-
1
-
-
50149120366
-
Cellular mechanism of tumor suppression by the retinoblastoma gene
-
PMID:18650841
-
Burkhart DL, Sage J. Cellular mechanism of tumor suppression by the retinoblastoma gene. Nat Rev Cancer 2008; 8:671-82; PMID:18650841; http://dx.doi. org/10.1038/nrc2399
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 671-682
-
-
Burkhart, D.L.1
Sage, J.2
-
2
-
-
14844342479
-
The retinoblastoma protein- from bench to bedside
-
PMID: 15819393
-
Mittnacht S. The retinoblastoma protein- from bench to bedside. Eur J Cell Biol 2005; 84:97-107; PMID: 15819393; http://dx.doi.org/10.1016/j.ejcb.2004. 12.012
-
(2005)
Eur J Cell Biol
, vol.84
, pp. 97-107
-
-
Mittnacht, S.1
-
3
-
-
0001510491
-
The RB and p53 pathways in cancer
-
Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002; 2:103-12; http://dx.doi.org/ 10.1016/S1535-6108(02)00102-2
-
(2002)
Cancer Cell
, vol.2
, pp. 103-112
-
-
Sherr, C.J.1
McCormick, F.2
-
4
-
-
50149084928
-
Tailoring to Rb: Tumour suppressor status and therapeutic response
-
PMID:19143056
-
Knudsen ES, Knudsen KE. Tailoring to Rb: tumour suppressor status and therapeutic response. Nat Rev Cancer 2008; 8:714-24; PMID:19143056; http://dx. doi.org/10.1038/nrc2401
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 714-724
-
-
Knudsen, E.S.1
Knudsen, K.E.2
-
5
-
-
76749104377
-
Targeting the RB-pathway in cancer therapy
-
PMID:20145169
-
Knudsen ES, Wang JYJ. Targeting the RB-pathway in cancer therapy. Clin Cancer Res 2110; 16:1094-9; PMID:20145169; http://dx.doi.org/10.1158/1078-0432.CCR-09-0787
-
Clin Cancer Res
, vol.2110
, Issue.16
, pp. 1094-1099
-
-
Knudsen, E.S.1
Wang, J.Y.J.2
-
6
-
-
84861497210
-
Inhibitors of cell cycle kinases: Recent advances and future prospects as cancer therapeutics
-
PMID:22471707
-
Stone A, Sutherland RL, Musgrove EA. Inhibitors of cell cycle kinases: recent advances and future prospects as cancer therapeutics. Crit Rev in Oncog 2012; 17:175-98; PMID:22471707; http://dx.doi.org/ 10.1615/CritRevOncog.v17.i2.40
-
(2012)
Crit Rev in Oncog
, vol.17
, pp. 175-198
-
-
Stone, A.1
Sutherland, R.L.2
Musgrove, E.A.3
-
7
-
-
0029849620
-
Cancer cell cycles
-
Sherr CJ. Cancer Cell cycles. Science 1996; 274:1672-7; http://dx.doi.org/10.1126/science.274.5293.1672
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
8
-
-
57149119271
-
SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGFbeta homeostasis in lung cancer cells
-
PMID:19047146
-
Jeon HS, Dracheva T, Tang SH, Meerzaman D, Fukuoka J, Shakoori A, Shilo K, Travis WD, Jen J. SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGFbeta homeostasis in lung cancer cells. Cancer Res 2008; 68:9686-92; PMID:19047146; http://dx.doi.org/ 10.1158/0008-5472.CAN-08-1083
-
(2008)
Cancer Res
, vol.68
, pp. 9686-9692
-
-
Jeon, H.S.1
Dracheva, T.2
Tang, S.H.3
Meerzaman, D.4
Fukuoka, J.5
Shakoori, A.6
Shilo, K.7
Travis, W.D.8
Jen, J.9
-
9
-
-
0033796320
-
Rb-dependent S-phase response to DNA damage
-
PMID: 11003670
-
Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AF, Hunton IC, Feramisco JR, Wang JYJ, Knudsen ES. Rb-dependent S-phase response to DNA damage. Mol Cell Biol 2000; 20:7751-63; PMID: 11003670; http://dx.doi.org/10.1128/MCB.20.20. 7751-7763.2000
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7751-7763
-
-
Knudsen, K.E.1
Booth, D.2
Naderi, S.3
Sever-Chroneos, Z.4
Fribourg, A.F.5
Hunton, I.C.6
Feramisco, J.R.7
Wang, J.Y.J.8
Knudsen, E.S.9
-
10
-
-
33646239607
-
Discovery and evaluation of dual cdk1 and cdk2 inhibitors
-
PMID: 16618755
-
Payton M, Chung G, Yakowec P, Wong A, Powers D, Xiong L, Zhang N, Leal J, Bush TL, Santora V, et al. Discovery and evaluation of dual cdk1 and cdk2 inhibitors. Cancer Res 2006; 66:4299-308; PMID: 16618755; http://dx.doi.org/10.1158/0008-5472. CAN-05-2507
-
(2006)
Cancer Res
, vol.66
, pp. 4299-4308
-
-
Payton, M.1
Chung, G.2
Yakowec, P.3
Wong, A.4
Powers, D.5
Xiong, L.6
Zhang, N.7
Leal, J.8
Bush, T.L.9
Santora, V.10
-
11
-
-
35148842941
-
Cell Cycle dependent and schedule dependent antitumor effects of sorafenib combined with radiation
-
PMID:17909054
-
Plastaras JP, Kim SH, Liu YY, Dicker DT, Dorsey JF, McDonough J, Cerniglia G, Rajendran RR, Gupta A, Rustgi AK, et al. Cell Cycle dependent and schedule dependent antitumor effects of sorafenib combined with radiation. Cancer Res 2007; 67:9443-54; PMID:17909054; http://dx.doi.org/10.1158/0008-5472.CAN-07-1473
-
(2007)
Cancer Res
, vol.67
, pp. 9443-9454
-
-
Plastaras, J.P.1
Kim, S.H.2
Liu, Y.Y.3
Dicker, D.T.4
Dorsey, J.F.5
McDonough, J.6
Cerniglia, G.7
Rajendran, R.R.8
Gupta, A.9
Rustgi, A.K.10
-
12
-
-
46749089975
-
Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis
-
PMID:18360108
-
De Leon G, Sherry TC, Krucher NA. Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis. Cancer Bio Ther 2008; 7: 833-9; PMID:18360108; http://dx.doi.org/ 10.4161/cbt.7.6.5839
-
(2008)
Cancer Bio Ther
, vol.7
, pp. 833-839
-
-
De Leon, G.1
Sherry, T.C.2
Krucher, N.A.3
-
13
-
-
0029052647
-
Induction of a retinoblastoma phosphatase by anticancer drugs accompanies p53-independent G1 arrest and apoptosis
-
PMID:7568064
-
Dou QP, An B, Will PL. Induction of a retinoblastoma phosphatase by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. PNAS USA 1995; 92:9019-23; PMID:7568064; http://dx.doi.org/ 10.1073/pnas.92.20.9019
-
(1995)
PNAS USA
, vol.92
, pp. 9019-9023
-
-
Dou, Q.P.1
An, B.2
Will, P.L.3
-
14
-
-
57649123145
-
Stress and IGF-1 differentially control cell fate through mammalian target of rapamycin mTOR. And retinoblastoma protein (pRb)
-
PMID:18697743
-
Popowski M, Ferguson HA, Sion AM, Koller E, Knudsen E, Van Den Berg CL. Stress and IGF-1 differentially control cell fate through mammalian target of rapamycin (mTOR. and retinoblastoma protein (pRb). J Biol Chem 2008; 283:28265-73; PMID:18697743; http://dx.doi.org/10.1074/jbc. M805724200
-
(2008)
J Biol Chem
, vol.283
, pp. 28265-28273
-
-
Popowski, M.1
Ferguson, H.A.2
Sion, A.M.3
Koller, E.4
Knudsen, E.5
