Characteristics of meropenem heteroresistance in Klebsiella pneumoniae carbapenemase (KPC)-producing clinical isolates of K. pneumoniae

Journal of Clinical Microbiology

Volumn 48, Issue 7, 2010, Pages 2601-2604

  Pournaras, Spyros ^a   Kristo, Ioulia ^a   Vrioni, Georgia ^b   Ikonomidis, Alexandros ^a   Poulou, Aggeliki ^c   Petropoulou, Dimitra ^d   Tsakris, Athanassios ^b  

^a UNIVERSITY OF THESSALY   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c General District Hospital of Serres   (Greece)

^d Saint Panteleimon General Hospital   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEMASE; MEROPENEM; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; THIENAMYCIN DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BACTERIUM COLONY; BACTERIUM ISOLATE; GENE EXPRESSION; KLEBSIELLA PNEUMONIAE; NONHUMAN; PRIORITY JOURNAL; DRUG EFFECTS; GENETICS; HUMAN; KLEBSIELLA INFECTION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

KLEBSIELLA PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIENAMYCINS;

EID: 77954437585     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02134-09     Document Type: Article

References (22)

1. Alba, J., Y. Ishii, K. Thomson, E. S. Moland, and K. Yamaguchi. 2005. Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing β-lactamase. Antimicrob. Agents Chemother. 49:4760-4762.
2. Anderson, K. F., D. R. Lonsway, J. K. Rasheed, J. Biddle, B. Jensen, L. K. McDougal, R. B. Carey, A. Thompson, S. Stocker, B. Limbago, and J. B. Patel. 2007. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J. Clin. Microbiol. 45:2723-2725.
3. Bratu, S., D. Landman, R. Haag, R. Recco, A. Eramo, M. Alam, and J. Quale. 2005. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City. Arch. Intern. Med. 165:1430-1435.
4. Cai, J. C., H. W. Zhou, R. Zhang, and G. X. Chen. 2008. Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing β-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob. Agents Chemother. 52:2014-2018.
5. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing, 17th informational supplement. M100-S17. Clinical and Laboratory Standards Institute, Wayne, PA.
6. KPC-containing Klebsiella pneumoniae isolates detected in different institutions in the eastern USA. J. Antimicrob. Chemother. 63:427-437.
7. Girlich, D., L. Poirel, and P. Nordmann. 2009. CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli. Antimicrob. Agents Chemother. 53:832-834.
8. Ikonomidis, A., E. Neou, V. Gogou, G. Vrioni, A. Tsakris, and S. Pournaras. 2009. Heteroresistance to meropenem in carbapenem-susceptible Acinetobacter baumannii. J. Clin. Microbiol. 47:4055-4059.
9. Landman, D., S. Bratu, and J. Quale. 2009. Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae. J. Med. Microbiol. 58:1303-1308.
10. Lomaestro, B. M., E. H. Tobin, W. Shang, R. Recco, A. Eramo, M. Alam, and J. Quale. 2005. The spread of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae to upstate New York. Clin. Infect. Dis. 43:26-28.
11. Maniati, M., A. Ikonomidis, P. Mantzana, A. Daponte, A. N. Maniatis, and S. Pournaras. 2007. A highly carbapenem resistant Pseudomonas aeruginosa isolate with a novel blaVIM-4/blaP1b integron over-expresses two efflux pumps and lacks OprD. J. Antimicrob. Chemother. 60:132-135.
12. National Committee for Clinical Laboratory Standards. 1999. Methods for determining bactericidal activity of antimicrobial agents. Approved guideline M26-A. National Committee for Clinical Laboratory Standards, Wayne, PA.
13. Nordmann, P., G. Cuzon, and T. Naas. 2009. The real threat of Klebsiella pneumoniae carbapenemase producing bacteria. Lancet Infect. Dis. 9:228-236.
14. Pankuch, G. A., G. Lin, H. Seifert, and P. C. Appelbaum. 2008. Activity of meropenem with and without ciprofloxacin and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii. Antimicrob. Agents Chemother. 52:333-336.
15. Pillai, D. R., R. Melano, P. Rawte, S. Lo, N. Tijet, M. Fuksa, N. Roda, D. J. Farrell, and S. Krajden. 2009. Klebsiella pneumoniae carbapenemase, Canada. Emerg. Infect. Dis. 15:827-829.
16. Pournaras, S., A. Ikonomidis, A. Markogiannakis, N. Spanakis, A. N. Maniatis, and A. Tsakris. 2007. Characterisation of clinical isolates of Pseudomonas aeruginosa heterogeneously resistant to carbapenems. J. Med. Microbiol. 56:66-70.
17. Pournaras, S., E. Protonotariou, E. Voulgari, I. Kristo, E. Dimitroulia, D. Vitti, M. Tsalidou, A. N. Maniatis, A. Tsakris, and D. Sofianou. 2009. Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae in Greece. J. Antimicrob. Chemother. 64:348-352.
18. Samra, Z., O. Ofir, Y. Lishtzinsky, L. Madar-Shapiro, and J. Bishara. 2007. Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel. Int. J. Antimicrob. Agents. 30:525-529.
19. Tenover, F. C., R. K. Kalsi, P. P. Williams, R. B. Carey, S. Stocker, D. Lonsway, J. K. Rasheed, J. W. Biddle, J. E. McGowan, Jr., and B. Hanna. 2006. Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing. Emerg. Infect. Dis. 12:1209-1213.
20. Tsakris, A., I. Kristo, A. Poulou, K. Themeli-Digalaki, A. Ikonomidis, D. Petropoulou, S. Pournaras, and D. Sofianou. 2009. Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J. Clin. Microbiol. 47:362-367.
21. Woodford, N., J. Zhang, M. Warner, M. E. Kaufmann, J. Matos, A. Macdonald, D. Brudney, D. Sompolinsky, S. Navon-Venezia, and D. M. Livermore. 2008. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J. Antimicrob. Chemother. 62:1261-1264.
22. Yigit, H., A. M. Queenan, G. J. Anderson, A. Domenech-Sanchez, J. W. Biddle, C. D. Steward, S. Alberti, K. Bush, and F. C. Tenover. 2001. Novel carbapenem-hydrolyzing β-lactamase KPC-1 from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45:1151-1161.