Simultaneous determination of ten alkaloids of crude and wine-processed Rhizoma Coptidis aqueous extracts in rat plasma by UHPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 105, Issue , 2015, Pages 64-73

  Qian, Xiao Cui ^a,b   Zhang, Liang ^c   Tao, Yi ^a   Huang, Ping ^a,b   Li, Jun Song ^a,b   Chai, Chuan ^a   Li, Wen ^d   Di, Liu Qing ^a,b   Cai, Bao Chang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Jiangsu Provincial TCM High Efficient Drug Delivery System (DDS) Eng Technology Research Center   (China)

^c ANHUI AGRICULTURAL UNIVERSITY   (China)

^d Nanjing Municipal Hospital of Traditional Chinese Medicine   (China)

Author keywords

Alkaloids; Pharmacokinetics; Rhizoma coptidis; Rice wine processing; UHPLC MS MS

Indexed keywords

8 OXOCOPTISINE; ACETONITRILE; ALKALOID; BERBERINE; COLUMBAMINE; COPTIS RHIZOME EXTRACT; COPTISINE; EPIBERBERINE; JATRORRHIZINE; MAGNOFLORINE; NOROXYHYDRASTININE; OXYBERBERINE; PALMATINE; UNCLASSIFIED DRUG; WATER; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; COPTIS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG STRUCTURE; ELIMINATION HALF-LIFE; ELUTION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; RAT; SAKE; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CALIBRATION; CHEMISTRY; COMPARATIVE STUDY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; RHIZOME; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STANDARD; WINE;

ALKALOIDS; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPTIS; DRUGS, CHINESE HERBAL; MALE; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; RHIZOME; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; WATER; WINE;

EID: 84919809237     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.11.049     Document Type: Article

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