Emotional detachment in psychopathy: Involvement of dorsal default-mode connections

Cortex

Volumn 62, Issue , 2015, Pages 11-19

  Sethi, Arjun ^a,b   Gregory, Sarah ^b   Dell'Acqua, Flavio ^a   Periche Thomas, Eva ^a   Simmons, Andy ^b   Murphy, Declan G M ^b   Hodgins, Sheilagh ^c   Blackwood, Nigel J ^b   Craig, Michael C ^a,b  

^a Natbrainlab   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cingulum; Default mode network; Diffusion MRI; Emotional detachment; Psychopathy

Indexed keywords

ADULT; ANTISOCIAL BEHAVIOR; ARTICLE; ASSESSMENT OF HUMANS; BEHAVIOR ASSESSMENT; CLINICAL ARTICLE; CONTROLLED STUDY; DEFAULT MODE NETWORK; DIFFUSION TENSOR IMAGING; EMOTION; EMOTIONAL DETACHMENT; FRACTIONAL ANISOTROPY; HUMAN; IMAGE ANALYSIS; INFORMATION PROCESSING; INTELLIGENCE QUOTIENT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OFFENDER; OUTCOME ASSESSMENT; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PSYCHOPATHY; PSYCHOPATHY CHECKLIST REVISED FACTOR 1; TRACTOGRAPHY; WHITE MATTER; AMYGDALOID NUCLEUS; ANTISOCIAL PERSONALITY DISORDER; BRAIN; BRAIN MAPPING; CASE CONTROL STUDY; CINGULATE GYRUS; MALE; MIDDLE AGED; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; OBJECT RELATION; PATHOLOGY; PSYCHOLOGY; TEMPORAL LOBE;

ADULT; AMYGDALA; ANTISOCIAL PERSONALITY DISORDER; BRAIN; BRAIN MAPPING; CASE-CONTROL STUDIES; CRIMINALS; DIFFUSION TENSOR IMAGING; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURAL PATHWAYS; OBJECT ATTACHMENT; PREFRONTAL CORTEX; TEMPORAL LOBE; WHITE MATTER;

EID: 84919907196     PISSN: 00109452     EISSN: 19738102     Source Type: Journal    
DOI: 10.1016/j.cortex.2014.07.018     Document Type: Article

References (89)

