Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline- sulfonamide as hybrid antiprotozoal agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 3080-3089

  Salahuddin, Attar ^a   Inam, Afreen ^a   Van Zyl, Robyn L ^b   Heslop, Donovan C ^b   Chen, Chien Teng ^b   Avecilla, Fernando ^c   Agarwal, Subhash M ^d   Azam, Amir ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c UNIVERSITY OF A CORUÑA   (Spain)

^d INSTITUTE OF CYTOLOGY AND PREVENTIVE ONCOLOGY   (India)

Author keywords

Antiprotozoal agents; Cytotoxicity; Docking; Entamoeba histolytica; Homology modeling; Plasmodium falciparum; Sulfonamides

Indexed keywords

4 [[4 (7 CHLOROQUINOLIN 4 YL)PIPERAZIN 1 YL]SULFONYL] N ACETYLANILINE; 7 CHLORO 4 (PIPERAZIN 1 YL)QUINOLINESULFONAMIDE DERIVATIVE; 7 CHLORO 4 [4 (2 NAPHTHYLSULFONYL)PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 (METHYLSULFONYL)PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 (PHENYLSULFONYL)PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 (PROPYLSULFONYL)PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(2,5 DICHLOROPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(2-NITROPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(4 CHLOROPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(4 METHOXYPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(4 METHYLPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; 7 CHLORO 4 [4 [(4 TERT BUTYLPHENYL)SULFONYL]PIPERAZIN 1 YL]QUINOLINE; ANTIPROTOZOAL AGENT; CHLOROQUINE; DIHYDROPTEROATE SYNTHASE; HEMATIN; QUININE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; ANTIPROTOZOAL AGENTS; CELL SURVIVAL; CHLOROQUINE; CRYSTALLOGRAPHY, X-RAY; DIHYDROPTEROATE SYNTHASE; DRUG RESISTANCE; ENTAMOEBA HISTOLYTICA; ERYTHROCYTES; HEMEPROTEINS; HEMOLYSIS; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PIPERAZINES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUININE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

ENTAMOEBA HISTOLYTICA; PLASMODIUM FALCIPARUM;

EID: 84877795200     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.052     Document Type: Article

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