Activation of extrasynaptic GABAA receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons

Neuroscience Bulletin

Volumn 30, Issue 5, 2014, Pages 866-876

  Wan, Li ^a   Liu, Xu ^a   Wu, Zheng ^a   Ren, Wanting ^a   Kong, Shuzhen ^a   Dargham, Raya Abou ^a   Cheng, Longzhen ^a   Wang, Yun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

cyclothiazide; epilepsy; GABAARs; hippocampal CA1 neurons; population spike; tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR SUBUNIT DELTA; CYCLOTHIAZIDE; GABOXADOL; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BENZOTHIADIAZINE DERIVATIVE; CONVULSANT AGENT; ISOXAZOLE DERIVATIVE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; EPILEPTIC DISCHARGE; EPILEPTOGENESIS; EXPERIMENTAL SEIZURE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL NEURONAL CULTURE; IN VITRO STUDY; LATENT PERIOD; MALE; NERVE CELL MEMBRANE; NERVE CELL NETWORK; NONHUMAN; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SEIZURE; SPRAGUE DAWLEY RAT;

ANIMALS; BENZOTHIADIAZINES; CA1 REGION, HIPPOCAMPAL; CONVULSANTS; DISEASE MODELS, ANIMAL; GABA AGONISTS; ISOXAZOLES; MALE; MEMBRANE POTENTIALS; NEURONS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES;

EID: 84919830721     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-014-1466-8     Document Type: Article

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