1. Ashtari M., Cervellione K., Cottone J., Ardekani B.A., Sevy S., Kumra S. Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. Journal of Psychiatric Research 2009, 43(3):189-204. 10.1016/j.jpsychires.2008.12.002.
2. Assaf M., Jagannathan K., Calhoun V.D., Miller L., Stevens M.C., Sahl R., et al. Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage 2010, 53(1):247-256. 10.1016/j.neuroimage.2010.05.067.
3. Bai F., Shi Y., Yuan Y., Wang Y., Yue C., Teng Y., et al. Altered self-referential network in resting-state amnestic type mild cognitive impairment. Cortex 2012, 48(5):604-613. 10.1016/j.cortex.2011.02.011.
4. Barrash J., Tranel D., Anderson S.W. Acquired personality disturbances associated with bilateral damage to the ventromedial prefrontal region. Developmental Neuropsychology 2000, 18(3):355-381. 10.1207/S1532694205Barrash.
5. Barry C.T., Frick P.J., DeShazo T.M., McCoy M.G., Ellis M., Loney B.R. The importance of callous-unemotional traits for extending the concept of psychopathy to children. Journal of Abnormal Psychology 2000, 109(2):335-340.
6. Basser P.J., Pajevic S., Pierpaoli C., Duda J., Aldroubi A. Invivo fiber tractography using DT-MRI data. Journal of Abnormal Psychology 2000, 44(4):625-632.
7. Blair R.J. Responding to the emotions of others: dissociating forms of empathy through the study of typical and psychiatric populations. Consciousness and Cognition 2005, 14(4):698-718. 10.1016/j.concog.2005.06.004.
8. Blair R.J. The amygdala and ventromedial prefrontal cortex: functional contributions and dysfunction in psychopathy. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 2008, 363(1503):2557-2565. 10.1098/rstb.2008.0027.
9. Blair R.J., Cipolotti L. Impaired social response reversal. A case of 'acquired sociopathy'. Brain 2000, 123(Pt 6):1122-1141.
10. Blair R.J., Colledge E., Murray L., Mitchell D.G. A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies. Journal of Abnormal Child Psychology 2001, 29(6):491-498.
11. Boccardi M., Frisoni G.B., Hare R.D., Cavedo E., Najt P., Pievani M., et al. Cortex and amygdala morphology in psychopathy. Psychiatry Research 2011, 193(2):85-92. 10.1016/j.pscychresns.2010.12.013.
12. Buckner R.L., Andrews-Hanna J.R., Schacter D.L. The brain's default network: anatomy, function, and relevance to disease. Annuals of the New York Academy of Sciences 2008, 1124:1-38. 10.1196/annals.1440.011.
13. Budhani S., Blair R.J. Response reversal and children with psychopathic tendencies: success is a function of salience of contingency change. Journal of Child Psychology and Psychiatry 2005, 46(9):972-981. 10.1111/j.1469-7610.2004.00398.x.
14. Budhani S., Richell R.A., Blair R.J. Impaired reversal but intact acquisition: probabilistic response reversal deficits in adult individuals with psychopathy. Journal of Abnormal Psychology 2006, 115(3):552-558. 10.1037/0021-843x.115.3.552.
15. Castellanos F.X., Proal E. Large-scale brain systems in ADHD: beyond the prefrontal-striatal model. Trends in Cognitive Sciences 2012, 16(1):17-26. 10.1016/j.tics.2011.11.007.
16. Catani M., Thiebault de Schotten M. Atlas of human brain connections 2012, Oxford University Press, Oxford.
17. Cooke D.J., Michie C. Psychopathy across cultures: North America and Scotland compared. Journal of Abnormal Psychology 1999, 108(1):58-68.
18. Craig M.C., Catani M., Deeley Q., Latham R., Daly E., Kanaan R., et al. Altered connections on the road to psychopathy. Molecular Psychiatry 2009, 14(10):946-953. 907. 10.1038/mp.2009.40.
19. Damasio H., Grabowski T., Frank R., Galaburda A.M., Damasio A.R. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 1994, 264(5162):1102-1105.
20. De Brito S.A., Mechelli A., Wilke M., Laurens K.R., Jones A.P., Barker G.J., et al. Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits. Brain 2009, 132(Pt 4):843-852. 10.1093/brain/awp011.
21. Dell'Acqua F., Scifo P., Rizzo G., Catani M., Simmons A., Scotti G., et al. A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution. NeuroImage 2010, 49(2):1446-1458. 10.1016/j.neuroimage.2009.09.033.
22. Ermer E., Cope L.M., Nyalakanti P.K., Calhoun V.D., Kiehl K.A. Aberrant paralimbic gray matter in criminal psychopathy. Journal of Abnormal Psychology 2012, 121(3):649-658. 10.1037/a0026371.
23. Filippi M., Agosta F., Scola E., Canu E., Magnani G., Marcone A., et al. Functional network connectivity in the behavioral variant of frontotemporal dementia. Cortex 2013, 49(9):2389-2401. 10.1016/j.cortex.2012.09.017.