Van Den Berg, C.L.6
-
15
-
-
84866293656
-
Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition
-
PMID: 22895174
-
Lentine B, Antonucci L, Hunce R, Edwards J, Marallano V, Krucher NA. Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition. Cell Cycle 2012; 11:3324-30; PMID: 22895174; http://dx.doi.org/10.4161/cc.21693
-
(2012)
Cell Cycle
, vol.11
, pp. 3324-3330
-
-
Lentine, B.1
Antonucci, L.2
Hunce, R.3
Edwards, J.4
Marallano, V.5
Krucher, N.A.6
-
16
-
-
33644775511
-
Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli
-
PMID: 16205627
-
Masselli A, Wang JYJ. Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli. Oncogene 2006; 25:1290-8; PMID: 16205627; http://dx.doi.org/10.1038/sj.onc.1209161
-
(2006)
Oncogene
, vol.25
, pp. 1290-1298
-
-
Masselli, A.1
Wang, J.Y.J.2
-
17
-
-
0031016121
-
Rb kinases and Rb binding proteins: New points of view
-
PMID:9020586
-
Taya Y. Rb kinases and Rb binding proteins: new points of view. Trends Biochem Sci 1997; 22:14-7; PMID:9020586; http://dx.doi.org/10.1016/S0968-0004(96)10070-0
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 14-17
-
-
Taya, Y.1
-
18
-
-
77952387813
-
Phos-phorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding
-
PMID:20223825
-
Burke JR, Deshong AJ, Pelton JG, Rubin SM. Phos-phorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J Biol Chem 2010; 285:16286-93; PMID:20223825; http://dx.doi.org/10.1074/jbc. M110.108167
-
(2010)
J Biol Chem
, vol.285
, pp. 16286-16293
-
-
Burke, J.R.1
Deshong, A.J.2
Pelton, J.G.3
Rubin, S.M.4
-
19
-
-
79551622682
-
P38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
-
PMID:20871633
-
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW. p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene 2011; 30:588-99; PMID:20871633; http://dx.doi.org/ 10.1038/onc.2010.442
-
(2011)
Oncogene
, vol.30
, pp. 588-599
-
-
Delston, R.B.1
Matatall, K.A.2
Sun, Y.3
Onken, M.D.4
Harbour, J.W.5
-
20
-
-
0029924241
-
Differential regulation of retinoblastoma protein function by specific cdk phosphorylation sites
-
PMID:8626527
-
Knudsen ES, Wang JYJ. Differential regulation of retinoblastoma protein function by specific cdk phosphorylation sites. J Biol Chem 1996; 271:8313-20; PMID:8626527; http://dx.doi.org/10.1074/jbc.271. 14.8313
-
(1996)
J Biol Chem
, vol.271
, pp. 8313-8320
-
-
Knudsen, E.S.1
Wang, J.Y.J.2
-
21
-
-
0030849455
-
Dual mechanisms for the inhibition of E2F binding to Rb by cyclin-dependent kinase mediated Rb phosphorylation
-
PMID:9315635
-
Knudsen ES, Wang JYJ. Dual mechanisms for the inhibition of E2F binding to Rb by cyclin-dependent kinase mediated Rb phosphorylation. Mol Cell Bio 1997; 17:5771-83; PMID:9315635
-
(1997)
Mol Cell Bio
, vol.17
, pp. 5771-5783
-
-
Knudsen, E.S.1
Wang, J.Y.J.2
-
22
-
-
84871513029
-
Deciphering the retinoblastoma protein phosphorylation code
-
PMID:23218751
-
Rubin SM, Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem Sci 2013; 38:12-9; PMID:23218751; http://dx.doi.org/10.1016/ j.tibs.2012.10.007
