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Volumn 6, Issue 11, 2014, Pages 1221-1235

Immunotherapy and lung cancer: Current developments and novel targeted therapies

Author keywords

checkpoint inhibitors; immunotherapies; lung cancer; nivolumab; tremelimumab; tumor vaccines

Indexed keywords

CANCER ANTIBODY; DENDRITIC CELL VACCINE; IMMUNOMODULATING AGENT; IPILIMUMAB; LIRILUMAB; MELANOMA ANTIGEN 3; NIVOLUMAB; PEMBROLIZUMAB; RECOMBINANT CYTOKINE; TECEMOTIDE; TG 4010; TICILIMUMAB; TUMOR CELL VACCINE; CANCER VACCINE; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

EID: 84919832561     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.82     Document Type: Review
Times cited : (46)

References (72)
  • 1
    • 84919821735 scopus 로고    scopus 로고
    • GLOBOCAN. http://globocan.iarc.fr/Pages/fact-sheets-cancer.aspx
    • Globocan
  • 3
    • 44249086425 scopus 로고    scopus 로고
    • Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship
    • Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83(5), 584-594 (2008
    • (2008) Mayo Clin. Proc , vol.83 , Issue.5 , pp. 584-594
    • Molina, J.R.1    Yang, P.2    Cassivi, S.D.3    Schild, S.E.4    Adjei, A.A.5
  • 5
    • 49049089802 scopus 로고    scopus 로고
    • Phase iii study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced stage non-small cell lung cancer
    • Scagliotti G, Parikh P, Von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced stage non-small cell lung cancer. J. Clin. Oncol. 26, 3543-3551 (2008
    • (2008) J. Clin. Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.1    Parikh, P.2    Von Pawel, J.3
  • 6
    • 0346238665 scopus 로고    scopus 로고
    • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
    • International Adjuvant Lung Cancer Trial Collaborative Group
    • Arriagada R, Bergman B, Dunant A, et al. International Adjuvant Lung Cancer Trial Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N. Engl. J. Med. 350(4), 351-360 (2004
    • (2004) N. Engl. J. Med , vol.350 , Issue.4 , pp. 351-360
    • Arriagada, R.1    Bergman, B.2    Dunant, A.3
  • 7
    • 69349088824 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor and kras mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
    • Jackman DM, Miller VA, Cioffredi LA, et al. Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials. Clin. Cancer Res. 15(16), 5267-5273 (2009
    • (2009) Clin. Cancer Res , vol.15 , Issue.16 , pp. 5267-5273
    • Jackman, D.M.1    Miller, V.A.2    Cioffredi, L.A.3
  • 8
    • 84871574719 scopus 로고    scopus 로고
    • Beyond the standard of care: A review of novel immunotherapy trials for the treatment of lung cancer
    • Hall RD, Gray JE, Chiappori AA. Beyond the standard of care: A review of novel immunotherapy trials for the treatment of lung cancer. Cancer Control 20(1), 22-31 (2013
    • (2013) Cancer Control , vol.20 , Issue.1 , pp. 22-31
    • Hall, R.D.1    Gray, J.E.2    Chiappori, A.A.3
  • 9
    • 84888813447 scopus 로고    scopus 로고
    • Current clinical immunotherapy targets in advanced non-small cell lung cancer (nsclc
    • McCarthy F, Roshani R, Steele J, Hagemann T. Current clinical immunotherapy targets in advanced non-small cell lung cancer (NSCLC). J. Leukoc. Biol. 94(6), 1201-1206 (2013
    • (2013) J. Leukoc. Biol , vol.94 , Issue.6 , pp. 1201-1206
    • McCarthy, F.1    Roshani, R.2    Steele, J.3    Hagemann, T.4
  • 10
    • 84880099830 scopus 로고    scopus 로고
    • Locally advanced lung cancer: An optimal setting for vaccines and other immunotherapies
    • Iyengar P, Gerber DE. Locally advanced lung cancer: An optimal setting for vaccines and other immunotherapies. Cancer J. 19(3), 247-262 (2013
