SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  TenNapel, Mindi J ^a   Lynch, Charles F ^a   Burns, Trudy L ^a   Wallace, Robert ^a   Smith, Brian J ^a   Button, Anna ^a   Domann, Frederick E ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXTRACELLULAR SUPEROXIDE DISMUTASE; PROTEIN KINASE; SIRTUIN 3; SIRTUIN 5; SIRTUIN 6; TRANSCRIPTION FACTOR FKHRL1; AKT1 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; PROTEIN KINASE B; SIRTUIN; SOD3 PROTEIN, HUMAN; SUPEROXIDE DISMUTASE;

ALCOHOL CONSUMPTION; ALLELE; ARTICLE; BODY MASS; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FOXO3 GENE; GENE; GENOTYPE; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MOLECULAR EPIDEMIOLOGY; OXIDATIVE STRESS; PROTEIN TARGETING; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SIRT3 GENE; SIRT5 GENE; SIRT6 GENE; SMOKING; SOD3 GENE; AGED; FEMALE; GENETICS; LONGEVITY; MALE; SEX DIFFERENCE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LONGEVITY; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-AKT; SEX FACTORS; SIRTUINS; SUPEROXIDE DISMUTASE;

EID: 84919905363     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115616     Document Type: Article

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