Does Implant Coating With Antibacterial-Loaded Hydrogel Reduce Bacterial Colonization and Biofilm Formation in Vitro?

Clinical Orthopaedics and Related Research

Volumn 472, Issue 11, 2014, Pages 3311-3323

  Drago, Lorenzo ^a   Boot, Willemijn ^b   Dimas, Kostantinos ^c   Malizos, Kostantinos ^c   Hänsch, Gertrud M ^d   Stuyck, Jos ^e   Gawlitta, Debby ^b   Romanò, Carlo L ^a  

^a IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMIKACIN; ANTIBIOTIC AGENT; CIPROFLOXACIN; CRYSTAL VIOLET; DAPTOMYCIN; DICLOFENAC; GENTAMICIN; MEROPENEM; RIFAMPICIN; SALICYLATE SODIUM; TOBRAMYCIN; VANCOMYCIN; ANTIINFECTIVE AGENT; BIOMATERIAL; DRUG CARRIER; HYDROGEL;

ACINETOBACTER BAUMANNII; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BIOFILM; BROTH DILUTION; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; FEMUR; HUMAN; HUMAN TISSUE; HYDROGEL; IMPLANT; IN VITRO STUDY; METHICILLIN-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS EPIDERMIDIS; TIBIA; ANIMAL; BIODEGRADABLE IMPLANT; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EVALUATION STUDY; FEASIBILITY STUDY; MICROBIAL SENSITIVITY TEST; PROCEDURES; PROSTHESIS-RELATED INFECTIONS; RABBIT; STAPHYLOCOCCUS AUREUS; SURGERY;

ABSORBABLE IMPLANTS; ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; COATED MATERIALS, BIOCOMPATIBLE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; FEMUR; HUMANS; HYDROGEL; IN VITRO TECHNIQUES; MICROBIAL SENSITIVITY TESTS; PROSTHESIS-RELATED INFECTIONS; RABBITS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; TIBIA;

EID: 84919865009     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-014-3558-1     Document Type: Article

References (42)