    • (2013) Cancer J. , vol.19 , Issue.3 , pp. 247-262
    • Iyengar, P.1    Gerber, D.E.2
  • 11
    • 84946221495 scopus 로고    scopus 로고
    • Exploring novel immune-related toxicities and endpoints with immune-checkpoint inhibitors in non-small cell lung cancer
    • Chow LM. Exploring novel immune-related toxicities and endpoints with immune-checkpoint inhibitors in non-small cell lung cancer. Am. Soc. Clin. Oncol. Educ. Book 280-285 (2013
    • (2013) Am. Soc. Clin. Oncol. Educ. Book , pp. 280-285
    • Chow, L.M.1
  • 12
    • 84877149232 scopus 로고    scopus 로고
    • Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small cell lung cancer
    • Zielinski C, Knapp S, Mascaux C, Hirsch F. Rationale for targeting the immune system through checkpoint molecule blockade in the treatment of non-small cell lung cancer. Ann. Oncol. 24(5), 1170-1179 (2013
    • (2013) Ann. Oncol , vol.24 , Issue.5 , pp. 1170-1179
    • Zielinski, C.1    Knapp, S.2    Mascaux, C.3    Hirsch, F.4
  • 13
    • 84894054771 scopus 로고    scopus 로고
    • Immunotherapy for lung cancer: Ongoing clinical trials
    • Declerck S, Vansteenkiste J. Immunotherapy for lung cancer: Ongoing clinical trials. Future Oncol. 10(1), 91-105 (2014
    • (2014) Future Oncol , vol.10 , Issue.1 , pp. 91-105
    • Declerck, S.1    Vansteenkiste, J.2
  • 14
    • 84876942195 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic t cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer
    • Aerts JG, Hegmans JP. Tumor-specific cytotoxic T cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer. Cancer Res. 15, 73(8), 2381-2388 (2013
    • (2013) Cancer Res , vol.1573 , Issue.8 , pp. 2381-2388
    • Aerts, J.G.1    Hegmans, J.P.2
  • 15
    • 80255134621 scopus 로고    scopus 로고
    • Active-specific immunotherapy for non-small cell lung cancer
    • Winter H, van Den Engel NK, Rusan M, et al. Active-specific immunotherapy for non-small cell lung cancer. J. Thorac. Dis. 3(2), 105-114 (2011
    • (2011) J. Thorac. Dis , vol.3 , Issue.2 , pp. 105-114
    • Winter, H.1    Van Den Engel, N.K.2    Rusan, M.3
  • 16
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive disease small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive disease small-cell lung cancer: Results from a randomized, double-blind, multicenter Phase 2 trial. Ann. Oncol. 24(1), 75-83 (2013
    • (2013) Ann. Oncol , vol.24 , Issue.1 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 17
    • 84886944447 scopus 로고    scopus 로고
    • Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
    • Chang S, Lin X, Higashikubo R. Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy. Oncoimmunology 2(3), e23563 (2013
    • (2013) Oncoimmunology , vol.2 , Issue.3 , pp. e23563
    • Chang, S.1    Lin, X.2    Higashikubo, R.3
  • 18
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory cd4(+) cd25(+) t cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo EY, Chu CS, Goletz TJ, et al. Regulatory CD4(+) CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61, 4766-4772 (2001
    • (2001) Cancer Res , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3
  • 19
    • 84888347627 scopus 로고    scopus 로고
    • Immunotherapy in lc: B7-bombers and other new developments
    • Creelan BC, Antonia SJ. Immunotherapy in LC: B7-bombers and other new developments. Semin. Respir. Crit. Care Med. 34(6), 810-821 (2013
    • (2013) Semin. Respir. Crit. Care Med , vol.34 , Issue.6 , pp. 810-821
    • Creelan, B.C.1    Antonia, S.J.2
  • 20
    • 67349186983 scopus 로고    scopus 로고
    • How cigarette smoke skews immune responses to promote infection, lung disease and cancer
    • Stämpfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat. Rev. Immunol. 9(5), 377-384 (2009
    • (2009) Nat. Rev. Immunol , vol.9 , Issue.5 , pp. 377-384
    • Stämpfli, M.R.1    Anderson, G.P.2
  • 21
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N. Engl. J. Med. 366(10), 925-931 (2012
    • (2012) N. Engl. J. Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 22
    • 84883041223 scopus 로고    scopus 로고
    • Immunotherapy and the concept of a clinical cure
    • Eggermont AMM, Kroemer G, Zitvogel L, et al. Immunotherapy and the concept of a clinical cure. Eur. J. Cancer 49, 2965-2967 (2013
    • (2013) Eur. J. Cancer , vol.49 , pp. 2965-2967
    • Eggermont, A.M.M.1    Kroemer, G.2    Zitvogel, L.3
  • 23
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage iiib/iv non-small-cell lc: Results from a randomized, double-blind, multicenter phase ii study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell LC: Results from a randomized, double-blind, multicenter Phase II study. J. Clin. Oncol. 30(17), 2046-2054 (2012
    • (2012) J. Clin. Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 24
    • 84919828451 scopus 로고    scopus 로고
    • Randomized phase ii clinical trial comparing tremelimumab (cp-675 206) with best supportive care (bsc) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (nsclc
    • Zatloukal P, Heo DS, Park K, et al. Randomized Phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) J. Clin. Oncol. 30(17), 2046-2054 (2012
    • (2012) J Clin. Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Zatloukal, P.1    Heo, D.S.2    Park, K.3
  • 25
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-pd-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 26
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-Agent anti-programmed death-1 (mdx-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-Agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010
    • (2010) J. Clin. Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 27
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-pd-l1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012
    • (2012) N. Engl. J. Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 28
    • 84887262315 scopus 로고    scopus 로고
    • A study of mpdl3280a, an engineered pd-l1 antibody in patients with locally advanced or metastatic tumors
    • Suppl. Abstract
    • Herbst RS, Gordon MS, Fine GD, et al. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J. Clin. Oncol. 31(Suppl.) Abstract 3000 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 3000
    • Herbst, R.S.1    Gordon, M.S.2    Fine, G.D.3
  • 29
    • 84880755387 scopus 로고    scopus 로고
    • Adjuvant mage-A3 immunotherapy in resected non-small-cell lung cancer: Phase ii randomized study results
    • Vansteenkiste J, Zielinski M, Linder A, et al. Adjuvant MAGE-A3 immunotherapy in resected non-small-cell lung cancer: Phase II randomized study results. J. Clin. Oncol. 31(19), 2396-2403 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.19 , pp. 2396-2403
    • Vansteenkiste, J.1    Zielinski, M.2    Linder, A.3
  • 30
    • 80054742888 scopus 로고    scopus 로고
    • Updated survival analysis in patients with stage iiib or iv non-small-cell lung cancer receiving blp25 liposome vaccine (l-blp25): Phase iib randomized, multicenter, open-label trial
    • Butts C, Maksymiuk A, Goss G, et al. Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): Phase IIB randomized, multicenter, open-label trial. J. Cancer Res. Clin. Oncol. 137(9), 1337-1342 (2011
    • (2011) J. Cancer Res. Clin. Oncol , vol.137 , Issue.9 , pp. 1337-1342
    • Butts, C.1    Maksymiuk, A.2    Goss, G.3