24. Forsman M., Lichtenstein P., Andershed H., Larsson H. Genetic effects explain the stability of psychopathic personality from mid- to late adolescence. Journal of Abnormal Psychology 2008, 117(3):606-617. 10.1037/0021-843X.117.3.606.
25. Fox M.D., Snyder A.Z., Vincent J.L., Corbetta M., Van Essen D.C., Raichle M.E. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of the Sciences of the United States of America 2005, 102(27):9673-9678. 10.1073/pnas.0504136102.
26. Fransson P. Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Human Brain Mapping 2005, 26(1):15-29. 10.1002/hbm.20113.
27. Frick P.J., Kimonis E.R., Dandreaux D.M., Farell J.M. The 4 year stability of psychopathic traits in non-referred youth. Behavioural Sciences & the Law 2003, 21(6):713-736. 10.1002/bsl.568.
28. Frick P.J., Viding E. Antisocial behavior from a developmental psychopathology perspective. Developmental Psychopathology 2009, 21(4):1111-1131. 10.1017/s0954579409990071.
29. Glenn A.L., Raine A., Schug R.A. The neural correlates of moral decision-making in psychopathy. Molecular Psychiatry 2009, 14(1):5-6. 10.1038/mp.2008.104.
30. Greene J., Haidt J. How (and where) does moral judgment work?. Trends in Cognitive Science 2002, 6(12):517-523.
31. Greene J.D., Sommerville R.B., Nystrom L.E., Darley J.M., Cohen J.D. An fMRI investigation of emotional engagement in moral judgment. Science 2001, 293(5537):2105-2108. 10.1126/science.1062872.
32. Gregory S., Ffytche D., Simmons A., Kumari V., Howard M., Hodgins S., et al. The antisocial brain: psychopathy matters: a structural MRI investigation of antisocial male violent offenders. Archives of General Psychiatry 2012, 10.1001/archgenpsychiatry.2012.222.
33. Greicius M.D., Srivastava G., Reiss A.L., Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proceedings of the National Academy of the Sciences of the United States of America 2004, 101(13):4637-4642. 10.1073/pnas.0308627101.
34. Greicius M.D., Supekar K., Menon V., Dougherty R.F. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex 2009, 19(1):72-78. 10.1093/cercor/bhn059.
35. Gusnard D.A., Akbudak E., Shulman G.L., Raichle M.E. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of the Sciences of the United States of America 2001, 98(7):4259-4264. 10.1073/pnas.071043098.
36. Hare R.D. The hare psychopathy checklist - Revised 1991, Multi-Health Systems, Toronto, Ontario, Canada.
37. Hare R.D. The hare psychopathy checklist - Revised (PCL-R) manual 2003, Multi-Health Systems, Toronto, Ontario, Canada. 2nd ed.
38. Hare R.D., Harpur T.J., Hakstian A.R., Forth A.E., Hart S.D., Newman J.P. The revised psychopathy checklist: reliability and factor structure. Psychological Assessment 1990, 2(3):338-341. 10.1037/1040-3590.2.3.338.
39. Harlow J.M. Recovery from the passage of an iron bar through the head. 1868. History of Psychiatry 1993, 4(14):274-281. 10.1177/0957154x9300401407.
40. Harlow J.M. Passage of an iron rod through the head. 1848. The Journal of Neuropsychiatry and Clinical Neurosciences 1999, 11(2):281-283.
41. Harpur T.J., Hakstian A.R., Hare R.D. Factor structure of the psychopathy checklist. Journal of Consulting and Clinical Psychology 1988, 56(5):741-747.
42. Harpur T.J., Hare R.D., Hakstian A.R. Two-factor conceptualization of psychopathy: construct validity and assessment implications. Psychological Assessment 1989, 1(1):6-17. 10.1037/1040-3590.1.1.6.
43. Harris G.J., Jaffin S.K., Hodge S.M., Kennedy D., Caviness V.S., Marinkovic K., et al. Frontal white matter and cingulum diffusion tensor imaging deficits in alcoholism. Alcoholism: Clinical and Experimental Research 2008, 32(6):1001-1013. 10.1111/j.1530-0277.2008.00661.x.
44. Harrison B.J., Pujol J., López-Solà M., Hernández-Ribas R., Deus J., Ortiz H., et al. Consistency and functional specialization in the default mode brain network. Proceedings of the National Academy of the Sciences of the United States of America 2008, 105(28):9781-9786. 10.1073/pnas.0711791105.
45. Hart S.D., Hare R.D. Psychopathy: assessment and association with criminal conduct. Handbook of antisocial behaviour 1997, John Wiley & Sons, Inc, New York. D.M. Stoff, J. Breiling, J.D. Maser (Eds.).
46. Hemphill J.F., Hare R.D., Wong S. Psychopathy and recidivism: a review. Legal and Criminological Psychology 1998, 3(1):139-170. 10.1111/j.2044-8333.1998.tb00355.x.
