The probiotic mixture VSL#3 dampens LPS-induced chemokine expression in human dendritic cells by inhibition of STAT-1 phosphorylation

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Mariman, Rob ^a,b   Tielen, Frans ^a   Koning, Frits ^b   Nagelkerken, Lex ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; PROBIOTIC AGENT; RNA; STAT1 PROTEIN; TRANSCRIPTION FACTOR; STAT1 PROTEIN, HUMAN;

ARTICLE; BONE MARROW CELL; CELL MATURATION; CELL SURFACE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN PHOSPHORYLATION; RNA ISOLATION; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION;

CELLS, CULTURED; CHEMOKINES; DENDRITIC CELLS; HUMANS; LIPOPOLYSACCHARIDES; PHOSPHORYLATION; PROBIOTICS; STAT1 TRANSCRIPTION FACTOR;

EID: 84919941092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115676     Document Type: Article

References (34)

1. Pabst O, Mowat AM (2012) Oral tolerance to food protein. Mucosal Immunol 5: 232-239.
2. Garrett WS, Gordon JI, Glimcher LH (2010) Homeostasis and inflammation in the intestine. Cell 140: 859-870.
3. Kayama H, Takeda K (2012) Regulation of intestinal homeostasis by innate and adaptive immunity. Int Immunol.
4. Maloy KJ, Powrie F (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474: 298-306.
5. van Baarlen P, Troost F, van der Meer C, Hooiveld G, Boekschoten M, et al. (2011) Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc Natl Acad Sci U S A 108 Suppl 1: 4562-4569.
6. Kelly D, Mulder IE (2012) Microbiome and immunological interactions. Nutr Rev 70 Suppl 1: S18-30.
7. Boirivant M, Strober W (2007) The mechanism of action of probiotics. Curr Opin Gastroenterol 23: 679-692.
8. Akira S (2009) Innate immunity to pathogens: Diversity in receptors for microbial recognition. Immunol Rev 227: 5-8.
9. Geijtenbeek TB, Gringhuis SI (2009) Signalling through C-type lectin receptors: Shaping immune responses. Nat Rev Immunol 9: 465-479.
10. Powrie F (2004) Immune regulation in the intestine: A balancing act between effector and regulatory T cell responses. Ann N Y Acad Sci 1029: 132-141.
11. Mariman R, Kremer B, van Erk M, Lagerweij T, Koning F, et al. (2012) Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics. Inflamm Bowel Dis 18: 1424-1433.
12. Gomez-Llorente C, Munoz S, Gil A (2010) Role of toll-like receptors in the development of immunotolerance mediated by probiotics. Proc Nutr Soc 69: 381-389.
13. Vanderpool C, Yan F, Polk DB (2008) Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis 14: 1585-1596.
14. Pamer EG (2007) Immune responses to commensal and environmental microbes. Nat Immunol 8: 1173-1178.
15. Coombes JL, Powrie F (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8: 435-446.
16. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, et al. (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2: 361-367.
17. Christensen HR, Frokiaer H, Pestka JJ (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168: 171-178.
18. Fink LN, Zeuthen LH, Ferlazzo G, Frokiaer H (2007) Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation. FEMS Immunol Med Microbiol 51: 535-546.
19. Mariman R, Kremer B, Koning F, Nagelkerken L (2014) The probiotic mixture VSL#3 mediates both pro- and anti-inflammatory responses in bone marrow-derived dendritic cells from C57BL/6 and BALB/c mice. Br J Nutr: 1-10.
20. Christensen HR, Frokiaer H, Pestka JJ (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168: 171-178.
21. Latvala S, Pietila TE, Veckman V, Kekkonen RA, Tynkkynen S, et al. (2008) Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells. World J Gastroenterol 14: 5570-83; discussion 5581-2.
22. Verbeek R, Bsibsi M, Plomp A, van Neerven RJ, te Biesebeke R, et al. (2010) Late rather than early responses of human dendritic cells highlight selective induction of cytokines, chemokines and growth factors by probiotic bacteria. Benef Microbes 1: 109-119.
23. Evrard B, Coudeyras S, Dosgilbert A, Charbonnel N, Alame J, et al. (2011) Dose-dependent immunomodulation of human dendritic cells by the probiotic lactobacillus rhamnosus Lcr35. PLoS One 6: e18735.
24. Mastrangeli G, Corinti S, Butteroni C, Afferni C, Bonura A, et al. (2009) Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses. Int Arch Allergy Immunol 150: 133-143.
25. Siegemund S, Sauer K (2012) Balancing pro- and anti-inflammatory TLR4 signaling. Nat Immunol 13: 1031-1033.
26. Kagan JC (2012) Defining the subcellular sites of innate immune signal transduction. Trends Immunol 33: 442-448.
27. Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, et al. (2012) LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages. FEBS Lett 586: 1540-1546.
28. Soler C, Felipe A, Garcia-Manteiga J, Serra M, Guillen-Gomez E, et al. (2003) Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochem J 375: 777-783.
29. Ramana CV, Gil MP, Schreiber RD, Stark GR (2002) Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 23: 96-101.
30. Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, et al. (2002) TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 3: 392-398.
31. Ohmori Y, Hamilton TA (2001) Requirement for STAT1 in LPS-induced gene expression in macrophages. J Leukoc Biol 69: 598-604.
32. Chung EY, Kim BH, Hong JT, Lee CK, Ahn B, et al. (2011) Resveratrol down-regulates interferon-gamma-inducible inflammatory genes in macrophages: Molecular mechanism via decreased STAT-1 activation. J Nutr Biochem 22: 902-909.
33. Chung EY, Roh E, Kwak JA, Lee HS, Lee SH, et al. (2010) Alpha-viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages. J Pharmacol Sci 112: 405-414.
34. Staab J, Herrmann-Lingen C, Meyer T (2013) Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression. PLoS One 8: e69903.