  • 31
    • 84891373760 scopus 로고    scopus 로고
    • Tecemotide (l-blp25) versus placebo after chemoradiotherapy for stage iii non-small-cell lung cancer (start): A randomised, double-blind, phase 3 trial
    • Butts C, Socinski MA, Mitchell PL, et al. Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): A randomised, double-blind, Phase 3 trial. Lancet Oncol. 15(1), 59-68 (2014
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 59-68
    • Butts, C.1    Socinski, M.A.2    Mitchell, P.L.3
  • 32
    • 50349090322 scopus 로고    scopus 로고
    • A phase ii study of tg4010 (mva-muc1-il2) in association with chemotherapy in patients with stage iii/iv non-small cell lung cancer
    • Ramlau R, Quoix E, Rolski J, et al. A Phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J. Thorac. Oncol. 3(7), 735-744 (2008
    • (2008) J. Thorac. Oncol , vol.3 , Issue.7 , pp. 735-744
    • Ramlau, R.1    Quoix, E.2    Rolski, J.3
  • 33
    • 81255127285 scopus 로고    scopus 로고
    • Therapeutic vaccination with tg4010 and first-line chemotherapy in advanced non-small-cell lung cancer: A controlled phase 2b trial
    • Quoix E, Ramlau R, Westeel V, et al. Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: A controlled Phase 2B trial. Lancet Oncol. 12(12), 1125-1133 (2011
    • (2011) Lancet Oncol , vol.12 , Issue.12 , pp. 1125-1133
    • Quoix, E.1    Ramlau, R.2    Westeel, V.3
  • 34
    • 41149159650 scopus 로고    scopus 로고
    • Phase ii randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer
    • Neninger Vinageras, E, de la Torre A, Osorio Rodríguez M, et al. Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer. J. Clin. Oncol. 26(9), 1452-1458 (2008
    • (2008) J. Clin. Oncol , vol.26 , Issue.9 , pp. 1452-1458
    • Neninger Vinageras, E.1    De La Torre, A.2    Osorio Rodríguez, M.3
  • 35
    • 27244446896 scopus 로고    scopus 로고
    • Phase iii study of adjuvant vaccination with bec2/bacille calmette-guerin in responding patients with limited-disease small-cell lung cancer (european organisation for research and treatment of cancer 08971-08971b; silva study
    • Giaccone G, Debruyne C, Felip E, et al. Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J. Clin. Oncol. 23(28), 6854-6864 (2005
    • (2005) J. Clin. Oncol , vol.23 , Issue.28 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 36
    • 84904386095 scopus 로고    scopus 로고
    • A randomized, multicenter, placebo-controlled clinical trial of racotumomab-Alum vaccine as switch maintenance therapy in advanced non-small-cell-lung cancer patients
    • Alfonso S, Valdes-Zayas A, Santiesteban ER, et al. A randomized, multicenter, placebo-controlled clinical trial of racotumomab-Alum vaccine as switch maintenance therapy in advanced non-small-cell-lung cancer patients. Clin. Cancer Res. 20(14), 3660-3671 (2014
    • (2014) Clin. Cancer Res , vol.20 , Issue.14 , pp. 3660-3671
    • Alfonso, S.1    Valdes-Zayas, A.2    Santiesteban, E.R.3
  • 37
    • 33750586798 scopus 로고    scopus 로고
    • Phase ii study of belagenpumatucel-l, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
    • Nemunaitis J, Dillman RO, Schwarzenberger PO, et al. Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J. Clin. Oncol. 24(29), 4721-4730 (2006)
    • (2006) J. Clin. Oncol , vol.24 , Issue.29 , pp. 4721-4730
    • Nemunaitis, J.1    Dillman, R.O.2    Schwarzenberger, P.O.3
  • 38
    • 79958111407 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase ii study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer
    • Digumarti R, Wang Y, Raman G, et al. A randomized, double-blind, placebo-controlled, Phase II study of oral talactoferrin in combination with carboplatin and paclitaxel in previously untreated locally advanced or metastatic non-small cell lung cancer. J. Thorac. Oncol. 6(6), 1098-1103 (2011
    • (2011) J. Thorac. Oncol , vol.6 , Issue.6 , pp. 1098-1103
    • Digumarti, R.1    Wang, Y.2    Raman, G.3
  • 39
    • 80755143443 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase ii study of single-Agent oral talactoferrin in patients with locally advanced or metastatic non-small-cell lung cancer that progressed after chemotherapy
    • Parikh PM, Vaid A, Advani SH, et al. Randomized, double-blind, placebo-controlled Phase II study of single-Agent oral talactoferrin in patients with locally advanced or metastatic non-small-cell lung cancer that progressed after chemotherapy. J. Clin. Oncol. 29(31), 4129-4136 (2011
    • (2011) J. Clin. Oncol , vol.29 , Issue.31 , pp. 4129-4136
    • Parikh, P.M.1    Vaid, A.2    Advani, S.H.3
  • 40
    • 84887121328 scopus 로고    scopus 로고
    • Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (fortis-m trial
    • Ramalingam S, Crawford J, Chang A, et al. Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (FORTIS-M trial). Ann. Oncol. 24(11), 2875-2880 (2013
    • (2013) Ann. Oncol , vol.24 , Issue.11 , pp. 2875-2880
    • Ramalingam, S.1    Crawford, J.2    Chang, A.3
  • 41
    • 66149150970 scopus 로고    scopus 로고
    • Second-line treatment of non small cell lung cancer by biweekly gemcitabine and docetaxel +/- granulocyte-macrophage colony stimulating factor and low dose aldesleukine
    • Correale P, Tindara Miano S, Remondo C, et al. Second-line treatment of non small cell lung cancer by biweekly gemcitabine and docetaxel +/- granulocyte-macrophage colony stimulating factor and low dose aldesleukine. Cancer Biol. Ther. 8(6), 497-502 (2009
    • (2009) Cancer Biol. Ther , vol.8 , Issue.6 , pp. 497-502
    • Correale, P.1    Tindara Miano, S.2    Remondo, C.3
  • 42
    • 79960858227 scopus 로고    scopus 로고
    • Chemotherapy with or without low-dose interleukin-2 in advanced non-small cell lung cancer: Results from a phase iii randomized multicentric trial
    • Ridolfi L, Bertetto O, Santo A, et al. Chemotherapy with or without low-dose interleukin-2 in advanced non-small cell lung cancer: Results from a Phase III randomized multicentric trial. Int. J. Oncol. 39(4), 1011-1017 (2011
    • (2011) Int. J. Oncol , vol.39 , Issue.4 , pp. 1011-1017
    • Ridolfi, L.1    Bertetto, O.2    Santo, A.3
  • 43
    • 42549091038 scopus 로고    scopus 로고
    • Neuroimmunomodulation in medical oncology: Application of psychoneuroimmunology with subcutaneous low-dose il-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors
    • Lissoni P, Brivio F, Fumagalli L, et al. Neuroimmunomodulation in medical oncology: Application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors. Anticancer Res. 28(2B), 1377-1381 (2008
    • (2008) Anticancer Res , vol.28 , Issue.2 , pp. 1377-1381
    • Lissoni, P.1    Brivio, F.2    Fumagalli, L.3
  • 44
    • 84902130427 scopus 로고    scopus 로고
    • Role of immunotherapy in the treatment of advanced non-small-cell lung cancer
    • Rijavec E, Genova C, Alama A, et al. Role of immunotherapy in the treatment of advanced non-small-cell lung cancer. Future Oncol. 10(1), 79-90 (2014
    • (2014) Future Oncol , vol.10 , Issue.1 , pp. 79-90
    • Rijavec, E.1    Genova, C.2    Alama, A.3
  • 45
    • 84868029449 scopus 로고    scopus 로고
    • Hormone and cytokine circadian alteration in non-small cell lc patients
    • Mazzoccoli G, Sothern RB, Francavilla M, et al. Hormone and cytokine circadian alteration in non-small cell LC patients. Int. J. Immunopathol. Pharmacol. 25(3), 691-702 (2012
