αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 51, 2014, Pages 18345-18350

  Devesa, Isabel ^a   Ferrándiz Huertas, Clotilde ^a   Mathivanan, Sakthikumar ^a   Wolf, Christoph ^a   Luján, Rafael ^b   Changeux, Jean Pierre ^c,d   Ferrer Montiel, Antonio ^a,e  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b Universidad Castilla La Mancha   (Spain)

^c Centre de Recherche Interdisciplinaire en Biologie   (France)

^d CNRS   (France)

^e CSIC UPV Unidad de Biofisica UBF   (Spain)

Author keywords

Inflammation; Ion channel; Nociception; Pain transduction; Sensory neuron

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA CALCITONIN GENE RELATED PEPTIDE; CALCIUM; VANILLOID RECEPTOR 1; CALCITONIN GENE RELATED PEPTIDE; PEPTIDE; SUBSTANCE P; TRPV1 PROTEIN, MOUSE; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; EXOCYTOSIS; GANGLION; GENE DELETION; GENE SILENCING; HYPERALGESIA; ION CURRENT; LARGE DENSE CORE VESICLE; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NERVE EXCITABILITY; NEWBORN; NONHUMAN; PAIN RECEPTOR; PEPTIDERGIC NERVOUS SYSTEM; PROTEIN SECRETION; RAT; SECRETORY PATHWAY; SECRETORY VESICLE; SENSORY NERVE CELL; ANIMAL; C57BL MOUSE; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; EXOCYTOSIS; GENE SILENCING; HYPERALGESIA; MICE, INBRED C57BL; NOCICEPTORS; PEPTIDES; RATS; RATS, WISTAR; SUBSTANCE P; TRPV CATION CHANNELS;

EID: 84919933654     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1420252111     Document Type: Article

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