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Volumn 46, Issue 1, 2010, Pages 203-207

Bisphosphonates do not inhibit periosteal bone formation in estrogen deficient animals and allow enhanced bone modeling in response to mechanical loading

Author keywords

Alendronate; Ovariectomy; Risedronate; Ulna loading; Zoledronate

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; ESTROGEN; RISEDRONIC ACID; ZOLEDRONIC ACID;

EID: 72049103657     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.023     Document Type: Article
Times cited : (47)

References (49)
  • 3
    • 0037172407 scopus 로고    scopus 로고
    • Pathogenesis of bone fragility in women and men
    • Seeman E. Pathogenesis of bone fragility in women and men. Lancet 359 (2002) 1841-1850
    • (2002) Lancet , vol.359 , pp. 1841-1850
    • Seeman, E.1
  • 5
    • 0024404114 scopus 로고
    • Differential effects of gonadal function on bone histomorphometry in male and female rats
    • Turner R.T., Hannon K.S., Demers L.M., Buchanan J., and Bell N.H. Differential effects of gonadal function on bone histomorphometry in male and female rats. J. Bone Miner. Res. 4 (1989) 557-563
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 557-563
    • Turner, R.T.1    Hannon, K.S.2    Demers, L.M.3    Buchanan, J.4    Bell, N.H.5
  • 6
    • 0031028594 scopus 로고    scopus 로고
    • Short-term effects of high dose estrogen on tibiae of growing male rats
    • Wakley G.K., Evans G.L., and Turner R.T. Short-term effects of high dose estrogen on tibiae of growing male rats. Calcif. Tissue Int. 60 (1997) 37-42
    • (1997) Calcif. Tissue Int. , vol.60 , pp. 37-42
    • Wakley, G.K.1    Evans, G.L.2    Turner, R.T.3
  • 7
    • 0036726252 scopus 로고    scopus 로고
    • Effects of raloxifene on bone density, biomarkers, and histomorphometric and biomechanical measures in ovariectomized cynomolgus monkeys
    • Lees C.J., Register T.C., Turner C.H., Wang T., Stancill M., and Jerome C.P. Effects of raloxifene on bone density, biomarkers, and histomorphometric and biomechanical measures in ovariectomized cynomolgus monkeys. Menopause 9 (2002) 320-328
    • (2002) Menopause , vol.9 , pp. 320-328
    • Lees, C.J.1    Register, T.C.2    Turner, C.H.3    Wang, T.4    Stancill, M.5    Jerome, C.P.6
  • 9
    • 0142122926 scopus 로고    scopus 로고
    • Toward an expanded understanding of the role of the periosteum in skeletal health
    • Orwoll E. Toward an expanded understanding of the role of the periosteum in skeletal health. J. Bone Miner. Res. 18 (2003) 949-954
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 949-954
    • Orwoll, E.1
  • 10
    • 0026514225 scopus 로고
    • Sex differences in geometry of the femoral neck with aging: a structural analysis of bone mineral data
    • Beck T.J., Ruff C.B., Scott Jr. W.W., Plato C.C., Tobin J.D., and Quan C.A. Sex differences in geometry of the femoral neck with aging: a structural analysis of bone mineral data. Calcif. Tissue Int. 50 (1992) 24-29
    • (1992) Calcif. Tissue Int. , vol.50 , pp. 24-29
    • Beck, T.J.1    Ruff, C.B.2    Scott Jr., W.W.3    Plato, C.C.4    Tobin, J.D.5    Quan, C.A.6
  • 11
    • 0036137393 scopus 로고    scopus 로고
    • Different effects of antiresorptive therapies on vertebral and nonvertebral fractures in postmenopausal osteoporosis
    • Delmas P.D. Different effects of antiresorptive therapies on vertebral and nonvertebral fractures in postmenopausal osteoporosis. Bone 30 (2002) 14-17
    • (2002) Bone , vol.30 , pp. 14-17
    • Delmas, P.D.1
  • 12
    • 0036185685 scopus 로고    scopus 로고
    • Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint
    • Marcus R., Wong M., Heath III H., and Stock J.L. Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint. Endocr. Rev. 23 (2002) 16-37
    • (2002) Endocr. Rev. , vol.23 , pp. 16-37
    • Marcus, R.1    Wong, M.2    Heath III, H.3    Stock, J.L.4
  • 13
    • 0034080243 scopus 로고    scopus 로고
    • How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis?