    • (2012) Int. J. Immunopathol. Pharmacol , vol.25 , Issue.3 , pp. 691-702
    • Mazzoccoli, G.1    Sothern, R.B.2    Francavilla, M.3
  • 46
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010
    • (2010) N. Engl. J. Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'day, S.J.2    McDermott, D.F.3
  • 47
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011
    • (2011) N. Engl. J. Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 48
    • 84883450601 scopus 로고    scopus 로고
    • Synergy between chemotherapeutic agents and ctla-4 blockade in preclinical tumor models
    • Jure-Kunkel M, Masters G, Girit E, et al. Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models. Cancer Immunol. Immunother. 62, 1533-1545 (2013
    • (2013) Cancer Immunol. Immunother , vol.62 , pp. 1533-1545
    • Jure-Kunkel, M.1    Masters, G.2    Girit, E.3
  • 49
    • 77955469989 scopus 로고    scopus 로고
    • Antitumor activity of cytotoxic t-lymphocyte antigen-4 blockade alone or combined with paclitaxel, etoposide or gemcitabine in murine models
    • Masters G, Barreto L, Girit E, et al. Antitumor activity of cytotoxic T-lymphocyte antigen-4 blockade alone or combined with paclitaxel, etoposide or gemcitabine in murine models. J. Immunother. 32, 994 (2009
    • (2009) J. Immunother , vol.32 , pp. 994
    • Masters, G.1    Barreto, L.2    Girit, E.3
  • 50
    • 84871196652 scopus 로고    scopus 로고
    • Phase i study of mk-3475 (anti-pd-1 monoclonal antibody in patients with advanced solid tumors
    • Suppl.), Abstract
    • Patnaik A, Kang SP, Tolcher AW, et al. Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. J. Clin. Oncol. 30(Suppl.), Abstract 2512 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 2512
    • Patnaik, A.1    Kang, S.P.2    Tolcher, A.W.3
  • 51
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of mpdl3280a, an engineered pd-l1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (nsclc 2013 asco annual meeting
    • Suppl.) Abstract
    • Spigel Dr, Gettinger SN, Horn L, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). 2013 ASCO Annual Meeting, J. Clin. Oncol. 31(Suppl.) Abstract 8008 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 8008
    • Spigel, D.R.1    Gettinger, S.N.2    Horn, L.3
  • 52
    • 84896907483 scopus 로고    scopus 로고
    • Recent advances in immunotherapy for non-small-cell lung cancer
    • Suzuki H, Owada Y, Watanabe Y, et al. Recent advances in immunotherapy for non-small-cell lung cancer. Hum. Vaccin. Immunother. 10(2), 352-357 (2013
    • (2013) Hum. Vaccin. Immunother , vol.10 , Issue.2 , pp. 352-357
    • Suzuki, H.1    Owada, Y.2    Watanabe, Y.3
  • 53
    • 84919822831 scopus 로고    scopus 로고
    • Press release
    • GlaxoSmithKline. Press release (2014). www.gsk.com/media/press-releases/2014/update-on-phase- III-clinical-Trial-of-investigational-MAGE-A3
    • (2014) GlaxoSmithKline
  • 54
    • 27244449289 scopus 로고    scopus 로고
    • Randomized phase iib trial of blp25 liposome vaccine in stage iiib and iv non-small-cell lung cancer
    • Butts C, Murray N, Maksymiuk A, et al. Randomized Phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J. Clin. Oncol. 23(27), 6674-6681 (2005
    • (2005) J. Clin. Oncol , vol.23 , Issue.27 , pp. 6674-6681
    • Butts, C.1    Murray, N.2    Maksymiuk, A.3
  • 55
    • 0032979212 scopus 로고    scopus 로고
    • Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody bec2 plus bacillus calmette-guérin
    • Grant SC, Kris MG, Houghton AN, Chapman PB. Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin. Clin. Cancer Res. 5(6), 1319-1323 (1999
