Toxicological assessment of multi-walled carbon nanotubes on A549 human lung epithelial cells

Toxicology in Vitro

Volumn 29, Issue 2, 2015, Pages 352-362

  Visalli, Giuseppa ^a   Bertuccio, Maria Paola ^a   Iannazzo, Daniela ^a   Piperno, Anna ^a   Pistone, Alessandro ^a   di Pietro, Angela ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Acid treated multiwalled carbon nanotubes (MWCNT COOH); Genotoxicity; Lysosomal and mitochondrial dysfunction; Oxidative damage; Pristine multi walled carbon nanotubes (pMWCNT)

Indexed keywords

DEFEROXAMINE MESYLATE; FLUORESCEIN ISOTHIOCYANATE; HYDROPEROXIDE; IRON; KETOCONAZOLE; MULTI WALLED NANOTUBE; REACTIVE OXYGEN METABOLITE; SCAVENGER; CARBON NANOTUBE; DEFEROXAMINE; IRON CHELATING AGENT;

A549 CELL LINE; ARTICLE; CATALYST; CELL INTERACTION; CELL VIABILITY; CELLULAR PARAMETERS; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; INTERNALIZATION; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; MICRONUCLEUS; MITOCHONDRIAL COMPARTMENT; OXIDATIVE STRESS; TONOPLAST; TOXICITY ASSAY; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; LUNG; LYSOSOME; METABOLISM; MICRONUCLEUS TEST; MITOCHONDRION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; COMET ASSAY; DEFEROXAMINE; EPITHELIAL CELLS; HUMANS; IRON CHELATING AGENTS; LUNG; LYSOSOMES; MICRONUCLEUS TESTS; MITOCHONDRIA; NANOTUBES, CARBON; REACTIVE OXYGEN SPECIES;

EID: 84919807807     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.12.004     Document Type: Article

References (37)

