메뉴 건너뛰기




Volumn 206, Issue 1, 2010, Pages 74-80

In vivo 1H NMR spectroscopy of the human brain at 9.4 T: Initial results

Author keywords

Brain; Human; Proton NMR spectroscopy; Relaxation times; Ultra high field

Indexed keywords

BIO-CHEMICAL COMPOUNDS; ECHO TIME; FIELD STRENGTHS; H NMR SPECTRA; H NMR SPECTROSCOPY; HIGH FIELD; HUMAN; HUMAN BRAIN; IN-VIVO; INFORMATION CONTENTS; NON-INVASIVE DETECTION; PROTON NMR SPECTROSCOPY; RODENT BRAIN; SIGNAL TO NOISE; SPECTRAL DISPERSIONS; ULTRA-HIGH;

EID: 77955917560     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2010.06.006     Document Type: Article
Times cited : (95)

References (50)
  • 1
    • 0033226834 scopus 로고    scopus 로고
    • Toward an in vivo neurochemical profile: Quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain
    • J. Pfeuffer, I. Tkac, S.W. Provencher, and R. Gruetter Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain J. Magn. Reson. 141 1999 104 120
    • (1999) J. Magn. Reson. , vol.141 , pp. 104-120
    • Pfeuffer, J.1    Tkac, I.2    Provencher, S.W.3    Gruetter, R.4
  • 2
    • 52949130629 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
    • V. Mlynarik, C. Cudalbu, L. Xin, and R. Gruetter 1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: improvements in quantification of the neurochemical profile J. Magn. Reson. 194 2008 163 168
    • (2008) J. Magn. Reson. , vol.194 , pp. 163-168
    • Mlynarik, V.1    Cudalbu, C.2    Xin, L.3    Gruetter, R.4
  • 3
    • 77955919562 scopus 로고    scopus 로고
    • Single voxel MR spectroscopy with echo times below 2 ms at 16.4 T in the rat brain: First in vivo results
    • D.Z. Balla, S.-T. Hong, G. Shajan, R. Pohmann, and K. Ugurbil Single voxel MR spectroscopy with echo times below 2 ms at 16.4 T in the rat brain: first in vivo results Proc. Int. Soc. Mag. Reson. Med. 16 2008 3295
    • (2008) Proc. Int. Soc. Mag. Reson. Med. , vol.16 , pp. 3295
    • Balla, D.Z.1    Hong, S.-T.2    Shajan, G.3    Pohmann, R.4    Ugurbil, K.5
  • 4
    • 0035576811 scopus 로고    scopus 로고
    • Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy
    • I. Tkac, C.D. Keene, J. Pfeuffer, W.C. Low, and R. Gruetter Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy J. Neurosci. Res. 66 2001 891 898
    • (2001) J. Neurosci. Res. , vol.66 , pp. 891-898
    • Tkac, I.1    Keene, C.D.2    Pfeuffer, J.3    Low, W.C.4    Gruetter, R.5
  • 5
    • 0034777052 scopus 로고    scopus 로고
    • Multivoxel 3D proton spectroscopy in the brain at 1.5 versus 3.0 T: Signal-to-noise ratio and resolution comparison
    • O. Gonen, S. Gruber, B.S. Li, V. Mlynarik, and E. Moser Multivoxel 3D proton spectroscopy in the brain at 1.5 versus 3.0 T: signal-to-noise ratio and resolution comparison AJNR Am. J. Neuroradiol. 22 2001 1727 1731
    • (2001) AJNR Am. J. Neuroradiol. , vol.22 , pp. 1727-1731
    • Gonen, O.1    Gruber, S.2    Li, B.S.3    Mlynarik, V.4    Moser, E.5
  • 6
    • 0033865461 scopus 로고    scopus 로고
    • Comparison of the quantification precision of human short echo time (1)H spectroscopy at 1.5 and 4.0 Tesla
    • R. Bartha, D.J. Drost, R.S. Menon, and P.C. Williamson Comparison of the quantification precision of human short echo time (1)H spectroscopy at 1.5 and 4.0 Tesla Magn. Reson. Med. 44 2000 185 192
    • (2000) Magn. Reson. Med. , vol.44 , pp. 185-192
    • Bartha, R.1    Drost, D.J.2    Menon, R.S.3    Williamson, P.C.4
  • 7
    • 67049169082 scopus 로고    scopus 로고
    • MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3 T and 7 T