    • (1999) Clin. Cancer Res , vol.5 , Issue.6 , pp. 1319-1323
    • Grant, S.C.1    Kris, M.G.2    Houghton, A.N.3    Chapman, P.B.4
  • 56
    • 33646776056 scopus 로고    scopus 로고
    • Phase 1/2 trial of autologous tumor mixed with an allogeneic gvax vaccine in advanced-stage non-small-cell lung cancer
    • Nemunaitis J, Jahan T, Ross H, et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer. Cancer Gene Ther. 13(6), 555-562 (2006
    • (2006) Cancer Gene Ther , vol.13 , Issue.6 , pp. 555-562
    • Nemunaitis, J.1    Jahan, T.2    Ross, H.3
  • 57
    • 84880855003 scopus 로고    scopus 로고
    • Immunological markers of anti-Tumor dendritic cells vaccine efficiency in patients with non-small cell lung cancer
    • Skachkova OV, Khranovska NM, Gorbach OI, Svergun NM, Sydor RI, Nikulina VV. Immunological markers of anti-Tumor dendritic cells vaccine efficiency in patients with non-small cell lung cancer. Exp. Oncol. 35(2), 109-113 (2013
    • (2013) Exp. Oncol , vol.35 , Issue.2 , pp. 109-113
    • Skachkova, O.V.1    Khranovska, N.M.2    Gorbach, O.I.3    Svergun, N.M.4    Sydor, R.I.5    Nikulina, V.V.6
  • 59
    • 80051734670 scopus 로고    scopus 로고
    • Synergistic effect of ch-296 and interferon gamma on cytokine-induced killer cells expansion for patients with advanced-stage malignant solid tumors
    • Yu J, Ren X, Li H, Cao S, Han Y, et al. Synergistic effect of CH-296 and interferon gamma on cytokine-induced killer cells expansion for patients with advanced-stage malignant solid tumors. Cancer Biother. Radiopharm. 26, 485-494 (2011
    • (2011) Cancer Biother. Radiopharm , vol.26 , pp. 485-494
    • Yu, J.1    Ren, X.2    Li, H.3    Cao, S.4    Han, Y.5
  • 60
    • 84887876497 scopus 로고    scopus 로고
    • Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models
    • Tao L, Huang G, Shi S, Chen L. Bevacizumab improves the antitumor efficacy of adoptive cytokine-induced killer cells therapy in non-small cell lung cancer models. Med. Oncol. 31(1), 777 (2014
    • (2014) Med. Oncol , vol.31 , Issue.1 , pp. 777
    • Tao, L.1    Huang, G.2    Shi, S.3    Chen, L.4
  • 61
    • 79960110662 scopus 로고    scopus 로고
    • Randomized phase iii trial of paclitaxel/carboplatin with or without pf-3512676 (toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer
    • Hirsh V, Paz-Ares L, Boyer M, et al. Randomized Phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancer. J. Clin. Oncol. 29(19), 2667-2674 (2011
    • (2011) J. Clin. Oncol , vol.29 , Issue.19 , pp. 2667-2674
    • Hirsh, V.1    Paz-Ares, L.2    Boyer, M.3
  • 62
    • 0019955259 scopus 로고
    • Chemotherapy versus chemoimmunotherapy with levamisole or corynebacterium parvum in advanced lung cancer
    • Chahinian AP, Goldberg J, Holland JF, Reisman A, Jaffrey IS, Mandel EM. Chemotherapy versus chemoimmunotherapy with levamisole or Corynebacterium parvum in advanced lung cancer. Cancer Treat. Rep. 66(6), 1291-1297 (1982
    • (1982) Cancer Treat. Rep , vol.66 , Issue.6 , pp. 1291-1297
    • Chahinian, A.P.1    Goldberg, J.2    Holland, J.F.3    Reisman, A.4    Jaffrey, I.S.5    Mandel, E.M.6
  • 63
    • 0021752373 scopus 로고
    • Treatment of inoperable non-small cell carcinoma of the lung with radiation therapy, with or without levamisole a randomized trial of the southeastern cancer study group
    • Krauss S, Comas F, Perez C, et al. Treatment of inoperable non-small cell carcinoma of the lung with radiation therapy, with or without levamisole. A randomized trial of the Southeastern Cancer Study group. Am J. Clin. Oncol. 7(5), 405-412 (1984
    • (1984) Am J. Clin. Oncol , vol.7 , Issue.5 , pp. 405-412
    • Krauss, S.1    Comas, F.2    Perez, C.3
