-
1
-
-
46449095702
-
Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia
-
Rami A., Bechmann I., Stehle J.H. Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog. Neurobiol. 2008, 85:273-296.
-
(2008)
Prog. Neurobiol.
, vol.85
, pp. 273-296
-
-
Rami, A.1
Bechmann, I.2
Stehle, J.H.3
-
2
-
-
42649146192
-
New players on center stage: sphingosine 1-phosphate and its receptors as drug targets
-
Huwiler A., Pfeilschifter J. New players on center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochem. Pharmacol. 2008, 75:1893-1900.
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 1893-1900
-
-
Huwiler, A.1
Pfeilschifter, J.2
-
3
-
-
70849086174
-
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
-
Brinkmann V. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. Br. J. Pharmacol. 2009, 158:1173-1182.
-
(2009)
Br. J. Pharmacol.
, vol.158
, pp. 1173-1182
-
-
Brinkmann, V.1
-
4
-
-
37849001331
-
Analysis of sphingosine 1-phosphate receptors in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools
-
Salomone S., Potts E.M., Tyndall S., et al. Analysis of sphingosine 1-phosphate receptors in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. Br. J. Pharmacol. 2008, 153:140-147.
-
(2008)
Br. J. Pharmacol.
, vol.153
, pp. 140-147
-
-
Salomone, S.1
Potts, E.M.2
Tyndall, S.3
-
5
-
-
2542461296
-
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury
-
Peng X., Hassoun P.M., Sammani S. Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am. J. Respir. Crit. Care Med. 2004, 169:1245-1251.
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.169
, pp. 1245-1251
-
-
Peng, X.1
Hassoun, P.M.2
Sammani, S.3
-
6
-
-
50049121874
-
Regulation and functions of sphingosine kinases in the brain
-
Bryan L., Kordula T., Spiegel S. Regulation and functions of sphingosine kinases in the brain. Biochim. Biophys. Acta 2008, 1781:459-466.
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 459-466
-
-
Bryan, L.1
Kordula, T.2
Spiegel, S.3
-
7
-
-
34047251154
-
Functions of the multifaceted family of sphingosine kinases, some close relatives
-
Spiegel S., Milstien S. Functions of the multifaceted family of sphingosine kinases, some close relatives. J. Biol. Chem. 2007, 282:2125-2129.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2125-2129
-
-
Spiegel, S.1
Milstien, S.2
-
8
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
Igarashi N., Okada T., Hayashi S., et al. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem. 2003, 278:46832-46839.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46832-46839
-
-
Igarashi, N.1
Okada, T.2
Hayashi, S.3
-
9
-
-
34848826331
-
Distribution of sphingosine kinase activity and mRNA in rodent brain
-
Blondeau N., Lai Y., Tyndall S., et al. Distribution of sphingosine kinase activity and mRNA in rodent brain. J. Neurochem. 2007, 103:509-517.
-
(2007)
J. Neurochem.
, vol.103
, pp. 509-517
-
-
Blondeau, N.1
Lai, Y.2
Tyndall, S.3
-
10
-
-
70349682405
-
Hypoxic preconditioning-induced cerebral ischemic tolerance. role of microvascular sphingosine kinase 2
-
Wacker B.K., Park T.S., Gidday J.M. Hypoxic preconditioning-induced cerebral ischemic tolerance. role of microvascular sphingosine kinase 2. Stroke 2009, 40:3342-3348.
-
(2009)
Stroke
, vol.40
, pp. 3342-3348
-
-
Wacker, B.K.1
Park, T.S.2
Gidday, J.M.3
-
11
-
-
70349327371
-
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia
-
Czech B., Pfeilschifter W., Mazaheri-Omrani N., et al. The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem. Biophys. Res. Commun. 2009, 389:251-256.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.389
, pp. 251-256
-
-
Czech, B.1
Pfeilschifter, W.2
Mazaheri-Omrani, N.3
-
12
-
-
77449106966
-
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
-
Hasegawa Y., Suzuki Y.H., Sozen T., et al. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 2010, 41:368-374.