    • R. Mekle, V. Mlynárik, G. Gambarota, M. Hergt, G. Krueger, and R. Gruetter MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3 T and 7 T Magn. Reson. Med. 61 2009 1279 1285
    • (2009) Magn. Reson. Med. , vol.61 , pp. 1279-1285
    • Mekle, R.1    Mlynárik, V.2    Gambarota, G.3    Hergt, M.4    Krueger, G.5    Gruetter, R.6
  • 8
    • 70349613203 scopus 로고    scopus 로고
    • In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4 T vs. 7 T
    • I. Tkac, G. Oz, G. Adriany, K. Ugurbil, and R. Gruetter In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4 T vs. 7 T Magn. Reson. Med. 62 2009 868 879
    • (2009) Magn. Reson. Med. , vol.62 , pp. 868-879
    • Tkac, I.1    Oz, G.2    Adriany, G.3    Ugurbil, K.4    Gruetter, R.5
  • 10
    • 33845239492 scopus 로고    scopus 로고
    • Signal-to-noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo-planar spectroscopic imaging
    • R. Otazo, B. Mueller, K. Ugurbil, L. Wald, and S. Posse Signal-to-noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo-planar spectroscopic imaging Magn. Reson. Med. 56 2006 1200 1210
    • (2006) Magn. Reson. Med. , vol.56 , pp. 1200-1210
    • Otazo, R.1    Mueller, B.2    Ugurbil, K.3    Wald, L.4    Posse, S.5
  • 12
    • 35848950962 scopus 로고    scopus 로고
    • Safety of human MRI at static fields above the FDA 8 T guideline: Sodium imaging at 9.4 T does not affect vital signs or cognitive ability
    • I.C. Atkinson, L. Renteria, H. Burd, N.H. Pliskin, and K.R. Thulborn Safety of human MRI at static fields above the FDA 8 T guideline: sodium imaging at 9.4 T does not affect vital signs or cognitive ability J. Magn. Reson. Imag. 26 2007 1222 1227
    • (2007) J. Magn. Reson. Imag. , vol.26 , pp. 1222-1227
    • Atkinson, I.C.1    Renteria, L.2    Burd, H.3    Pliskin, N.H.4    Thulborn, K.R.5
  • 16
    • 38949112082 scopus 로고    scopus 로고
    • Local B1+ shimming for prostate imaging with transceiver arrays at 7 T based on subject-dependent transmit phase measurements
    • G.J. Metzger, C. Snyder, C. Akgun, T. Vaughan, K. Ugurbil, and P.F. Van de Moortele Local B1+ shimming for prostate imaging with transceiver arrays at 7 T based on subject-dependent transmit phase measurements Magn. Reson. Med. 59 2008 396 409
    • (2008) Magn. Reson. Med. , vol.59 , pp. 396-409
    • Metzger, G.J.1    Snyder, C.2    Akgun, C.3    Vaughan, T.4    Ugurbil, K.5    Van De Moortele, P.F.6
  • 18
    • 0342948677 scopus 로고    scopus 로고
    • Field mapping without reference scan using asymmetric echo-planar techniques
    • R. Gruetter, and I. Tkac Field mapping without reference scan using asymmetric echo-planar techniques Magn. Reson. Med. 43 2000 319 323
    • (2000) Magn. Reson. Med. , vol.43 , pp. 319-323
    • Gruetter, R.1    Tkac, I.2
  • 19
    • 0032588957 scopus 로고    scopus 로고
    • In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time
    • I. Tkac, Z. Starcuk, I.Y. Choi, and R. Gruetter In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time Magn. Reson. Med. 41 1999 649 656
    • (1999) Magn. Reson. Med. , vol.41 , pp. 649-656
    • Tkac, I.1    Starcuk, Z.2    Choi, I.Y.3    Gruetter, R.4
  • 20
    • 0035742326 scopus 로고    scopus 로고
    • The return of the frequency sweep: Designing adiabatic pulses for contemporary NMR
    • M. Garwood, and L. DelaBarre The return of the frequency sweep: designing adiabatic pulses for contemporary NMR J. Magn. Reson. 153 2001 155 177
    • (2001) J. Magn. Reson. , vol.153 , pp. 155-177
    • Garwood, M.1    Delabarre, L.2
  • 22
    • 0031425055 scopus 로고    scopus 로고
    • Theory and application of array coils in MR spectroscopy
    • S.M. Wright, and L.L. Wald Theory and application of array coils in MR spectroscopy NMR Biomed. 10 1997 394 410
