The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 35770-35780

  Camus, Gregory ^a   Schweiger, Martina ^a,b   Herker, Eva ^a,c,d   Harris, Charles ^c,e,f,g   Kondratowicz, Andrew S ^a   Tsou, Chia Lin ^a   Farese, Robert V ^a,c,e,f   Herath, Kithsiri ^h   Previs, Stephen F ^f   Roddy, Thomas P ^h   Pinto, Shirly ^h   Zechner, Rudolf ^b   Ott, Melanie ^a,c,f  

^a GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^e GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DROPS; ENZYMES; HEALTH RISKS; MAMMALS; PHOSPHOLIPIDS; VIRUSES;

CELLULAR ORGANELLES; CO-IMMUNOPRECIPITATION EXPERIMENTS; GENE IDENTIFICATION; HEPATITIS C VIRUS; LIPID DROPLETS; LIPOLYTIC ENZYMES; LIVER STEATOSIS; MOUSE EMBRYONIC FIBROBLASTS;

PROTEINS;

ADIPOSE TRIACYLGLYCEROL LIPASE; COMPARATIVE GENE IDENTIFICATION 58; CORE PROTEIN; ENZYME ACTIVATOR; FAT DROPLET; HEPATITIS C CORE ANTIGEN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; 1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ABHD5 PROTEIN, MOUSE; DESNUTRIN PROTEIN, MOUSE; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CELL ORGANELLE; CONTROLLED STUDY; EMBRYO; FATTY LIVER; HEPATITIS C; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOPRECIPITATION; ISOTOPE LABELING; LIPID DEGRADATION; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ULTRACENTRIFUGATION; VIRION; 3T3 CELL LINE; ANIMAL; C57BL MOUSE; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; ENZYMOLOGY; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

HEPATITIS C VIRUS; MUS;

1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; ANIMALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HUMANS; HYDROLYSIS; LIPASE; LIPID DROPLETS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NIH 3T3 CELLS; TRIGLYCERIDES; VIRAL CORE PROTEINS;

EID: 84919793281     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.587816     Document Type: Article

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