  • 64
    • 0023856762 scopus 로고
    • Post-operative thoracic irradiation with or without levamisole in non-small cell lung cancer: Results of a radiation therapy oncology group study
    • Herskovic A, Bauer M, Seydel HG, et al. Post-operative thoracic irradiation with or without levamisole in non-small cell lung cancer: Results of a Radiation Therapy Oncology Group Study. Int. J. Radiat. Oncol. Biol. Phys. 14(1), 37-42 (1988
    • (1988) Int. J. Radiat. Oncol. Biol. Phys , vol.14 , Issue.1 , pp. 37-42
    • Herskovic, A.1    Bauer, M.2    Seydel, H.G.3
  • 65
    • 0024840768 scopus 로고
    • Immunotherapy as an adjuvant to surgery in carcinoma of bronchus results in three randomised trials
    • Roeslin N, Dumont P, Morand G, Wihlm JM, Witz JP. Immunotherapy as an adjuvant to surgery in carcinoma of bronchus. Results in three randomised trials. Eur. J. Cardiothorac. Surg. 3(5), 430-435 (1989
    • (1989) Eur. J. Cardiothorac. Surg , vol.3 , Issue.5 , pp. 430-435
    • Roeslin, N.1    Dumont, P.2    Morand, G.3    Wihlm, J.M.4    Witz, J.P.5
  • 66
    • 84886944580 scopus 로고    scopus 로고
    • Sox2-specific adaptive immunity and response to immunotherapy in non-small cell lung cancer
    • Dhodapkar KM, Gettinger SN, Das R, Zebroski H, Dhodapkar MV. SOX2-specific adaptive immunity and response to immunotherapy in non-small cell lung cancer. Oncoimmunology 2(7), e25205 (2013
    • (2013) Oncoimmunology , vol.2 , Issue.7 , pp. e25205
    • Dhodapkar, K.M.1    Gettinger, S.N.2    Das, R.3    Zebroski, H.4    Dhodapkar, M.V.5
  • 67
    • 84891955964 scopus 로고    scopus 로고
    • Frequent t cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy
    • Babiak A, Steinhauser M, Götz M, Herbst C, Döhner H, Greiner J. Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy. Oncol. Rep. 31(1), 384-390 (2014
    • (2014) Oncol. Rep , vol.31 , Issue.1 , pp. 384-390
    • Babiak, A.1    Steinhauser, M.2    Götz, M.3    Herbst, C.4    Döhner, H.5    Greiner, J.6
  • 69
    • 84880855003 scopus 로고    scopus 로고
    • Immunological markers of anti-Tumor dendritic cells vaccine efficiency in patients with non-small cell lung cancer
    • Skachkova OV, Khranovska NM, Gorbach OI, Svergun NM, Sydor RI, Nikulina VV. Immunological markers of anti-Tumor dendritic cells vaccine efficiency in patients with non-small cell lung cancer. Exp. Oncol. 35(2), 109-113 (2013
    • (2013) Exp. Oncol , vol.35 , Issue.2 , pp. 109-113
    • Skachkova, O.V.1    Khranovska, N.M.2    Gorbach, O.I.3    Svergun, N.M.4    Sydor, R.I.5    Nikulina, V.V.6
  • 70
    • 80053371253 scopus 로고    scopus 로고
    • Defining the critical hurdles in cancer immunotherapy
    • Fox BA, Schendel DJ, Butterfield LH, et al. Defining the critical hurdles in cancer immunotherapy. J. Transl. Med. 9, 214 (2011
    • (2011) J. Transl. Med , vol.9 , Issue.214
    • Fox, B.A.1    Schendel, D.J.2    Butterfield, L.H.3
  • 71
    • 84880720167 scopus 로고    scopus 로고
    • Predictive gene signature in mage-A3 antigen-specific cancer immunotherapy
    • Ulloa-Montoya F, Louahed J, Dizier B, et al. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31(19), 2388-2395 (2013
    • (2013) J. Clin. Oncol , vol.31 , Issue.19 , pp. 2388-2395
    • Ulloa-Montoya, F.1    Louahed, J.2    Dizier, B.3
  • 72
    • 77953666101 scopus 로고    scopus 로고
    • The vegf family in cancer and antibody-based strategies for their inhibition
    • Sullivan LA, Brekken RA. The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs 2(2), 165-175 (2010
    • (2010) MAbs , vol.2 , Issue.2 , pp. 165-175
    • Sullivan, L.A.1    Brekken, R.A.2


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