    • (1997) NMR Biomed. , vol.10 , pp. 394-410
    • Wright, S.M.1    Wald, L.L.2
  • 23
    • 0034099574 scopus 로고    scopus 로고
    • Proton NMR chemical shifts and coupling constants for brain metabolites
    • V. Govindaraju, K. Young, and A.A. Maudsley Proton NMR chemical shifts and coupling constants for brain metabolites NMR Biomed. 13 2000 129 153
    • (2000) NMR Biomed. , vol.13 , pp. 129-153
    • Govindaraju, V.1    Young, K.2    Maudsley, A.A.3
  • 24
    • 0025760609 scopus 로고
    • Species differences in cerebral taurine concentrations correlate with brain water content
    • M. Puka, K. Sundell, J.W. Lazarewicz, and A. Lehmann Species differences in cerebral taurine concentrations correlate with brain water content Brain Res. 548 1991 267 272
    • (1991) Brain Res. , vol.548 , pp. 267-272
    • Puka, M.1    Sundell, K.2    Lazarewicz, J.W.3    Lehmann, A.4
  • 26
    • 26844563950 scopus 로고    scopus 로고
    • Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects
    • R. Kreis, J. Slotboom, L. Hofmann, and C. Boesch Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects Magn. Reson. Med. 54 2005 761 768
    • (2005) Magn. Reson. Med. , vol.54 , pp. 761-768
    • Kreis, R.1    Slotboom, J.2    Hofmann, L.3    Boesch, C.4
  • 27
    • 0036091417 scopus 로고    scopus 로고
    • Relaxation times of choline, creatine and N-acetyl aspartate in human cerebral white matter at 1.5 T
    • D. Rutgers, and J. van der Grond Relaxation times of choline, creatine and N-acetyl aspartate in human cerebral white matter at 1.5 T NMR Biomed. 15 2002 215 221
    • (2002) NMR Biomed. , vol.15 , pp. 215-221
    • Rutgers, D.1    Van Der Grond, J.2
  • 28
    • 0024493728 scopus 로고
    • Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo
    • DOI 10.1002/mrm.1910090110
    • J. Frahm, H. Bruhn, M.L. Gyngell, K.D. Merboldt, W. Hanicke, and R. Sauter Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo Magn. Reson. Med. 9 1989 79 93 (Pubitemid 19044561)
    • (1989) Magnetic Resonance in Medicine , vol.9 , Issue.1 , pp. 79-93
    • Frahm, J.1    Bruhn, H.2    Gyngell, M.L.3    Merboldt, K.D.4    Hanicke, W.5    Sauter, R.6
  • 29
    • 0345167988 scopus 로고    scopus 로고
    • Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla
    • T. Ethofer, I. Mader, U. Seeger, G. Helms, M. Erb, W. Grodd, A. Ludolph, and U. Klose Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla Magn. Reson. Med. 50 2003 1296 1301
    • (2003) Magn. Reson. Med. , vol.50 , pp. 1296-1301
    • Ethofer, T.1    Mader, I.2    Seeger, U.3    Helms, G.4    Erb, M.5    Grodd, W.6    Ludolph, A.7    Klose, U.8
  • 30
    • 0344286501 scopus 로고    scopus 로고
    • Localized proton MRS of the human hippocampus: Metabolite concentrations and relaxation times. Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo
    • C.G. Choi, J. Frahm, H. Bruhn, M.L. Gyngell, K.D. Merboldt, W. Hanicke, and R. Sauter Localized proton MRS of the human hippocampus: metabolite concentrations and relaxation times. Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo Magn. Reson. Med. 41 1999 204 207
    • (1999) Magn. Reson. Med. , vol.41 , pp. 204-207
    • Choi, C.G.1    Frahm, J.2    Bruhn, H.3    Gyngell, M.L.4    Merboldt, K.D.5    Hanicke, W.6    Sauter, R.7
  • 31
    • 0034875929 scopus 로고    scopus 로고
    • Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla
    • V. Mlynarik, S. Gruber, and E. Moser Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla NMR Biomed. 14 2001 325 331
    • (2001) NMR Biomed. , vol.14 , pp. 325-331
