Effect of Carr-Purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 Tesla

Magnetic Resonance in Medicine

Volumn 73, Issue 1, 2015, Pages 13-20

  Deelchand, Dinesh Kumar ^a   Henry, Pierre Gilles ^a   Marjańska, Małgorzata ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Brain; CP pulse train; LASER; LCModel; T2

Indexed keywords

AMINO ACIDS; BIOMOLECULES; BRAIN; EXPONENTIAL FUNCTIONS; LASERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RATS; RELAXATION TIME; TISSUE;

COUPLED SPINS; LCMODEL; MULTIPLE-ECHO; N-ACETYLASPARTATE; PULSE TRAIN; RAT BRAIN IN VIVO; T2 RELAXATION; TRANSVERSE RELAXATION TIME;

METABOLITES;

CHOLINE; GLUTAMINE; TAURINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CARR PURCELL REFOCUSING PULSE TRAIN; COMPARATIVE STUDY; HUMAN; HUMAN TISSUE; IMAGE PROCESSING; IMAGING AND DISPLAY; IN VIVO STUDY; LASER; LOCALIZATION BY ADIABATIC SELECTIVE REFOCUSING; MAGNET; MAGNETIC FIELD; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RELAXATION TIME; TISSUE WATER; ALGORITHM; ANATOMY AND HISTOLOGY; ANIMAL; BRAIN; COMPUTER ASSISTED DIAGNOSIS; METABOLISM; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ALGORITHMS; ANIMALS; BRAIN; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR IMAGING; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING, COMPUTER-ASSISTED; TISSUE DISTRIBUTION;

EID: 84919847486     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25088     Document Type: Article

References (39)