1. Antonelli A., Serafini S., Menotta M., Sfara C., Pierigé F., Giorgi L., Ambrosi G., Rossi L., Magnani M. Improved cellular uptake of functionalized single-walled carbon nanotubes. Nanotechnology 2010, 21:425101.
2. Antunes F., Cadenas E., Brunk U.T. Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture. Biochem. J. 2001, 356:549-555.
3. Bello D., Wardle B.L., Zhang J., Yamamoto N., Santeufemio C., Hallock M., Virji M.A. Characterization of exposures to nanoscale particles and fibers during solid core drilling of hybrid carbon nanotube advanced composites. Int. J. Occup. Environ. Health 2010, 16:434-450.
4. Bottini M., Bruckner S., Nika K., Bottini N., Bellucci S., Magrini A., Bergamaschi A., Mustelin T. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol. Lett. 2006, 160:121-126.
5. Castranova V., Schulte P.A., Zumwalde R.D. Occupational nanosafety considerations for carbon nanotubes and carbon nanofibers. Acc. Chem. Res. 2013, 46:642-649.
6. Cavallo D., Canizza C., Ursini C.L., Casciardi S., Paba E., Cervo A., Fresegna A.M., Macello R., Marcelloni A.M., Buresti G., Tombolino F., Bellocci S., Iavicoli S. Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells. J. Appl. Toxicol. 2012, 32:454-464.
7. Collins A.R., Oscoz A.A., Brunborg G., Gaivão I., Giovannelli L., Kruszewski M., Smith C.C., Stetina R. The comet assay: topical issues. Mutagenesis 2008, 23:143-151.
8. Di Pietro A., Visalli G., Munaò F., Baluce B., La Maestra S., Primerano P., Corigliano F., De Flora S. Oxidative damage in human epithelial alveolar cells exposed in vitro to oil fly ash transition metals. Int. J. Hyg. Environ. Health 2009, 212:196-208.
9. Di Pietro A., Visalli G., Baluce B., Micale R.T., La Maestra S., Spataro P., De Flora S. Multigenerational mitochondrial alterations in pneumocytes exposed to oil fly ash metals. Int. J. Hyg. Environ. Health 2011, 214:138-144.
10. Donaldson K., Poland C.A., Murphy F.A., MacFarlane M., Chernova T., Schinwald A. Pulmonary toxicity of carbon nanotubes and asbestos - similarities and differences. Adv. Drug Deliv. Rev. 2013, 65:2078-2086.
11. Donato M.G., Galvagno S., Messina G., Milone C., Pistone A., Santangelo S. Optimisation of gas mixture composition for the preparation of high quality MWCNT by catalytically assisted CVD. Diam. Relat. Mater. 2007, 16:1095-1100.
12. Firme C.P., Bandaru P.R. Toxicity issues in the application of carbon nanotubes to biological systems. Nanomedicine 2010, 6:245-256.
13. Garza K.M., Soto K.F., Murr L.E. Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials. Int. J. Nanomed. 2008, 3:83-94.
14. Guo F., Ma N., Horibe Y., Kawanishi S., Murata M., Hiraku Y. Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells. Toxicol. Appl. Pharmacol. 2012, 260:183-192.
15. Iannazzo D., Piperno A., Ferlazzo A., Pistone A., Milone C., Lanza M., Cimino F., Speciale A., Trombetta D., Saija A., Galvagno S. Functionalization of multi-walled carbon nanotubes with coumarin derivatives and their biological evaluation. Org. Biomol. Chem. 2012, 10:1025-1031.
16. Jacobsen N.R., Moller P., Jensen K.A., Vogel U., Ladefoged O., Loft S., Wallin H. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice. Part Fibre Toxicol. 2009, 6:2.
17. Kamp D.W., Panduri V., Weitzman S.A., Chandel N. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Mol. Cell Biochem. 2002, 234-235:153-160.
18. Kato T., Totsuka Y., Ishino K., Matsumoto Y., Tada Y., Nakae D., Goto S., Masuda S., Ogo S., Kawanishi M., Yagi T., Matsuda T., Watanabe M., Wakabayashi K. Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems. Nanotoxicology 2013, 7:452-461.
19. Kayat J., Gajbhiye V., Tekade R.K., Jain N.K. Pulmonary toxicity of carbon nanotubes: a systematic report. Nanomedicine 2011, 7:40-49.
20. Magrez A., Kasas S., Salicio V., Pasquier N., Seo J.W., Celio M., Catsicas S., Schwaller B., Forró L. Cellular toxicity of carbon-based nanomaterials. Nano Lett. 2006, 6:1121-1125.
21. Migliore L., Saracino D., Bonelli A., Colognato R., D'Errico M.R., Magrini A., Bergamaschi A., Bergamaschi E. Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells. Environ. Mol. Mutagen. 2010, 51:294-303.
22. Muller J., Huaux F., Moreau N., Misson P., Heilier J.F., Delos M., Arras M., Fonseca A., Nagy J.B., Lison D. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol. Appl. Pharmacol. 2005, 207:221-231.
23. Muller J., Huaux F., Fonseca A., Nagy J.B., Moreau N., Delos M., Raymundo-Piñero E., Béguin F., Kirsch-Volders M., Fenoglio I., Fubini B., Lison D. Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects. Chem. Res. Toxicol. 2008, 21:1698-1705.
24. Pistone A., Ferlazzo A., Lanza M., Milone C., Iannazzo D., Piperno A., Piperopoulos E., Galvagno S. Morphological modification of MWCNT functionalized with HNO3/H2SO4 mixtures. J. Nanosci. Nanotechnol. 2012, 12:5054-5060.
25. Poland C.A. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat. Nanotechnol. 2008, 3:423-428.
26. Pulskamp K., Diabate S., Krug H.F. Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants. Toxicol. Lett. 2007, 168:58-74.
27. Riviere N.A., Nemanich R.J., Inman A.O., Wang Y.Y., Riviere J.E. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol. Lett. 2005, 155:377-384.
28. Rosefort C., Fauth E., Zankl H. Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay. Mutagenesis 2004, 19:277-284.
29. Shvedova A.A., Castranova V., Kisin K.R., Schwegler-Berry D., Murray A.R., Gandelsman V.Z. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 2003, 66:1909-1926.
30. Sohaebuddin S.K., Thevenot P.T., Baker D., Eaton J.W., Tang L. Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol. 2010, 7:22.
31. Tice R.R., Agurell E., Andersen D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
32. Trifunovic A., Larsson N.G. Mitochondrial dysfunction as a cause of ageing. J. Intern. Med. 2008, 263:167-178.
33. Upadhyay D., Panduri V., Ghio A., Kamp D.W. Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am. J. Respir. Cell Mol. Biol. 2003, 29:180-187.
34. Ursini C.L., Cavallo D., Fresegna A.M., Ciervo A., Maiello R., Buresti G., Casciardi S., Tombolini F., Bellucci S., Iavicoli S. Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells. Toxicol. In Vitro 2012, 26:831-840.
35. Wei Y.H., Wu S.B., Ma Y.S., Lee H.C. Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging. Chang Gung Med. J. 2009, 32:113-132.
36. Wu M., Neilson A., Swift A.L., Moran R., Tamagnine J., Parslow D., Armistead S., Lemire K., Orrell J., Teich J., Chomicz S., Ferrick D.A. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am. J. Physiol. Cell Physiol. 2007, 292:C125-C136.
37. Zhang Q., Huang J.Q., Qian W.Z., Zhang Y.Y., Wei F. The road for nanomaterials industry: a review of carbon nanotubeproduction, post-treatment, and bulk applications for composites and energy storage. Small 2013, 9(8):1237-1265.