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 12-19
-
-
Rubin, S.M.1
-
23
-
-
0038143215
-
Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb
-
PMID:12646568
-
Ma D, Zhou P, Harbour JW. Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb. J Biol Chem 2003; 278:19358-66; PMID:12646568; http://dx.doi.org/10.1074/jbc. M301761200
-
(2003)
J Biol Chem
, vol.278
, pp. 19358-19366
-
-
Ma, D.1
Zhou, P.2
Harbour, J.W.3
-
24
-
-
18144403123
-
Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis
-
PMID:15716273
-
Agdebola O, Pasternack GR. Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis. J Biol Chem 2005; 280:15497-502; PMID:15716273; http://dx.doi.org/ 10.1074/jbc.M411382200
-
(2005)
J Biol Chem
, vol.280
, pp. 15497-15502
-
-
Agdebola, O.1
Pasternack, G.R.2
-
25
-
-
67651113436
-
Evidence for a mitochondrial localization of the retinoblastoma Protein
-
Ferecatu I, Le Floch N, Bergeaud M, Rodŕguez-Enfedaque A, Rincheval V, Oliver L, Vallette FM, Mignotte B, Vayssìere J-L. Evidence for a mitochondrial localization of the retinoblastoma Protein. BMC Cell Biol 2009; 10:50; http://dx.doi.org/10.1186/1471-2121-10-50
-
(2009)
BMC Cell Biol
, vol.10
, pp. 50
-
-
Ferecatu, I.1
Le Floch, N.2
Bergeaud, M.3
Rodŕguez-Enfedaque, A.4
Rincheval, V.5
Oliver, L.6
Vallette, F.M.7
Mignotte, B.8
Vayssìere, J.-L.9
-
26
-
-
84877246101
-
The retinoblastoma protein induces apoptosis directly at the mitochondria
-
Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev 2013; 27:1003-15; http:// dx.doi.org/10.1101/gad.211326.112
-
(2013)
Genes Dev
, vol.27
, pp. 1003-1015
-
-
Hilgendorf, K.I.1
Leshchiner, E.S.2
Nedelcu, S.3
Maynard, M.A.4
Calo, E.5
Ianari, A.6
Walensky, L.D.7
Lees, J.A.8
-
27
-
-
82355181105
-
Bax unleashed: The biochemical transformation of an inactive cytosolic monomer into a mitochondrial pore
-
PMID:21978892
-
Walensky LD, Gavathiotis E. Bax unleashed: the biochemical transformation of an inactive cytosolic monomer into a mitochondrial pore. Trends Biochem Sci 2011; 36:642-52; PMID:21978892; http://dx.doi.org/ 10.1016/j.tibs.2011.08.009
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 642-652
-
-
Walensky, L.D.1
Gavathiotis, E.2
-
28
-
-
77950425803
-
PNUTS knockdown potentiates the apoptotic effect of roscovitine in breast and colon cancer cells
-
PMID:20372802
-
De Leon G, Cavino M, D'Angelo M, Krucher NA. PNUTS knockdown potentiates the apoptotic effect of roscovitine in breast and colon cancer cells. Int J Oncol 2010; 36:1269-75; PMID:20372802
-
(2010)
Int J Oncol
, vol.36
, pp. 1269-1275
-
-
De Leon, G.1
Cavino, M.2
D'Angelo, M.3
Krucher, N.A.4
-
30
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer, Cell 2000; 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
31
-
-
0028861428
-
Inhibition of apoptosis by retinoblastoma gene product
-
Haas-Kogan D, Kogan SC, Levi D, Dazin P, T'Ang A, Fung Y-KT, Isreal MA. Inhibition of apoptosis by retinoblastoma gene product. EMBO J 1995;14: 461-72.
