GATA-1 deficiency rescues trabecular but not cortical bone in OPG deficient mice

Journal of Cellular Physiology

Volumn 230, Issue 4, 2015, Pages 783-790

  Meijome, Tomas E ^a   Hooker, R Adam ^a   Cheng, Ying Hua ^a   Walker, Whitney ^a   Horowitz, Mark C ^b   Fuchs, Robyn K ^c   Kacena, Melissa A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOPROTEGERIN; TRANSCRIPTION FACTOR GATA 1; GATA1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOMECHANICS; BONE STRENGTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; GENE SILENCING; MEGAKARYOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOPOROSIS; PHENOTYPE; POROSITY; PRIORITY JOURNAL; RIGIDITY; TRABECULAR BONE; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; DEFICIENCY; GENETICS; METABOLISM; OSTEOBLAST; OSTEOLYSIS; TRANSGENIC MOUSE;

MUS;

ANIMALS; BONE RESORPTION; FEMUR; GATA1 TRANSCRIPTION FACTOR; MEGAKARYOCYTES; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPROTEGERIN;

EID: 84919740811     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24803     Document Type: Article

References (29)

1. Beeton CA, Bord S, Ireland D, Compston JE. 2006. Osteoclast formation and bone resorption are inhibited by megakaryocytes. Bone 39:985-990.
2. Bord S, Frith E, Ireland DC, Scott MA, Craig JI, Compston JE. 2005. Megakaryocytes modulate osteoblast synthesis of type-l collagen, osteoprotegerin, and RANKL. Bone 36:812-819.
3. Breton-Gorius J, Clezardin P, Guichard J, Debili N, Malaval L, Vainchenker W, Cramer EM, Delmas PD. 1992. Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes. Blood 79:936-941.
4. Drachman JG, Sabath DF, Fox NE, Kaushansky K. 1997. Thrombopoietin signal transduction in purified murine megakaryocytes. Blood 89:483-492.
5. Feher A, Koivunemi A, Koivunemi M, Fuchs RK, Burr DB, Phipps RJ, Reinwald S, Allen MR. 2010. Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading. Bone 46:203-207.
6. Horowitz MC, Fields A, DeMeo D, Qian HY, Bothwell AL, Trepman E. 1994. Expression and regulation of Ly-6 differentiation antigens by murine osteoblasts. Endocrinology 135:1032-1043.
7. Jilka RL, Cohn DV. 1981. Role of phosphodiesterase in the parathormone-stimulated adenosine 3′, 5′-monophosphate response in bone cell populations enriched in osteoclasts and osteoblasts. Endocrinology 109:743-747.
8. Kacena MA, Gundberg CM, Nelson T, Horowitz MC. 2005. Loss of the transcription factor p45 NF-E2 results in a developmental arrest of megakaryocyte differentiation and the onset of a high bone mass phenotype. Bone 36:215-223.
9. Kacena MA, Gundberg CM, Kacena WJ, III, Landis WJ, Boskey AL, Bouxsein ML, Horowitz MC. 2013. The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties. J Cell Physiol 228:1594-1600.
10. Kacena MA, Nelson T, Clough ME, Lee SK, Lorenzo JA, Gundberg CM, Horowitz MC. 2006. Megakaryocyte-mediated inhibition of osteoclast development. Bone 39:991-999.
11. Kacena MA, Shivdasani RA, Wilson K, Xi Y, Troiano N, Nazarian A, Gundberg CM, Bouxsein ML, Lorenzo JA, Horowitz MC. 2004. Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res 19:652-660.
12. Kelm RJ, Jr., Hair GA, Mann KG, Grant BW. 1992. Characterization of human osteoblast and megakaryocyte-derived osteonectin (SPARC). Blood 80:3112-3119.
13. McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. 1997. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci USA 94:6781-6785.
14. Miao D, Murant S, Scutt N, Genever P, Scutt A. 2004. Megakaryocyte-bone marrow stromal cell aggregates demonstrate increased colony formation and alkaline phosphatase expression in vitro. Tissue Eng 10:807-817.
15. Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ. 1997a. Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood 90:1821-1827.
16. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. 1997b. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 16:3965-3973.
17. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. 1995. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695-704.
18. Simmons DJ, Kent GN, Jilka RL, Scott DM, Fallon M, Cohn DV. 1982. Formation of bone by isolated, cultured osteoblasts in millipore diffusion chambers. Calcif Tissue Int 34:291-294.
19. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G Tarpley, Derby P, Lee R, Boyle WJ. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
20. Sipe JB, Zhang J, Waits C, Skikne B, Garimella R, Anderson HC. 2004. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Bone 35:1316-1322.
21. Suva LJ, Hartman E, Dilley JD, Russell S, Akel NS, Skinner RA, Hogue WR, Budde U, Varughese KI, Kanaji T, Ware J. 2008. Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathol 172:430-439.
22. Thiede MA, Smock SL, Petersen DN, Grasser WA, Thompson DD, Nishimoto SK. 1994. Presence of messenger ribonucleic acid encoding osteocalcin, a marker of bone turnover, in bone marrow megakaryocytes and peripheral blood platelets. Endocrinology 135:929-937.
23. Vannucchi AM, Bianchi L, Cellai C, Paoletti F, Rana RA, Lorenzini R, Migliaccio G, Migliaccio AR. 2002. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice). Blood 100:1123-1132.
24. Villeval JL, Cohen-Solal K, Tulliez M, Giraudier S, Guichard J, Burstein SA, Cramer EM, Vainchenker W, Wendling F. 1997. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 90:4369-4383.
25. Warden SJ, Nelson IR, Fuchs RK, Bliziotes MM, Turner CH. 2008. Serotonin (5-hydroxytryptamine) transporter inhibition causes bone loss in adult mice independently of estrogen deficiency. Menopause 15:1176-1183.
26. Weatherholt AM, Fuchs RK, Warden SJ. 2013. Cortical and trabecular bone adaptation to incremental load magnitudes using the mouse tibial axial compression loading model. Bone 52:372-379.
27. Wickenhauser C, Lorenzen J, Thiele J, Hillienhof A, Jungheim K, Schmitz B, Hansmann ML, Fischer R. 1995. Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood 85:685-691.
28. Wong GL, Cohn DV. 1975. Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces. Proc Natl Acad Sci USA 72:3167-3171.
29. Yan XQ, Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG, McNiece IK. 1996. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation. Blood 88:402-409.