47. Hoptman M.J., D'Angelo D., Catalano D., Mauro C.J., Shehzad Z.E., Kelly A.M., et al. Amygdalofrontal functional disconnectivity and aggression in schizophrenia. Schizophrenia Bulletin 2010, 36(5):1020-1028. 10.1093/schbul/sbp012.
48. Johnson M.K., Raye C.L., Mitchell K.J., Touryan S.R., Greene E.J., Nolen-Hoeksema S. Dissociating medial frontal and posterior cingulate activity during self-reflection. Social Cognitive & Affective Neuroscience 2006, 1(1):56-64. 10.1093/scan/nsl004.
49. Jones D.K., Williams S.C., Gasston D., Horsfield M.A., Simmons A., Howard R. Isotropic resolution diffusion tensor imaging with whole brain acquisition in a clinically acceptable time. Human Brain Mapping 2002, 15(4):216-230.
50. Juarez M., Kiehl K.A., Calhoun V.D. Intrinsic limbic and paralimbic networks are associated with criminal psychopathy. Human Brain Mapping 2012, 10.1002/hbm.22037.
51. Kelley W.M., Macrae C.N., Wyland C.L., Caglar S., Inati S., Heatherton T.F. Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience 2002, 14(5):785-794. 10.1162/08989290260138672.
52. Kiehl K.A. A cognitive neuroscience perspective on psychopathy: evidence for paralimbic system dysfunction. Psychiatry Research 2006, 142(2-3):107-128. 10.1016/j.psychres.2005.09.013.
53. Kiehl K.A., Hoffman M.B. The criminal psychopath: history, neuroscience, treatment, and economics. Jurimetrics 2011, 51(4):355-397.
54. Kiehl K.A., Smith A.M., Hare R.D., Mendrek A., Forster B.B., Brink J., et al. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry 2001, 50(9):677-684.
55. King H.E. Psychological effects of excitation of the limbic system. Electrical stimulation of the brain 1961, Hoggs Foundation, University of Texas Press, Houston, Texas,. D.E. Sheer (Ed.).
56. Kluver H., Bucy P.C. Preliminary analysis of functions of the temporal lobes in monkeys. 1939. The Journal of Neuropsychiatry and Clinical Neurosciences 1997, 9(4):606-620.
57. Koch K., Schultz C.C., Wagner G., Schachtzabel C., Reichenbach J.R., Sauer H., et al. Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia. Cortex 2013, 49(3):722-729. 10.1016/j.cortex.2012.02.001.
58. Koenigs M., Kruepke M., Zeier J., Newman J.P. Utilitarian moral judgment in psychopathy. Social Cognitive & Affective Neuroscience 2012, 7(6):708-714. 10.1093/scan/nsr048.
59. Lebel C., Walker L., Leemans A., Phillips L., Beaulieu C. Microstructural maturation of the human brain from childhood to adulthood. NeuroImage 2008, 40(3):1044-1055. 10.1016/j.neuroimage.2007.12.053.
60. Levenston G.K., Patrick C.J., Bradley M.M., Lang P.J. The psychopath as observer: emotion and attention in picture processing. Journal of Abnormal Psychology 2000, 109(3):373-385.
61. Lim K.O., Choi S.J., Pomara N., Wolkin A., Rotrosen J.P. Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biological Psychiatry 2002, 51(11):890-895.
62. Maddock R.J., Garrett A.S., Buonocore M.H. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Human Brain Mapping 2003, 18(1):30-41. 10.1002/hbm.10075.
63. Motzkin J.C., Newman J.P., Kiehl K.A., Koenigs M. Reduced prefrontal connectivity in psychopathy. Journal of Neuroscience 2011, 31(48):17348-17357. 10.1523/JNEUROSCI.4215-11.2011.
64. de Oliveira-Souza R., Hare R.D., Bramati I.E., Garrido G.J., Azevedo Ignacio F., Tovar-Moll F., et al. Psychopathy as a disorder of the moral brain: fronto-temporo-limbic grey matter reductions demonstrated by voxel-based morphometry. NeuroImage 2008, 40(3):1202-1213. 10.1016/j.neuroimage.2007.12.054.
65. Ochsner K.N., Knierim K., Ludlow D.H., Hanelin J., Ramachandran T., Glover G., et al. Reflecting upon feelings: an fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience 2004, 16(10):1746-1772. 10.1162/0898929042947829.
66. Pfefferbaum A., Rosenbloom M., Rohlfing T., Sullivan E.V. Degradation of association and projection white matter systems in alcoholism detected with quantitative fiber tracking. Biological Psychiatry 2009, 65(8):680-690. 10.1016/j.biopsych.2008.10.039.
67. Pfefferbaum A., Sullivan E.V. Disruption of brain white matter microstructure by excessive intracellular and extracellular fluid in alcoholism: evidence from diffusion tensor imaging. Neuropsychopharmacology 2005, 30(2):423-432. 10.1038/sj.npp.1300623.
