GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo

Bioscience Reports

Volumn 34, Issue 6, 2014, Pages 841-850

  Zang, Shengbing ^a,b   Lin, Ting Yu ^a,c   Chen, Xinji ^a,b   Gencheva, Marieta ^a   Newo, Alain N S ^a   Yang, Lixin ^a   Rossi, Daniel ^a   Hu, Jianda ^b   Lin, Shwu Bin ^c   Huang, Aimin ^b   Lin, Ren Jang ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

DExD H box protein; G patch domain; KOW domain; RNA helicase; Spliceosome; Splicing factor

Indexed keywords

PROTEIN DHX16; PROTEIN GPKOW; RNA; RNA BINDING PROTEIN; RNA HELICASE; UNCLASSIFIED DRUG; DHX16 PROTEIN, HUMAN; GPKOW PROTEIN, HUMAN; PROTEIN BINDING; RNA PRECURSOR;

ARTICLE; CONTROLLED STUDY; G PATCH DOMAIN; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KOW1 DOMAIN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA SPLICING; SPLICEOSOME; SPLICING DEFECT; BINDING SITE; GEL MOBILITY SHIFT ASSAY; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MUTATION; TWO HYBRID SYSTEM; WESTERN BLOTTING;

ARABIDOPSIS; SACCHAROMYCES;

BINDING SITES; BLOTTING, WESTERN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEK293 CELLS; HELA CELLS; HUMANS; MUTATION; PROTEIN BINDING; RNA; RNA HELICASES; RNA PRECURSORS; RNA SPLICING; RNA-BINDING PROTEINS; SPLICEOSOMES; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84919699324     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20140142     Document Type: Article

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