-
(1995)
EMBO J
, vol.14
, pp. 461-472
-
-
Haas-Kogan, D.1
Kogan, S.C.2
Levi, D.3
Dazin, P.4
T'Ang, A.5
Fung, Y.-K.T.6
Isreal, M.A.7
-
32
-
-
2942564711
-
Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation
-
PMID: 15121862
-
Chau BN, Chen T-T, Wan YY, DeGregori J, Wang JYJ. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cel Biol 2004; 24:4438-47; PMID: 15121862; http://dx.doi.org/10.1128/MCB.24.10. 4438-4447.2004
-
(2004)
Mol Cel Biol
, vol.24
, pp. 4438-4447
-
-
Chau, B.N.1
Chen, T.-T.2
Wan, Y.Y.3
DeGregori, J.4
Wang, J.Y.J.5
-
33
-
-
0034640375
-
Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinasestress-activated protein kinase
-
PMID:10799486
-
Shim J, Park H-S, Kim MJ, Park J, Park E, Cho S-G, Eom S-J, Lee H-W, Joe CO, Choi E-J. Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinasestress-activated protein kinase. J Biol Chem 2000; 275:14107-11; PMID:10799486; http://dx.doi.org/10.1074/jbc.275. 19.14107
-
(2000)
J Biol Chem
, vol.275
, pp. 14107-14111
-
-
Shim, J.1
Park, H.-S.2
Kim, M.J.3
Park, J.4
Park, E.5
Cho, S.-G.6
Eom, S.-J.7
Lee, H.-W.8
Joe, C.O.9
Choi, E.-J.10
-
34
-
-
0033081905
-
Cell cycle models for molecular biology and molecular oncology: Exploring new dimensions
-
PMID: 10554165
-
Shackney SE, Shankey TV. Cell cycle models for molecular biology and molecular oncology: exploring new dimensions. Cytometry 1999; 35:97-116; PMID: 10554165; http://dx.doi.org/10.1002/(SICI)1097-0320(19990201)35:2〈97::AID-CYTO1〉3.0.CO;2-5
-
(1999)
Cytometry
, vol.35
, pp. 97-116
-
-
Shackney, S.E.1
Shankey, T.V.2
-
35
-
-
84871513029
-
Deciphering the retinoblastoma protein phosphorylation code
-
PMID: 23218751
-
Rubin SM. Deciphering the retinoblastoma protein phosphorylation code. TIBS 2013; 38:12-9; PMID: 23218751; http://dx.doi.org/10.1016/j.tibs.2012. 10.007
-
(2013)
TIBS
, vol.38
, pp. 12-19
-
-
Rubin, S.M.1
-
36
-
-
0031172801
-
Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells
-
PMID:9197238
-
Berndt N, Dohadwala M, Liu CWY. Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells. Curr Biol 1997; 7:375-86; PMID:9197238; http://dx.doi.org/10.1016/S0960-9822(06)00185-0
-
(1997)
Curr Biol
, vol.7
, pp. 375-386
-
-
Berndt, N.1
Dohadwala, M.2
Liu, C.W.Y.3
-
37
-
-
0035959632
-
Protein phosphatase 1α-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein
-
PMID: 11593419
-
Wang R-H, Liu CWY, Avramis VI, Berndt N. Protein phosphatase 1α-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein. Oncogene 2001; 20:6111-22; PMID: 11593419; http://dx.doi.org/10.1038/sj.onc.1204829
-
(2001)
Oncogene
, vol.20
, pp. 6111-6122
-
-
Wang, R.-H.1
Liu, C.W.Y.2
Avramis, V.I.3
Berndt, N.4
-
38
-
-
0034676341
-
Interaction of the retinoblastoma protein (pRb) with the catalytic subunit of DNA polymerase δ (p125)
-
PMID:11114723
-
Krucher NA, Zygmunt A, Mazloum N, Tamrakar S, Ludlow JW, Lee YMWT. Interaction of the retinoblastoma protein (pRb) with the catalytic subunit of DNA polymerase δ (p125). Oncogene 2000; 19:5464-70; PMID:11114723; http://dx.doi.org/10.1038/sj.onc. 1203930
-
(2000)
Oncogene
, vol.19
, pp. 5464-5470
-
-
Krucher, N.A.1
Zygmunt, A.2
Mazloum, N.3
Tamrakar, S.4
Ludlow, J.W.5
Lee, Y.M.W.T.6
|