1. Garwood M, Dela Barre L. The return of the frequency sweep: designing adiabatic pulses for contemporary NMR. J Magn Reson 2001;153:155-177.
2. Scheenen TW, Klomp DW, Wijnen JP, Heerschap A. Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses. Magn Reson Med 2008;59:1-6.
3. Marjanska MG, Auerbach EJ, Valabregue R, Van de Moortele P-F, Adriany G, Garwood M. Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7T: T2 relaxation times and concentrations of cerebral metabolites. NMR Biomed 2012;25:332-339.
4. Oz G, Tkac I. Short-echo, single-shot, full-intensity proton magnetic resonance spectroscopy for neurochemical profiling at 4 T: validation in the cerebellum and brainstem. Magn Reson Med 2011;65:901-910.
5. Michaeli S, Garwood M, Zhu XH, Dela Barre L, Andersen P, Adriany G, Merkle H, Ugurbil K, Chen W. Proton T2 relaxation study of water, N-Acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T. Magn Reson Med 2002;47:629-633.
6. Deelchand DK, Henry P-G, Ugurbil K, Marjanska M. Measurement of transverse relaxation times of J-coupled metabolites in the human visual cortex at 4 T. Magn Reson Med 2012;67:891-897.
7. de Graaf R, Brown P, McIntyre S, Nixon T, Behar K, Rothman D. High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. Magn Reson Med 2006;56:386-394.
8. Marjanska M, Curran GL, Wengenack TM, Henry PG, Bliss RL, Poduslo JF, Jack CR Jr, Ugurbil K, Garwood M. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA 2005;102:11906-11910.
9. Mangia S, Liimatainen T, Garwood M, Tkac I, Henry P-G, Deelchand D, Michaeli S. Frequency offset dependence of adiabatic rotating frame relaxation rate constants: relevance to MRS investigations of metabolite dynamics in vivo. NMR Biomed 2011;24:807-814.
10. Carr HY, Purcell EM. Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys Rev 1954;94:630-638.
11. Allerhand A. Analysis of Carr-Purcell spin-echo NMR experiments on multiple-spin systems. I. The effect of homonuclear coupling. J Chem Phys 1966;44:1-9.
12. Soher BJ, Pattany PM, Matson GB, Maudsley AA. Observation of coupled 1H metabolite resonances at long TE. Magn Reson Med 2005;53:1283-1287.
13. Hennig J, Thiel T, Speck O. Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment. Magn Reson Med 1997;37:816-820.
14. Hancu I, Gillen R, Cowan J, Zimmerman EA. Improved myo-inositol detection through Carr-Purcell PRESS: a tool for more sensitive mild cognitive impairment diagnosis. Magn Reson Med 2011;65:1515-1521.
15. Allerhand A, Thiele E. Analysis of Carr-Purcell spin-echo NMR experiments on multiple-spin systems. II. The effect of chemical exchange. J Chem Phys 1966;45:902-916.
16. Bartha R, Michaeli S, Merkle H, Adriany G, Andersen P, Chen W, Ugurbil K, Garwood M. In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast. Magn Reson Med 2002;47:742-750.
17. Hennig J, Nauerth A, Friedburg H. RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 1986;3:823-833.
18. Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000;43:319-323.
19. Silver MS, Joseph RI, Hoult DI. Highly selective p/2 and p pulse generation. J Magn Reson 1984;59:347-351.
20. Levitt MH, Freeman R, Frenkiel T. Supercycles for broadband heteronuclear decoupling. J Magn Reson 1982;50:157-160.
21. Tkac I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999;41:649-656.
22. Pfeuffer J, Tkac I, Provencher SW, Gruetter R. Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echotime 1H NMR spectra of the rat brain. J Magn Reson 1999;141:104-120.
23. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
24. Henry PG, Marjanska M, Walls JD, Valette J, Gruetter R, Ugurbil K. Proton-observed carbon-edited NMR spectroscopy in strongly coupled second-order spin systems. Magn Reson Med 2006;55:250-257.
25. Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 2000;13:129-153.
26. Mayer D, Dreher W, Leibfritz D, Spielman DM. RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imaging. Magn Reson Med 2007;57:967-971.
27. Pfeuffer J, Tkac I, Gruetter R. Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 2000;20:736-746.
28. Blicharski JS, Kruk D. NMR relaxation spectroscopy: interference effects. Appl Magn Reson 1999;17:367-374.
29. Pervushin K, Riek R, Wider G, Wuthrich K. Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. Proc Natl Acad Sci USA 1997;94:12366-12371.
30. Santyr GE, Henkelman RM, Bronskill MJ. Variation in measured transverse relaxation in tissue resulting from spin locking with the CPMG sequence. J Magn Reson 1988;79:28-44.
31. Michaeli S, Grohn H, Grohn O, Sorce DJ, Kauppinen R, Springer CS Jr, Ugurbil K, Garwood M. Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses. Magn Reson Med 2005;53:823-829.
32. Xin L, Gambarota G, Mlynarik V, Gruetter R. Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T. NMR Biomed 2008;21:396-401.
33. Lei H, Zhang Y, Zhu XH, Chen W. Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T. Magn Reson Med 2003;49:979-984.
34. Kreis R. Quantitative localized 1H MR spectroscopy for clinical use. Prog Nucl Magn Reson Spectrosc 1997;31:155-195.
35. Zhang K, Sejnowski TJ. A universal scaling law between gray matter and white matter of cerebral cortex. Proc Natl Acad Sci USA 2000;97:5621-5626.
36. Deelchand DK, Van de Moortele PF, Adriany G, Iltis I, Andersen P, Strupp JP, Vaughan JT, Ugurbil K, Henry PG. In vivo 1H NMR spectroscopy of the human brain at 9.4 T: initial results. J Magn Reson 2010;206:74-80.
37. Michaeli S, Sorce DJ, Idiyatullin D, Ugurbil K, Garwood M. Transverse relaxation in the rotating frame induced by chemical exchange. J Magn Reson 2004;169:293-299.
38. Mangia S, Liimatainen T, Garwood M, Michaeli S. Rotating frame relaxation during adiabatic pulses vs. conventional spin lock: simulations and experimental results at 4 T. Magn Reson Imaging 2009;27:1074-1087.
39. Mangia S, Garwood M, Tkac I, Ugurbil K, Michaeli S. Probing dynamics of human brain metabolites with 1H MRS by T1rho and T2rho adiabatic relaxations. In Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008. Abstract 693.