMINO) 2 METHYLPENTAN 2 OL; 5 (QUINOLIN 5 YLAMINO)PENTAN 2 OL; 5 (QUINOLIN 5 YLAMINO)PENTAN 2 ONE; 5 (QUINOLIN 6 YLAMINO) 2 METHYLPENTAN 2 OL; 5 (QUINOLIN 6 YLAMINO)PENTAN 2 OL; 5 (QUINOLIN 6 YLAMINO)PENTAN 2 ONE; 5 (QUINOLIN 8 YLAMINO) 2 METHYLPENTAN 2 OL; 6 (2 METHYLPYRROLIDIN 1 YL)QUINOLINE; 6 (PYRROLIDIN 1 YL)QUINOLINE; 8 (2 OXOPYRROLIDIN 1 YL)QUINOLINE; AMINOQUINOLINE DERIVATIVE; AMPHOTERICIN B; ANTIFUNGAL AGENT; ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; EMETINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; BROMINATION; CANDIDA ALBICANS; CONTROLLED STUDY; DERIVATIZATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMODIUM FALCIPARUM; RHODOTORULA; RHODOTORULA BOGORIENSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; SYNTHESIS;

AMINOQUINOLINES; ANTIFUNGAL AGENTS; ANTIMALARIALS; ASPERGILLUS FLAVUS; DOSE-RESPONSE RELATIONSHIP, DRUG; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; RHODOTORULA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84919947877     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.020     Document Type: Article

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