-
(2010)
Stroke
, vol.41
, pp. 368-374
-
-
Hasegawa, Y.1
Suzuki, Y.H.2
Sozen, T.3
-
13
-
-
79551495392
-
Fingolimod provides long-term protection in rodent models of cerebral ischemia
-
Wei Y., Yemisci M., Kim H.H., et al. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann. Neurol. 2011, 69:119-129.
-
(2011)
Ann. Neurol.
, vol.69
, pp. 119-129
-
-
Wei, Y.1
Yemisci, M.2
Kim, H.H.3
-
14
-
-
0347481389
-
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases
-
Billich A., Bornancin F., Dévay P., et al. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J. Biol. Chem. 2003, 278:47408-47415.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47408-47415
-
-
Billich, A.1
Bornancin, F.2
Dévay, P.3
-
15
-
-
68949119768
-
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo
-
Pushparaj P.N., Manikandan J., Tay H.K. Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo. J. Immunol. 2009, 183:221-227.
-
(2009)
J. Immunol.
, vol.183
, pp. 221-227
-
-
Pushparaj, P.N.1
Manikandan, J.2
Tay, H.K.3
-
16
-
-
33751327483
-
Bench to bedside: the quest for quality in experimental stroke research
-
Dirnagl U. Bench to bedside: the quest for quality in experimental stroke research. J. Cereb. Blood Flow Metab. 2006, 26:1465-1478.
-
(2006)
J. Cereb. Blood Flow Metab.
, vol.26
, pp. 1465-1478
-
-
Dirnagl, U.1
-
17
-
-
70349659502
-
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression
-
Ren S., Babelova A., Moreth K., et al. Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney Int. 2009, 76:857-867.
-
(2009)
Kidney Int.
, vol.76
, pp. 857-867
-
-
Ren, S.1
Babelova, A.2
Moreth, K.3
-
18
-
-
32644444604
-
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
-
Zemann B., Kinzel B., Müller M. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood 2006, 107:1454-1458.
-
(2006)
Blood
, vol.107
, pp. 1454-1458
-
-
Zemann, B.1
Kinzel, B.2
Müller, M.3
-
19
-
-
33846811196
-
Regulation and functional roles of sphingosine kinases, Naunyn Schmiedebergs
-
Alemany R., Van Koppen C.J., Danneberg K. Regulation and functional roles of sphingosine kinases, Naunyn Schmiedebergs. Arch. Pharmacol. 2007, 374:413-428.
-
(2007)
Arch. Pharmacol.
, vol.374
, pp. 413-428
-
-
Alemany, R.1
Van Koppen, C.J.2
Danneberg, K.3
-
20
-
-
56549085199
-
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner
-
Hofmann L.P., Ren S., Schwalm S. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner. Biol. Chem. 2008, 389:1399-1407.
-
(2008)
Biol. Chem.
, vol.389
, pp. 1399-1407
-
-
Hofmann, L.P.1
Ren, S.2
Schwalm, S.3
-
21
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis
-
Liu H., Toman R.E., Goparaju S.K., et al. Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J. Biol. Chem. 2003, 278:40330-40336.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.K.3
-
22
-
-
58149174085
-
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury
-
Jo S.K., Bajwa A., Ye H., et al. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int. 2009, 75:167-175.
-
(2009)
Kidney Int.
, vol.75
, pp. 167-175
-
-
Jo, S.K.1
Bajwa, A.2
Ye, H.3
-
23
-
-
33847609611
-
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice
-
Zemann B., Urtz N., Reuschel R., et al. Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol. Lett. 2007, 109:56-63.
-
(2007)
Immunol. Lett.
, vol.109
, pp. 56-63
-
-
Zemann, B.1
Urtz, N.2
Reuschel, R.3
-
24
-
-
34250616679
-
Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor
-
Dudek S.M., Camp S.M., Chiang E.T., et al. Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. Cell. Signal. 2007, 19:1754-1764.
-
(2007)
Cell. Signal.
, vol.19
, pp. 1754-1764
-
-
Dudek, S.M.1
Camp, S.M.2
Chiang, E.T.3
|