Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Polavarapu, Sailaja ^a   Mani, Arul M ^a   Gundala, Naveen K V ^a   Hari, Anasuya D ^a   Bathina, Siresha ^a   Das, Undurti N ^b   Nie, Daotai ^c  

^a GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING   (India)

^b UND Life Sciences   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10,17 DIHYDROXY 4,7,11,13,15,19 DOCOSAHEXAENOIC ACID; 19,20 DIHYDROXYDOCOSAPENTAENOATE; ARACHIDONIC ACID; BLEOMYCIN; CD59 ANTIGEN; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; DRUG METABOLITE; GAMMA LINOLENIC ACID; GLUTATHIONE PEROXIDASE; ICOSAPENTAENOIC ACID; INDOMETACIN; LEUKOTRIENE D4; LEUKOTRIENE E4; LINOLEIC ACID; LIPID PEROXIDE; LIPOXIN A; NITRIC OXIDE; NORDIHYDROGUAIARETIC ACID; POLYUNSATURATED FATTY ACID; PROSTACYCLIN; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; RESOLVIN D1; RESOLVIN D2; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ANTIOXIDANT; CELL EXTRACT; LEUKOTRIENE; LIPOXIN; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; UNSATURATED FATTY ACID;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMR 32 CELL LINE; IN VITRO STUDY; NEUROBLASTOMA CELL LINE; OXIDATIVE STRESS; TUMOR GROWTH; CELL DEATH; DRUG EFFECTS; LIPID PEROXIDATION; METABOLISM; NEUROBLASTOMA; PATHOLOGY; TIME; TUMOR CELL LINE;

ANTIGENS, CD59; ANTIOXIDANTS; ARACHIDONIC ACID; BLEOMYCIN; CELL DEATH; CELL EXTRACTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE INHIBITORS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, UNSATURATED; HUMANS; LEUKOTRIENES; LIPID PEROXIDATION; LIPOXINS; LIPOXYGENASE INHIBITORS; NEUROBLASTOMA; NITRIC OXIDE; PROSTAGLANDINS; TIME FACTORS;

EID: 84919785677     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114766     Document Type: Article

References (75)