    • Delmas P.D. How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis?. Bone 27 (2000) 1-3
    • (2000) Bone , vol.27 , pp. 1-3
    • Delmas, P.D.1
  • 14
    • 43049109229 scopus 로고    scopus 로고
    • Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
    • Russell R.G., Watts N.B., Ebetino F.H., and Rogers M.J. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos. Int. 19 (2008) 733-759
    • (2008) Osteoporos. Int. , vol.19 , pp. 733-759
    • Russell, R.G.1    Watts, N.B.2    Ebetino, F.H.3    Rogers, M.J.4
  • 15
    • 0028001748 scopus 로고
    • Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage
    • Bikle D., Morey-Holton E., Doty S., Currier P., Tanner S., and Halloran B. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J. Bone Miner. Res. 9 (1994) 1777-1787
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 1777-1787
    • Bikle, D.1    Morey-Holton, E.2    Doty, S.3    Currier, P.4    Tanner, S.5    Halloran, B.6
  • 16
    • 33749518855 scopus 로고    scopus 로고
    • Bisphosphonates suppress periosteal osteoblast activity independent of resorption in rat femur and tibia
    • Iwata K., Li J., Follet H., Phipps R.J., and Burr D.B. Bisphosphonates suppress periosteal osteoblast activity independent of resorption in rat femur and tibia. Bone 39 (2006) 1053-1058
    • (2006) Bone , vol.39 , pp. 1053-1058
    • Iwata, K.1    Li, J.2    Follet, H.3    Phipps, R.J.4    Burr, D.B.5
  • 17
    • 0344825808 scopus 로고    scopus 로고
    • Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption
    • Nakamura M., Udagawa N., Matsuura S., Mogi M., Nakamura H., Horiuchi H., et al. Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology 144 (2003) 5441-5449
    • (2003) Endocrinology , vol.144 , pp. 5441-5449
    • Nakamura, M.1    Udagawa, N.2    Matsuura, S.3    Mogi, M.4    Nakamura, H.5    Horiuchi, H.6
  • 18
    • 52949127298 scopus 로고    scopus 로고
    • Recovery of trabecular and cortical bone turnover following discontinuation of risedronate and alendronate therapy in ovariectomized rats
    • Fuchs R.K., Phipps R.J., and Burr D.B. Recovery of trabecular and cortical bone turnover following discontinuation of risedronate and alendronate therapy in ovariectomized rats. J. Bone Miner. Res. 23 (2008) 1689-1697
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 1689-1697
    • Fuchs, R.K.1    Phipps, R.J.2    Burr, D.B.3
  • 19
    • 0035992661 scopus 로고    scopus 로고
    • Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    • Robling A.G., Hinant F.M., Burr D.B., and Turner C.H. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J. Bone Miner. Res. 17 (2002) 1545-1554
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 1545-1554
    • Robling, A.G.1    Hinant, F.M.2    Burr, D.B.3    Turner, C.H.4
  • 20
    • 0035192335 scopus 로고    scopus 로고
    • Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location
    • Hsieh Y.F., Robling A.G., Ambrosius W.T., Burr D.B., and Turner C.H. Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location. J. Bone Miner. Res. 16 (2001) 2291-2297
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 2291-2297
    • Hsieh, Y.F.1    Robling, A.G.2    Ambrosius, W.T.3    Burr, D.B.4    Turner, C.H.5
  • 21
    • 0025013946 scopus 로고
    • Frequency distributions of tetracycline-based measurements: implications for the interpretation of bone formation indices in the absence of double-labeled surfaces
    • Foldes J., Shih M.S., and Parfitt A.M. Frequency distributions of tetracycline-based measurements: implications for the interpretation of bone formation indices in the absence of double-labeled surfaces. J. Bone Miner. Res. 5 (1990) 1063-1067
    • (1990) J. Bone Miner. Res. , vol.5 , pp. 1063-1067
    • Foldes, J.1    Shih, M.S.2    Parfitt, A.M.3
  • 22
    • 37549071454 scopus 로고    scopus 로고
    • Positive effects of intravenous zoledronic acid on bone remodeling and structure: are different effects on osteoblast activity to other oral bisphosphonates responsible?