1. Antoci V Jr, Adams CS, Hickok NJ, Shapiro IM, Parvizi J. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin Orthop Relat Res. 2007;462:200–206.
2. Antoci V Jr, Adams CS, Parvizi J, Ducheyne P, Shapiro IM, Hickok NJ. Covalently attached vancomycin provides a nanoscale antibacterial surface. Clin Orthop Relat Res. 2007;461:81–87.
3. Antoci V Jr, King SB, Jose B, Parvizi J, Zeiger AR, Wickstrom E, Freeman TA, Composto RJ, Ducheyne P, Shapiro IM, Hickok NJ, Adams CS. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J Orthop Res. 2007;25:858–866.
4. Arciola CR. New concepts and new weapons in implant infections. Int J Artif Organs. 2009;32:533–536.
5. Barth E, Myrvik QM, Wagner W, Gristina AG. In vitro and in vivo comparative colonization of Staphylococcus aureus and Staphylococcus epidermidis on orthopaedic implant materials. Biomaterials. 1989;10:325–328.
6. Billon A, Chabaud L, Gouyette A, Bouler JM, Merle C. Vancomycin biodegradable poly(lactide-co-glycolide) microparticles for bone implantation: influence of the formulation parameters on the size, morphology, drug loading and in vitro release. J Microencapsul. 2005;22:841–852
7. Bongaerts JH, Cooper‐White JJ, Stokes JR. Low biofouling chitosan-hyaluronic acid multilayers with ultra-low friction coefficients. Biomacromolecules. 2009;10:1287–1294.
8. Bonnevialle P, Bonnomet F, Philippe R, Loubignac F, Rubens-Duval B, Talbi A, Le Gall C, Adam P; SOFCOT. Early surgical site infection in adult appendicular skeleton trauma surgery: a multicenter prospective series. Orthop Traumatol Surg Res. 2012;98:684–689.
9. Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, Rubash HE, Berry DJ. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res. 2010;468:45–51.
10. Buttaro MA, Pusso R, Piccaluga F. Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty: two-stage revision results. J Bone Joint Surg Br. 2005;87:314–319.
11. Campoccia D, Montanaro L, Arciola CR. A review of the biomaterials technologies for infection-resistant surfaces. Biomaterials. 2013;34:8533–8554.
12. Christensen GD, Simpson WA, Younger JJ, Baddour LM, Barrett FF, Melton DM, Beachey EH. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J ClinMicrobiol 1985;22:996–1006.
13. Cierny G 3rd, DiPasquale D. Periprosthetic total joint infections: staging, treatment, and outcomes. Clin Orthop Relat Res. 2002;403:23–28.
14. Collins I, Wilson-MacDonald J, Chami G, Burgoyne W, Vineyakam P, Berendt T, Fairbank J The diagnosis and management of infection following instrumented spinal fusion. Eur Spine J. 2008;17:445–450.
15. Costerton JW. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res. 2005;437:7–11.
16. Desrousseaux C, Sautou V, Descamps S, Traoré O. Modification of the surfaces of medical devices to prevent microbial adhesion and biofilm formation. J Hosp Infect. 2013;85:87–93.
17. Drago L, De Vecchi E, Mattina R, Romanò CL. Activity of N-acetyl-L-cysteine against biofilm of Staphylococcus aureus and Pseudomonas aeruginosa on orthopedic prosthetic materials. Int J Artif Organs. 2013;36:39–46.
18. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res. 1996;333:245–251.
19. Flückiger U, Zimmerli W. Factors influencing antimicrobial therapy of surface adhering microorganisms. Recent Res Devel Antimicrob Agents Chemother. 2000;4:165–175.
20. Fu J, Ji J, Fan D, Shen J. Construction of antibacterial multilayer films containing nanosilver via layer-by-layer assembly of heparin and chitosan-silver ions complex. J Biomed Mater Res A. 2006;79:665–674.
21. García-Fernández L, Cui J, Serrano C, Shafiq Z, Gropeanu RA, Miguel VS, Ramos JI, Wang M, Auernhammer GK, Ritz S, Golriz AA, Berger R, Wagner M, del Campo A. Antibacterial strategies from the sea: polymer-bound cl-catechols for prevention of biofilm formation. Adv Mater. 2013;25:529–533.
22. Giavaresi G, Meani E, Sartori M, Ferrari A, Bellini D, Sacchetta AC, Meraner J, Sambri A, Vocale C, Sambri V, Fini M, Romanò CL. Efficacy of antibacterial-loaded coating in an in vivo model of acutely highly contaminated implant. Int Orthop. 2013 December 22 [Epub ahead of print].
23. Hickok NJ, Shapiro IM. Immobilized antibiotics to prevent orthopaedic implant infections. Adv Drug Deliv Rev. 2012;64:1165–1176.
24. Humphrey JS, Mehta S, Seaber AV, Vail TP. Pharmacokinetics of a degradable drug delivery system in bone. Clin Orthop Relat Res. 1998;349:218–224.
25. Isefuku S, Joyner CJ, Simpson AH. Toxic effect of rifampicin on human osteoblast-like cells. J Orthop Res. 2001;19:950–954.
26. Kalicke T, Schierholz J, Schlegel U, Frangen TM, Koller M, Printzen G, Seybold D, Klockner S, Muhr G, Arens S. Effect on infection resistance of a local antiseptic and antibiotic coating on osteosynthesis implants: an in vitro and in vivo study. J Orthop Res. 2006;24:1622–1640.
27. Kluin OS, van der Mei HC, Busscher HJ, Neut D. Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin Drug Deliv. 2013;10:341–351.
28. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780–785.
29. Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520–532.
30. McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis MJ. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res. 2002;403:8–15.
31. Mody RM, Zapor M, Hartzell JD, Robben PM, Waterman P, Wood-Morris R, Trotta R, Andersen RC, Wortmann G. Infectious complications of damage control orthopedics in war trauma. J Trauma. 2009;67:758–761.
32. Moriarty TF, Schlegel U, Perren S, Richards RG. Infection in fracture fixation: can we influence infection rates through implant design? J Mater Sci Mater Med. 2010;21:1031–1035.
33. Neut D, van de Belt H, Stokroos I, van Horn JR, van der Mei HC, Busscher HJ. Biomaterial-associated infection of gentamicin-loaded PMMA beads in orthopaedic revision surgery. J Antimicrob Chemother. 2001;47:885–891.
34. Petty W, Spanier S, Shuster JJ, Silverthorne C. The influence of skeletal implants on incidence of infection: experiments in a canine model. J Bone Joint Surg Am. 1985;67:1236–1244.
35. Pitarresi G, Palumbo FS, Calascibetta F, Fiorica C, Di Stefano M, Giammona G. Medicated hydrogels of hyaluronic acid derivatives for use in orthopedic field. Int J Pharm. 2013;449:84–94.
36. Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res. 2008; 466:1710–1715.
37. Romanò CL, Toscano M, Romanò D, Drago L. Antibiofilm agents and implant-related infections in orthopaedics: where are we? J Chemother. 2013;25:67–80.
38. Tan HL, Lin WT, Tang TT. The use of antimicrobial-impregnated PMMA to manage periprosthetic infections: controversial issues and the latest developments. Int J Artif Organs. 2012;35:832–839.
39. Tsuchiya H, Shirai T, Nishida H, Murakami H, Kabata T, Yamamoto N, Watanabe K, Nakase J. Innovative antimicrobial coating of titanium implants with iodine. J Orthop Sci. 2012;17:595–604.
40. Weinstein MA, McCabe JP, Cammisa FP Jr. Postoperative spinal wound infection: a review of 2,391 consecutive index procedures. J Spinal Disord. 2000t;13:422–426.
41. Witsø E, Persen L, Benum P, Bergh K. Release of netilmicin and vancomycin from cancellous bone. Acta Orthop Scand. 2002;73:199–205.
42. Zimmerli W, Moser C. Pathogenesis and treatment concepts of orthopaedic biofilm infections. FEMS Immunol Med Microbiol. 2012;65:158–168.