Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A549 lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy

Biomaterials

Volumn 42, Issue , 2015, Pages 30-41

  Lu, Hsin Yi ^a,b   Chang, Ya Ju ^b   Fan, Nien Chu ^b   Wang, Li Sheng ^b   Lai, Nien Chu ^a   Yang, Chia Min ^a   Wu, Li Chen ^c   Ho, Ja an Annie ^a,b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL CHI NAN UNIVERSITY   (Taiwan)

Author keywords

Autophagy; Chemotherapy; Glutathione mediated intracellular release; Gold nanoparticles capping; Mesoporous silica nanohybrid; Oxidative stress strategy

Indexed keywords

BIOLOGICAL ORGANS; CELL DEATH; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; FIBER OPTIC SENSORS; GOLD NANOPARTICLES; METAL NANOPARTICLES; MITOCHONDRIA; NANOSTRUCTURED MATERIALS; OXIDATIVE STRESS; PEPTIDES; SILICA; SILICA NANOPARTICLES; TARGETED DRUG DELIVERY;

AUTOPHAGY; COMPETITIVE BINDING; GLUTATHIONES; GOLD NANOPARTICLES (GNPS); MESOPOROUS SILICA NANOPARTICLES; MITOCHONDRIA DYSFUNCTIONS; NANO HYBRIDS; NANO-DELIVERY SYSTEMS;

DISEASES;

AMINO FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLE; CAMPTOTHECIN; GLUTATHIONE; GOLD; GOLD NANOPARTICLE; GOLD NANOPARTICLE CAPPED MESOPOROUS SILICA NANOPARTICLE; NITROGEN; SILICA NANOPARTICLE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MALONALDEHYDE; NANOPARTICLE; SILICON DIOXIDE;

3T3 CELL LINE; A549 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; BINDING COMPETITION; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL LEVEL; CHEMICAL BINDING; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DELIVERY SYSTEM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; LUNG CANCER; MALE; MOUSE; MULTIPLE CYCLE TREATMENT; NANOFABRICATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARTICLE SIZE; THERAPY EFFECT; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENERGY METABOLISM; INTRACELLULAR SPACE; LIPID PEROXIDATION; METABOLISM; MITOCHONDRION; NEOPLASMS; NUDE MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; POROSITY; TUMOR CELL LINE; ULTRASTRUCTURE;

3T3-L1 CELLS; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AUTOPHAGY; CAMPTOTHECIN; CELL LINE, TUMOR; ENERGY METABOLISM; GLUTATHIONE; HUMANS; INTRACELLULAR SPACE; LIPID PEROXIDATION; MALONDIALDEHYDE; MICE; MICE, NUDE; MITOCHONDRIA; MODELS, BIOLOGICAL; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; POROSITY; SILICON DIOXIDE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919703762     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.11.029     Document Type: Article

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