    • Ebeling P.R., and Burr D.B. Positive effects of intravenous zoledronic acid on bone remodeling and structure: are different effects on osteoblast activity to other oral bisphosphonates responsible?. J. Bone Miner. Res. 23 (2008) 2-5
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 2-5
    • Ebeling, P.R.1    Burr, D.B.2
  • 23
  • 24
    • 0027068097 scopus 로고
    • Bone resorption and formation on the periosteal envelope of the ilium: a histomorphometric study in healthy women
    • Balena R., Shih M.S., and Parfitt A.M. Bone resorption and formation on the periosteal envelope of the ilium: a histomorphometric study in healthy women. J. Bone Miner. Res. 7 (1992) 1475-1482
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 1475-1482
    • Balena, R.1    Shih, M.S.2    Parfitt, A.M.3
  • 25
    • 8444238558 scopus 로고    scopus 로고
    • Periosteum: biology, regulation, and response to osteoporosis therapies
    • Allen M.R., Hock J.M., and Burr D.B. Periosteum: biology, regulation, and response to osteoporosis therapies. Bone 35 (2004) 1003-1012
    • (2004) Bone , vol.35 , pp. 1003-1012
    • Allen, M.R.1    Hock, J.M.2    Burr, D.B.3
  • 26
    • 33750536911 scopus 로고    scopus 로고
    • Influence of alendronate on periosteal and endocortical bone formation in the ilium of osteoporotic women
    • Bare S., Recker S., Recker R., and Kimmel D. Influence of alendronate on periosteal and endocortical bone formation in the ilium of osteoporotic women. J. Bone Miner. Res. 20 (2005) SA414
    • (2005) J. Bone Miner. Res. , vol.20
    • Bare, S.1    Recker, S.2    Recker, R.3    Kimmel, D.4
  • 27
    • 0012574802 scopus 로고    scopus 로고
    • Effect of alendronate and estrogen replacement on periosteal bone formation in postmenopausal women
    • Recker R., Coble T., Burshell A., Lombardi A., Rodan G., Kimmel D., et al. Effect of alendronate and estrogen replacement on periosteal bone formation in postmenopausal women. J. Bone Miner. Res. 16 (2001) 1176
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1176
    • Recker, R.1    Coble, T.2    Burshell, A.3    Lombardi, A.4    Rodan, G.5    Kimmel, D.6
  • 28
    • 0034065559 scopus 로고    scopus 로고
    • Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib
    • Mashiba T., Hirano T., Turner C.H., Forwood M.R., Johnston C.C., and Burr D.B. Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J. Bone Miner. Res. 15 (2000) 613-620
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 613-620
    • Mashiba, T.1    Hirano, T.2    Turner, C.H.3    Forwood, M.R.4    Johnston, C.C.5    Burr, D.B.6
  • 29
    • 14644437231 scopus 로고    scopus 로고
    • Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib
    • Komatsubara S., Mori S., Mashiba T., Li J., Nonaka K., Kaji Y., et al. Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib. J. Bone Miner. Res. 19 (2004) 999-1005
    • (2004) J. Bone Miner. Res. , vol.19 , pp. 999-1005
    • Komatsubara, S.1    Mori, S.2    Mashiba, T.3    Li, J.4    Nonaka, K.5    Kaji, Y.6
  • 30
    • 33750549653 scopus 로고    scopus 로고
    • Anti-remodeling agents influence osteoblast activity differently in modeling- and remodeling-associated bone formation
    • Allen M.R., Follet H., Khurana M., and Burr D.B. Anti-remodeling agents influence osteoblast activity differently in modeling- and remodeling-associated bone formation. Calcif. Tissue Int. 79 (2006) 255-261
    • (2006) Calcif. Tissue Int. , vol.79 , pp. 255-261
    • Allen, M.R.1    Follet, H.2    Khurana, M.3    Burr, D.B.4
  • 31
    • 0031800273 scopus 로고    scopus 로고
    • Responses of trabecular and cortical bone turnover and bone mass and strength to bisphosphonate YH529 in ovariohysterectomized beagles with calcium restriction
