Imipenem heteroresistance: High prevalence among Enterobacteriaceae Klebsiella pneumoniae carbapenemase producers

Journal of Medical Microbiology

Volumn 64, Issue 1, 2015, Pages 124-126

  Nodari, Carolina Silva ^a,b   Barth, Afonso Luis ^a,b   Ribeiro, Vanessa Bley ^c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CARBAPENEMASE; IMIPENEM; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM ISOLATE; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; CONTROLLED STUDY; ENTEROBACTERIACEAE; ESCHERICHIA COLI; HETERORESISTANCE; KLEBSIELLA PNEUMONIAE; LETTER; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PREVALENCE; DRUG EFFECTS; ENTEROBACTERIACEAE INFECTION; ENZYMOLOGY; GENETIC VARIABILITY; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PHENOTYPE; SECRETION (PROCESS);

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; GENETIC VARIATION; HUMANS; IMIPENEM; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PHENOTYPE; PREVALENCE;

EID: 84919718933     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.081869-0     Document Type: Letter

References (17)

1. Alba, J., Ishii, Y., Thomson, K., Moland, E. S. & Yamaguchi, K. (2005). Kinetics study of KPC-3, a plasmid-encoded class A carbapenemhydrolyzing beta-lactamase. Antimicrob Agents Chemother 49, 4760-4762.
2. Anderson, K. F., Lonsway, D. R., Rasheed, J. K., Biddle, J., Jensen, B., McDougal, L. K., Carey, R. B., Thompson, A., Stocker, S. & other authors (2007). Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J Clin Microbiol 45, 2723-2725.
3. nd Informational Supplement M100-S22. Wayne, PA: Clinical and Laboratory Standards Institute.
4. Falagas, M. E., Makris, G. C., Dimopoulos, G. & Matthaiou, D. K. (2008). Heteroresistance: a concern of increasing clinical significance? Clin Microbiol Infect 14, 101-104.
5. Fernández Cuenca, F., Sánchez, M. C., Caballero-Moyano, F. J., Vila, J., Martínez-Martínez, L., Bou, G., Baño, J. R. & Pascual, A. (2012). Prevalence and analysis of microbiological factors associated with phenotypic heterogeneous resistance to carbapenems in Acinetobacter baumannii. Int J Antimicrob Agents 39, 472-477.
6. Ikonomidis, A., Neou, E., Gogou, V., Vrioni, G., Tsakris, A. & Pournaras, S. (2009). Heteroresistance to meropenem in carbapenemsusceptible Acinetobacter baumannii. J Clin Microbiol 47, 4055-4059.
7. Monteiro, J., Widen, R. H., Pignatari, A. C., Kubasek, C. & Silbert, S. (2012). Rapid detection of carbapenemase genes by multiplex real-time PCR. J Antimicrob Chemother 67, 906-909.
8. Nordmann, P., Cuzon, G. & Naas, T. (2009). The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9, 228-236.
9. Nordmann, P., Naas, T. & Poirel, L. (2011). Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17, 1791-1798.
10. Oikonomou, O., Panopoulou, M. & Ikonomidis, A. J. (2011). Investigation of carbapenem heteroresistance among different sequence types of Pseudomonas aeruginosa clinical isolates reveals further diversity. J Med Microbiol 60, 1556-1558.
11. Pitout, J. D. & Laupland, K. B. (2008). Extendedspectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis 8, 159-166.
12. Pournaras, S., Ikonomidis, A., Markogiannakis, A., Maniatis, A. N. & Tsakris, A. (2005). Heteroresistance to carbapenems in Acinetobacter baumannii. J Antimicrob Chemother 55, 1055-1056.
13. Pournaras, S., Ikonomidis, A., Markogiannakis, A., Spanakis, N., Maniatis, A. N. & Tsakris, A. (2007). Characterization of clinical isolates of Pseudomonas aeruginosa heterogeneously resistant to carbapenems. J Med Microbiol 56, 66-70.
14. Pournaras, S., Kristo, I., Vrioni, G., Ikonomidis, A., Poulou, A., Petropoulou, D. & Tsakris, A. (2010). Characteristics of meropenem heteroresistance in Klebsiella pneumoniae carbapenemase (KPC)-producing clinical isolates of K. pneumoniae. J Clin Microbiol 48, 2601-2604.
15. Ribeiro, V. B., Zavascki, A. P., Nodari, C. S., Sandri, A. M., Silva, M. P., Campos, J. C., Sampaio, J. L. & Barth, A. L. (2012). Detection of blaKPC-2 in a carbapenem-resistant Kluyvera georgiana. J Antimicrob Chemother 67, 2776-2777.
16. Tato, M., Morosini, M., García, L., Albertí, S., Coque, M. T. & Cantón, R. (2010). Carbapenem heteroresistance in VIM-1-producing Klebsiella pneumoniae isolates belonging to the same clone: consequences for routine susceptibility testing. J Clin Microbiol 48, 4089-4093.
17. Yigit, H., Queenan, A. M., Anderson, G. J., Domenech-Sanchez, A., Biddle, J. W., Steward, C. D., Alberti, S., Bush, K. & Tenover, F. C. (2001). Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenemresistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 45, 1151-1161.