1. Begin ME, Ells G, Das UN, Horrobin DF (1986) Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. J Natl Cancer Inst 77: 1053-1062.
2. Das UN (1991) Tumoricidal action of cis-unsaturated fatty acids and its relationship to free radicals and lipid peroxidation. Cancer Lett 56: 235-243.
3. Ge H, Kong X, Shi L, Hou L, Liu Z, Li P (2009) Gamma-linolenic acid induces apoptosis and lipid peroxidation in human chronic myelogenous leukemia K562cells. Cell Biol Int 33: 402-410.
4. Begin ME, Das UN, Ells G (1986) Cytotoxic effects of essential fatty acids (EFA) in mixed cultures of normal and malignant human cells. Prog Lipid Res 25: 573-576.
5. Das UN (2004) From bench to the clinic: c-linolenic acid therapy of human gliomas. Prostaglandins Leukot Essent Fatty Acids 70: 539-552.
6. Gillis RC, Daley BJ, Enderson BL, Karlstad MD (2002) Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells. J Surg Res 107: 145-153.
7. Madhavi N, Das UN (1994) Effect of n-6 and n-3 fatty acids on the survival of vincristine sensitive and resistant human cervical carcinoma cells in vitro. Cancer Lett 84: 31-41.
8. Kumar GS, Das UN (1995) Free Radical dependent suppression of mouse myeloma cells by alphalinolenic and eicosapentaenoic acids in vitro. Cancer Lett 92: 27-38.
9. Pompeia C, Freitas JJS, Kim JS, Zyngier SB, Curi R (2002) Arachidonic acid cytotoxicity in leukocytes: implications of oxidative stress and eicosanoid synthesis. Biol Cell 94: 251-265.
10. Rizoo MT, Regazzi E, Garau D, Akard L, Dugan M, et al. (1999) Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. Cancer Res 59: 5047-5053.
11. Ramesh G, Das UN (1998) Effect of cis-unsaturated fatty acids on Meth-A ascitic tumor cells in vitro and in vivo. Cancer Letters 123: 207-214.
12. Lu X, Yu H, Shen S, Das UN (2010) Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. Lipids Health Dis 9: 106.
13. Vang K, Ziboh VA (2005) 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. Prostaglandins Leukot Essent Fatty Acids 72: 363-372.
14. Vartak S, McCaw R, Davis CS, Robbins MEC, Spector AA (1998) Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. Br J Cancer 77: 1612-1620.
15. Ramesh G, Das UN, Koratkar R, Padma M, Sagar PS (1992) Effect of essential fatty acids on tumor cells. Nutrition 8: 343-347.
16. Krenzel ES, Chen Z, Hamilton JA (2013) Correspondence of fatty acid and drug binding sites on human serum albumin: a two-dimensional nuclear magnetic resonance study. Biochemistry 52: 1559- 1567.
17. Brock TG (2008) Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Lipids 43: 161-169.
18. Sangeetha PS, Das UN (1993) Gamma-linolenic acid and eicosapentaenoic acid potentiate the cytotoxicity of anti-cancer drugs on human cervical carcinoma (HeLa) cells in vitro. Med Sci Res 21: 457-459.
19. De Carlo F, Witte TR, Hardman WE, Claudio PP (2013) Omega-3 eicosapentaenoic acid decreases CD133 colon cancer stem-like cell marker expression while increasing sensitivity to chemotherapy. PLoS One 8: e69760.
20. Fahrmann JF, Hardman WE (2013) Omega 3 fatty acids increase the chemo-sensitivity of B-CLL derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. Lipids Health Dis 12: 36.
21. Mahéo K, Vibet S, Steghens JP, Dartigeas C, Lehman M, et al. (2005) Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. Free Radic Biol Med 39: 742-751.
22. Germain E, Chajès V, Cognault S, Lhuillery C, Bougnoux P (1998) Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. Int J Cancer 75: 578-583.
23. Wirtitsch M, Roth E, Bachleitner-Hofmann T, Wessner B, Sturlan S (2009) Omega-3 and omega-6 polyunsaturated fatty acids enhance arsenic trioxide efficacy in arsenic trioxide-resistant leukemic and solid tumor cells. Oncol Res 18: 83-94.
24. Mengeaud V, Nano JL, Fournel S, Rampal P (1992) Effects of eicosapentaenoic acid, gamma-linolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. Prostaglandins Leukot Essent Fatty Acids 47: 313-319.
25. Botha JH, Robinson KM, Leary WP (1985) The response of human carcinoma cell lines to gammalinolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis. Prostaglandins Leukot Med 19: 63-77.
26. Botha JH, Robinson KM, Ramchurren N, Norman RJ (1989) The role of prostaglandins in the inhibition of cultured carcinoma cell growth produced by gamma-linolenic acid. Prostaglandins Leukot Essent Fatty Acids 35: 119-123.
27. Avis I, Martínez A, Tauler J, Zudaire E, Mayburd A, et al. (2005) Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. Cancer Res 65: 4181-4190.
28. Scioscia KA, Snyderman CH, D'Amico F, Comsa S, Rueger R, et al. (2000) Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma. Head Neck 22: 149-155.
29. Santoro MG, Crisari A, Benedetto A, Amici C (1986) Modulation of the growth of a human erythroleukemic cell line (K562) by prostaglandins: anti proliferative action of prostaglandin A. Cancer Res 46 (12 Pt 1): 6073-6077.
30. de Bittencourt PI Jr, Miyasaka CK, Curi R, Williams JF (1998) Effects of the anti proliferative cyclopentenone prostaglandin A1 on glutathione metabolism in human cancer cells in culture. Bio chem Mol Biol Int 45: 1255-1264.
31. Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN (1998) Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 58: 362-366.
32. Zweifel BS, Davis TW, Ornberg RL, Masferrer JL (2002) Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors. Cancer Res 62: 6706-6711.
33. Sheng H, Shao J, Washington MK, DuBois RN (2001) Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 276: 18075-18081.
34. Yu L, Wu WK, Li ZJ, Li HT, Wu YC, et al. (2009) Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. Int J Cancer 125: 2540-2546.
35. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS (2005) Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310: 1504-1510.
36. Dajani OF, Meisdalen K, Guren TK, Aasrum M, Tveteraas IH, et al. (2008) Prostaglandin E2 up regulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes. J Cell Physiol 214: 371-380.
37. Li C, Lee PS, Sun Y, Gu X, Zhang E, et al. (2014) Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med 211: 15-28.