    • Yoshida Y., Moriya A., Kitamura K., Inazu M., Okimoto N., Okazaki Y., et al. Responses of trabecular and cortical bone turnover and bone mass and strength to bisphosphonate YH529 in ovariohysterectomized beagles with calcium restriction. J. Bone Miner. Res. 13 (1998) 1011-1022
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 1011-1022
    • Yoshida, Y.1    Moriya, A.2    Kitamura, K.3    Inazu, M.4    Okimoto, N.5    Okazaki, Y.6
  • 32
    • 0028915931 scopus 로고
    • Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study
    • Lafage M.H., Balena R., Battle M.A., Shea M., Seedor J.G., Klein H., et al. Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study. J. Clin. Invest. 95 (1995) 2127-2133
    • (1995) J. Clin. Invest. , vol.95 , pp. 2127-2133
    • Lafage, M.H.1    Balena, R.2    Battle, M.A.3    Shea, M.4    Seedor, J.G.5    Klein, H.6
  • 33
    • 58649104171 scopus 로고    scopus 로고
    • Combination treatment with a selective androgen receptor modulator (SARM) and a bisphosphonate has additive effects in osteopenic female rats
    • Vajda E.G., Hogue A., Griffiths K.N., Chang W.Y., Burnett K., Chen Y., et al. Combination treatment with a selective androgen receptor modulator (SARM) and a bisphosphonate has additive effects in osteopenic female rats. J. Bone Miner. Res. 24 (2008) 231-240
    • (2008) J. Bone Miner. Res. , vol.24 , pp. 231-240
    • Vajda, E.G.1    Hogue, A.2    Griffiths, K.N.3    Chang, W.Y.4    Burnett, K.5    Chen, Y.6
  • 34
    • 33746992600 scopus 로고    scopus 로고
    • Comparative effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats
    • Iwamoto J., Seki A., Takeda T., Sato Y., Yamada H., and Yeh J.K. Comparative effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats. Exp. Anim. 55 (2006) 357-367
    • (2006) Exp. Anim. , vol.55 , pp. 357-367
    • Iwamoto, J.1    Seki, A.2    Takeda, T.3    Sato, Y.4    Yamada, H.5    Yeh, J.K.6
  • 35
  • 36
    • 0029082295 scopus 로고
    • Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats
    • Baumann B.D., and Wronski T.J. Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats. Bone 16 (1995) 247-253
    • (1995) Bone , vol.16 , pp. 247-253
    • Baumann, B.D.1    Wronski, T.J.2
  • 37
    • 35348885488 scopus 로고    scopus 로고
    • Risedronate did not block the maximal anabolic effect of PTH in aged rats
    • Yao W., Su M., Zhang Q., Tian X., Setterberg R.B., Blanton C., et al. Risedronate did not block the maximal anabolic effect of PTH in aged rats. Bone 41 (2007) 813-819
    • (2007) Bone , vol.41 , pp. 813-819
    • Yao, W.1    Su, M.2    Zhang, Q.3    Tian, X.4    Setterberg, R.B.5    Blanton, C.6
  • 38
    • 33747674263 scopus 로고    scopus 로고
    • The WNT co-receptor LRP5 is essential for skeletal mechanotransduction, but not for the anabolic bone response to parathyroid hormone treatment
    • Sawakami K., Robling A.G., Ai M., Pitner N.D., Liu D., Warden S.J., et al. The WNT co-receptor LRP5 is essential for skeletal mechanotransduction, but not for the anabolic bone response to parathyroid hormone treatment. J. Biol. Chem. 281 (2006) 63698-63711
    • (2006) J. Biol. Chem. , vol.281 , pp. 63698-63711
    • Sawakami, K.1    Robling, A.G.2    Ai, M.3    Pitner, N.D.4    Liu, D.5    Warden, S.J.6
  • 39
    • 36549072502 scopus 로고    scopus 로고
    • Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy
    • Russell R.G., Xia Z., Dunford J.E., Oppermann U., Kwaasi A., Hulley P.A., et al. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann. N. Y. Acad. Sci. 1117 (2007) 209-257
    • (2007) Ann. N. Y. Acad. Sci. , vol.1117 , pp. 209-257