68. Pujol J., Batalla I., Contreras-Rodriguez O., Harrison B.J., Pera V., Hernandez-Ribas R., et al. Breakdown in the brain network subserving moral judgment in criminal psychopathy. Social Cognitive & Affective Neuroscience 2011, 10.1093/scan/nsr075.
69. Raichle M.E., MacLeod A.M., Snyder A.Z., Powers W.J., Gusnard D.A., Shulman G.L. A default mode of brain function. Proceedings of the National Academy of the Sciences of the United States of America 2001, 98(2):676-682. 10.1073/pnas.98.2.676.
70. Raine A., Buchsbaum M., LaCasse L. Brain abnormalities in murderers indicated by positron emission tomography. Biological Psychiatry 1997, 42(6):495-508. 10.1016/s0006-3223(96)00362-9.
71. Raine A., Lencz T., Bihrle S., LaCasse L., Colletti P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry 2000, 57(2):119-127. discussion 128-119.
72. Rijsdijsk F.V., Viding E., De Brito S., Forgiarini M., Mechelli A., Jones A.P., et al. Heritable variations in gray matter concentration as a potential endophenotype for psychopathic traits. Archives of General Psychiatry 2010, 67(4):406-413. 10.1001/archgenpsychiatry.2010.20.
73. Sarkar S., Craig M.C., Catani M., Dell'acqua F., Fahy T., Deeley Q., et al. Frontotemporal white-matter microstructural abnormalities in adolescents with conduct disorder: a diffusion tensor imaging study. Psychological Medicine 2013, 43(2):401-411. 10.1017/S003329171200116X.
74. Saver J.L., Damasio A.R. Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia 1991, 29(12):1241-1249.
75. Shamay-Tsoory S.G., Harari H., Aharon-Peretz J., Levkovitz Y. The role of the orbitofrontal cortex in affective theory of mind deficits in criminal offenders with psychopathic tendencies. Cortex 2010, 46(5):668-677. 10.1016/j.cortex.2009.04.008.
76. Sheline Y.I., Barch D.M., Price J.L., Rundle M.M., Vaishnavi S.N., Snyder A.Z., et al. The default mode network and self-referential processes in depression. Proceedings of the National Academy of the Sciences of the United States of America 2009, 106(6):1942-1947. 10.1073/pnas.0812686106.
77. Shulman G.L., Fiez J.A., Corbetta M., Buckner R.L., Miezin F.M., Raichle M.E., et al. Common blood flow changes across visual tasks: II. Decreases in cerebral cortex. Journal of Cognitive Neuroscience 1997, 9(5):648-663. 10.1162/jocn.1997.9.5.648.
78. Skeem J.L., Cooke D.J. Is criminal behavior a central component of psychopathy? Conceptual directions for resolving the debate. Psychological Assessment 2010, 22(2):433-445. 10.1037/a0008512.
79. Sonuga-Barke E.J., Castellanos F.X. Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neuroscience & Biobehavioural Reviews 2007, 31(7):977-986. 10.1016/j.neubiorev.2007.02.005.
80. Spitzer R.L., Williams J.B., Gibbon M., First M.B. The structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description. Archives of General Psychiatry 1992, 49(8):624-629.
81. Sundram F., Deeley Q., Sarkar S., Daly E., Latham R., Craig M., et al. White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder. Cortex 2012, 48(2):216-229. 10.1016/j.cortex.2011.06.005.
82. Tournier J.D., Calamante F., Gadian D.G., Connelly A. Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution. NeuroImage 2004, 23(3):1176-1185. 10.1016/j.neuroimage.2004.07.037.
83. Tuch D.S., Reese T.G., Wiegell M.R., Makris N., Belliveau J.W., Wedeen V.J. High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Journal of Abnormal Psychology 2002, 48(4):577-582. 10.1002/mrm.10268.
84. Veit R., Flor H., Erb M., Hermann C., Lotze M., Grodd W., et al. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neuroscience Letters 2002, 328(3):233-236.
85. Viding E., Blair R.J., Moffitt T.E., Plomin R. Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry 2005, 46(6):592-597. 10.1111/j.1469-7610.2004.00393.x.
86. Vollm B.A., Taylor A.N., Richardson P., Corcoran R., Stirling J., McKie S., et al. Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. NeuroImage 2006, 29(1):90-98. 10.1016/j.neuroimage.2005.07.022.
87. Weschler D. WAIS-III: Administration and scoring manual 1997, Harcourt Brace and Co, San Antonio, Texas.
88. Wootton J.M., Frick P.J., Shelton K.K., Silverthorn P. Ineffective parenting and childhood conduct problems: the moderating role of callous-unemotional traits. Journal of Consulting and Clinical Psychology 1997, 65(2):301-308.
89. Yang Y., Raine A., Colletti P., Toga A.W., Narr K.L. Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths. Molecular Psychiatry 2009, 14(6):561-562. 555. 10.1038/mp.2009.12.