38. Ayyub Khan M, Tateson JE, Hoffbrand AV, Wickremasinghe RG (1993) Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant haemopoietic cell lines. Leuk Res 17: 241-245.
39. Snyder DS, Castro R, Desforges JF (1989) Anti proliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines. Exp Hematol 17: 6-9.
40. Kobayashi H, Ojima M, Satoh H (1985) Effects of 6-keto-prostaglandin E1 on ascitic hepatoma-130 in vivo comparison with chemotherapeutic agents. Prostaglandins 29: 255-268.
41. Morita I (1983) Regulation of cell growth by prostaglandins. Gan To Kagaku Ryoho 10: 1919-1929.
42. Smith DL, Willis AL, Mahmud I (1984) Eicosanoid effects on cell proliferation in vitro: relevance to atherosclerosis. Prostaglandins Leukot Med 16: 1-10.
43. Clà ria J, Lee MH, Serhan CN (1996) Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol Med 2: 583-596.
44. Beckman BS, Despinasse BP, Spriggs L (1992) Actions of lipoxins A4 and B4 on signal transduction events in Friend erythroleukemia cells. Proc Soc Exp Biol Med 201: 169-173.
45. Das UN (2012) Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4. Prostaglandins Leukot Essent Fatty Acids 86: 3-11.
46. Hao H, Liu M, Wu P, Cai L, Tang K, et al. (2011) Lipoxin A4 and its analog suppress hepato cellular carcinoma via remodeling tumor microenvironment. Cancer Lett 309: 85-94.
47. Chen Y, Hao H, He S, Cai L, Li Y, et al. (2010) Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: The role of anti angiogenesis. Mol Cancer Ther 9: 2164-2174.
48. Sailaja Devi MM, Suresh Y, Das UN (2000) Preservation of antioxidant status in chemically-induced diabetes mellitus by melatonin. J Pineal Res 29: 108-115.
49. Suresh Y, Sailaja Devi MM, Manjari V, Das UN (2000) Oxidant stress, antioxidants and nitric oxide in traffic police of Hyderabad, India. Environmental Pollution 109: 321-325.
50. Suresh Y, Das UN (2001) Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins Leukot Essen Fatty Acids 64: 37-52.
51. Suresh Y, Das UN (2001) Oxidant stress, anti-oxidants and essential fatty acids in South Indian vegetarians and non-vegetarians. Prostaglandins Leukot Essen Fatty Acids 64: 53-59.
52. Suresh Y, Das UN (2003) Long-chain polyunsaturated fatty acids and chemically-induced diabetes mellitus: Effect of v-6 fatty acids. Nutrition 19: 93-114.
53. Suresh Y, Das UN (2003) Long-chain polyunsaturated fatty acids and chemically-induced diabetes mellitus: Effect of v-3 fatty acids. Nutrition 19: 213-228.
54. Madhavi N, Das UN (1994) Effect of n-6 and n-3 fatty acids on the survival of vincristine sensitive and resistant human cervical carcinoma cells in vitro. Cancer Lett 84: 31-41.
55. Kumar SG, Das UN (1995) Free Radical dependent suppression of mouse myeloma cells by alphalinolenic and eicosapentaenoic acids in vitro. Cancer Lett 92: 27-38.
56. Giri SN, Chen ZL, Younker WR, Schiedt MJ (1983) Effects of intra tracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters. Toxicol Appl Pharmacol 71: 132-141.
57. Russo A, Mitchell JB, McPherson S, Friedman N (1984) Alteration of bleomycin cytotoxicity by glutathione depletion or elevation. Int J Radiat Oncol Biol Phys 10: 1675-1678.
58. Zeidler RB, Yarbro JW, Conley NS (1987) Bleomycin increases superoxide production in the most active alveolar macrophage subpopulation. Int J Immunopharmacol 9: 691-696.
59. Mun GI, An SM, Park H, Jo H, Boo YC (2008) Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells. Am J Physiol Heart Circ Physiol 295: H1966- H1973.
60. Das UN (2008) Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, antiinflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis 7: 37.
61. Das UN (2006) Essential fatty acids-a review. Current Pharmaceut Biotech 7: 467-482.
62. Das UN (2006) Essential fatty acids: Biochemistry, physiology, and pathology. Bio technology J 1: 420- 439.
63. Rose DP, Connolly JM, Liu XH (1994) Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro. Cancer Res 54: 6557-6562.
64. Rose DP, Hatala MA, Connolly JM, Rayburn J (1993) Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice. 53: 4686-4690.
65. Rose DP, Connolly JM, Liu XH (1995) Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. Nutr Cancer 24: 33-45.
66. Mouradian M, Kikawa KD, Johnson ED, Beck KL, Pardini RS (2014) Key roles for GRB2-associatedbinding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced up regulation of lung and breast cancer cell growth. Prostaglandins Leukot Essent Fatty Acids 90: 105-115.
67. Robinson KM, Botha JH (1985) Effects of gamma-linolenic acid, dihomo-gamma-linolenic acid and ethanol on cultured human mammary carcinoma cells. Prostaglandins Leukot Med 20: 209-221.
68. Jiang WG, Bryce RP, Horrobin DF, Mansel RE (1998) gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. Int J Oncol 13: 611-617.
69. Kenny FS, Gee JM, Nicholson RI, Ellis IO, Morris TM, et al. (2001) Effect of dietary GLA+/2tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xeno grafts. Int J Cancer 92: 342-347.
70. Menendez JA, Vellon L, Colomer R, Lupu R (2005) Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. J Natl Cancer Inst 97: 1611-1615.
71. Kirkova M, Kassabova T, Russanov E (1992) In vivo effects of indomethacin-I. Activity of antioxidant enzymes and lipid peroxidation. General Pharmacology: The Vascular System 23: 503-507.
72. Lü J-M, Nurko J, Weakley SM, Jiang J, Kougias P, et al. (2010) Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: An update. Med Sci Monit 16: RA93-R100.
73. Deby-Dupont G, Ducarne H, de Landsheere C, Ancion JC, Noël FX, et al. (1983) Intense rises of unesterified arachidonate plasma levels in stressed humans. Biomed Pharmacother 37: 386-391.
74. Phillips DG, Dodge JT (1967) Composition of phospholipids and of phospholipid fatty acids of human plasma. J Lipid Res 8: 676-681.
75. Bhat KS, Bhavani B (1967) Biochemical studies in phrynoderma (follicular hyperkeratosis). II. Polyunsaturated fatty acid levels in plasma and erythrocytes of patients suffering from phrynoderma. Am J Clin Nutr 20: 386-392.