    • Russell, R.G.1    Xia, Z.2    Dunford, J.E.3    Oppermann, U.4    Kwaasi, A.5    Hulley, P.A.6
  • 40
    • 33646089442 scopus 로고    scopus 로고
    • Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite
    • Nancollas G.H., Tang R., Phipps R.J., Henneman Z., Gulde S., Wu W., et al. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone (2006) 617-627
    • (2006) Bone , pp. 617-627
    • Nancollas, G.H.1    Tang, R.2    Phipps, R.J.3    Henneman, Z.4    Gulde, S.5    Wu, W.6
  • 41
    • 33748175899 scopus 로고    scopus 로고
    • Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate
    • Allen M.R., Iwata K., Phipps R., and Burr D.B. Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate. Bone 39 (2006) 872-879
    • (2006) Bone , vol.39 , pp. 872-879
    • Allen, M.R.1    Iwata, K.2    Phipps, R.3    Burr, D.B.4
  • 42
    • 36649036563 scopus 로고    scopus 로고
    • Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs
    • Allen M.R., and Burr D.B. Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs. Osteoporos. Int. 19 (2008) 95-99
    • (2008) Osteoporos. Int. , vol.19 , pp. 95-99
    • Allen, M.R.1    Burr, D.B.2
  • 43
    • 25844504632 scopus 로고    scopus 로고
    • Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies
    • Boonen S., Laan R.F., Barton I.P., and Watts N.B. Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies. Osteoporos. Int. 16 (2005) 1291-1298
    • (2005) Osteoporos. Int. , vol.16 , pp. 1291-1298
    • Boonen, S.1    Laan, R.F.2    Barton, I.P.3    Watts, N.B.4
  • 44
    • 0036862022 scopus 로고    scopus 로고
    • Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis
    • Eriksen E.F., Melsen F., Sod E., Barton I., and Chines A. Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone 31 (2002) 620-625
    • (2002) Bone , vol.31 , pp. 620-625
    • Eriksen, E.F.1    Melsen, F.2    Sod, E.3    Barton, I.4    Chines, A.5
  • 45
    • 0030868816 scopus 로고    scopus 로고
    • Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis
    • Chavassieux P.M., Arlot M.E., Reda C., Wei L., Yates A.J., and Meunier P.J. Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis. J. Clin. Invest. 100 (1997) 1475-1480
    • (1997) J. Clin. Invest. , vol.100 , pp. 1475-1480
    • Chavassieux, P.M.1    Arlot, M.E.2    Reda, C.3    Wei, L.4    Yates, A.J.5    Meunier, P.J.6
  • 46
    • 34547568211 scopus 로고    scopus 로고
    • Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis
    • Stepan J.J., Burr D.B., Pavo I., Sipos A., Michalska D., Li J., et al. Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women with osteoporosis. Bone 41 (2007) 378-385
    • (2007) Bone , vol.41 , pp. 378-385
    • Stepan, J.J.1    Burr, D.B.2    Pavo, I.3    Sipos, A.4    Michalska, D.5    Li, J.6
  • 48
    • 1642371153 scopus 로고    scopus 로고
    • Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study
    • Recker R.R., Weinstein R.S., Chesnut III C.H., Schimmer R.C., Mahoney P., Hughes C., et al. Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study. Osteoporos. Int. 15 (2004) 231-237
    • (2004) Osteoporos. Int. , vol.15 , pp. 231-237
    • Recker, R.R.1    Weinstein, R.S.2    Chesnut III, C.H.3    Schimmer, R.C.4    Mahoney, P.5    Hughes, C.6
  • 49
    • 0034906270 scopus 로고    scopus 로고
    • Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    • Roschger P., Rinnerthaler S., Yates J., Rodan G.A., Fratzl P., and Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29 (2001) 185-191
    • (2001) Bone , vol.29 , pp. 185-191
    • Roschger, P.1    Rinnerthaler, S.2    Yates, J.3    Rodan, G.A.4    Fratzl, P.5    Klaushofer, K.6


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