    • Mlynarik, V.1    Gruber, S.2    Moser, E.3
  • 32
    • 18744407587 scopus 로고    scopus 로고
    • Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
    • R. Srinivasan, N. Sailasuta, R. Hurd, S. Nelson, and D. Pelletier Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T Brain 128 2005 1016 1025
    • (2005) Brain , vol.128 , pp. 1016-1025
    • Srinivasan, R.1    Sailasuta, N.2    Hurd, R.3    Nelson, S.4    Pelletier, D.5
  • 33
  • 36
    • 14844293104 scopus 로고    scopus 로고
    • 2 relaxation of cerebral metabolites of normal human brain over large TE range
    • 2 relaxation of cerebral metabolites of normal human brain over large TE range NMR Biomed. 18 2005 14 18
    • (2005) NMR Biomed. , vol.18 , pp. 14-18
    • Brief, E.E.1    Whittall, K.P.2    Li, D.K.3    MacKay, A.L.4
  • 37
    • 0035033720 scopus 로고    scopus 로고
    • Single-voxel proton MRS of the human brain at 1.5 T and 3.0 T
    • P.B. Barker, D.O. Hearshen, and M.D. Boska Single-voxel proton MRS of the human brain at 1.5 T and 3.0 T Magn. Reson. Med. 45 2001 765 769
    • (2001) Magn. Reson. Med. , vol.45 , pp. 765-769
    • Barker, P.B.1    Hearshen, D.O.2    Boska, M.D.3
  • 39
    • 1842504496 scopus 로고    scopus 로고
    • Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla
    • F. Schubert, J. Gallinat, F. Seifert, and H. Rinneberg Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla Neuroimage 21 2004 1762 1771
    • (2004) Neuroimage , vol.21 , pp. 1762-1771
    • Schubert, F.1    Gallinat, J.2    Seifert, F.3    Rinneberg, H.4
  • 41
    • 0029884561 scopus 로고    scopus 로고
    • Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla
    • R. Gruetter, M. Garwood, K. Ugurbil, and E.R. Seaquist Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla Magn. Reson. Med. 36 1996 1 6
    • (1996) Magn. Reson. Med. , vol.36 , pp. 1-6
    • Gruetter, R.1    Garwood, M.2    Ugurbil, K.3    Seaquist, E.R.4
  • 42
    • 41549098677 scopus 로고    scopus 로고
    • Rat brain metabolite relaxation time estimates using magnetic resonance spectroscopy at two different field strengths
    • C. Cudalbu, A. Rengle, O. Beuf, and S. Cavassila Rat brain metabolite relaxation time estimates using magnetic resonance spectroscopy at two different field strengths C.R. Chim. 11 2008 442 447
    • (2008) C.R. Chim. , vol.11 , pp. 442-447
    • Cudalbu, C.1    Rengle, A.2    Beuf, O.3    Cavassila, S.4
  • 45
  • 46
    • 0038778617 scopus 로고    scopus 로고
    • 2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T
    • 2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T Magn. Reson. Med. 49 2003 979 984
    • (2003) Magn. Reson. Med. , vol.49 , pp. 979-984
    • Lei, H.1    Zhang, Y.2    Zhu, X.H.3    Chen, W.4
  • 48
    • 41849102763 scopus 로고    scopus 로고
    • Towards 1H-MRSI of the human brain at 7 T with slice-selective adiabatic refocusing pulses
    • T.W. Scheenen, A. Heerschap, and D.W. Klomp Towards 1H-MRSI of the human brain at 7 T with slice-selective adiabatic refocusing pulses Magma 21 2008 95 101
    • (2008) Magma , vol.21 , pp. 95-101
    • Scheenen, T.W.1    Heerschap, A.2    Klomp, D.W.3
  • 50
    • 33846078031 scopus 로고    scopus 로고
    • Actual flip-angle imaging in the pulsed steady state: A method for rapid three-dimensional mapping of the transmitted radiofrequency field
    • V.L. Yarnykh Actual flip-angle imaging in the pulsed steady state: a method for rapid three-dimensional mapping of the transmitted radiofrequency field Magn. Reson. Med. 57 2007 192 200
    • (2007) Magn. Reson. Med. , vol.57 , pp. 192-200
    • Yarnykh, V.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.