Reinforcement learning deficits in people with schizophrenia persist after extended trials

Psychiatry Research

Volumn 220, Issue 3, 2014, Pages 760-764

  Cicero, David C ^a   Martin, Elizabeth A ^b   Becker, Theresa M ^c   Kerns, John G ^d  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Approach; Avoidance; Dopamine; Punishment; Reward

Indexed keywords

ADULT; ARTICLE; AVOIDANCE BEHAVIOR; BRIEF PSYCHIATRIC RATING SCALE; CONTINGENT VALUATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; LEARNING DISORDER; MAJOR CLINICAL STUDY; MALE; NEGATIVE FEEDBACK; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TEST; PHYSICAL ANHEDONIA SCORE; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE FEEDBACK; PROBABILISTIC SELECTION TASK; REINFORCEMENT; REVISED SOCIAL ANHEDONIA SCORE; REWARD; SCHIZOPHRENIA; STIMULUS RESPONSE; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TASK PERFORMANCE; ADAPTIVE BEHAVIOR; LEARNING; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

ADULT; FEEDBACK, PSYCHOLOGICAL; FEMALE; HUMANS; LEARNING; MALE; MIDDLE AGED; REINFORCEMENT (PSYCHOLOGY); REWARD; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84919687699     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2014.08.013     Document Type: Article

References (34)

1. Abi-Dargham A., Rodenhiser J., Printz D., Zea-Ponce Y., Gil R., Kegeles L.S., Weiss R., Cooper T.B., Mann J.J., Van Heertum R.L., Gorman J.M., Laruelle M. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:8104-8109. (doi: 97/14/8104).
2. Chapman L.J., Chapman J.P., Raulin M.L. Scales for physical and social anhedonia. Journal of Abnormal Psychology 1976, 85:374-382. 10.1037/0021-843x.85.4.374.
3. Corrigan P.W. Use of a token economy with seriously mentally ill patients: criticisms and misconceptions. Psychiatric Services 1995, 46(12):1258-1263.
4. Davis K.L., Kahn R.S., Ko G., Davidson M. Dopamine in schizophrenia: a review and reconceptualization. American Journal of Psychiatry 1991, 148:1474-1486.
5. Dickerson F.B., Tenhula W.N., Green-Paden L.D. The token economy for schizophrenia: review of the literature and recommendations for future research. Schizophrenia Research 2005, 75(2-3):405-416. 10.1016/j.schres.2004.08.026.
6. Doll, Bradley B., Jacobs, W. Jake, Sanfey, Alan G., Frank, Michael J., 2009. Instructional control of reinforcement learning: a behavioral and neurocomputational investigation. Brain Research 1299, 74-94. 10.1016/j.brainres.2009.07.007.
7. Dowd E.C., Barch D.M. Pavlovian reward prediction and receipt in schizophrenia: relationship to anhedonia. PLoS One 2012, 7(5):e35622. 10.1371/journal.pone.0035622.
8. Eckbald, M., Chapman, L. J., Chapman, J. P., Mishlove, M., 1982. The revised social anhedonia scale. (Available from L.J. Chapman, Department of Psychology, 1202 West Johnson Street, University of Wisconsin, Madison, WI 53706).
9. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders 1998, New York State Psychiatric Institute, New York.
10. Frank M.J., Claus E.D. Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. Psychological Review 2006, 113(2):300-326. 10.1037/0033-295X.113.2.300.
11. Frank M.J., Seeberger L.C., O'Reilly R C. By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 2004, 306(5703):1940-1943. 10.1126/science.1102941.
12. Gold J.M., Waltz J.A., Matveeva T.M., Kasanova Z., Strauss G.P., Herbener E.S., Collins A.G., Frank M.J. Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence. Archives of General Psychiatry 2012, 69(2):129-138. (doi: 69/2/129 [pii] 10.1001/archgenpsychiatry.2011.1269).
13. Gold J.M., Waltz J.A., Prentice K.J., Morris S.E., Heerey E.A. Reward processing in schizophrenia: a deficit in the representation of value. Schizophrenia Bulletin 2008, 34(5):835-847. 10.1093/schbul/sbn068.
14. Guillin O., Abi-Dargham A., Laruelle M. Neurobiology of dopamine in schizophrenia. International Review of Neurobiology 2007, 78:1-39. 10.1016/S0074-7742(06)78001-1.
15. Heinz A., Schlagenhauf F. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophrenia Bulletin 2010, 36(3):472-485. 10.1093/schbul/sbq031.
16. Hodges J.R. Cognitive Assessment for Clinicians 1994, Oxford University Press, Oxford.
17. Howes O.D., Kapur S. The dopamine hypothesis of schizophrenia: version III--the final common pathway. Schizophrenia Bulletin 2009, 35(3):549-562. 10.1093/schbul/sbp006.
18. Laruelle M., Abi-Dargham A. Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies. Journal of Psychopharmacology 1999, 13:358-371. 10.1177/026988119901300405.
19. Manning V., Wanigaratne S., Best D., Strathdee G., Schrover I., Gossop M. Screening for cognitive functioning in psychiatric outpatients with schizophrenia, alcohol dependence, and dual diagnosis. Schizophrenia Research 2007, 91(1-3):151-158. 10.1016/j.schres.2006.11.019.
20. McMahon R.P., Kelly D.L., Kreyenbuhl J., Kirkpatrick B., Love R.C., Conley R.R. Novel factor-based symptom scores in treatment resistant schizophrenia: implications for clinical trials. Neuropsychopharmacology 2002, 26(4):537-545. 10.1016/S0893-133X(01)00387-6.
21. Morris S.E., Heerey E.A., Gold J.M., Holroyd C.B. Learning-related changes in brain activity following errors and performance feedback in schizophrenia. Schizophrenia Research 2008, 99(1-3):274-285. 10.1016/j.schres.2007.08.027.
22. Overall J.E., Gorham D.R. The Brief Psychiatric Rating Scale. Psychological Reports 1962, 10:799-803.
23. Seeman P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1987, 1:133-152. 10.1002/syn.890010203.
24. Somlai Z., Moustafa A.A., Keri S., Myers C.E., Gluck M.A. General functioning predicts reward and punishment learning in schizophrenia. Schizophrenia Research 2011, 127(1-3):131-136. 10.1016/j.schres.2010.07.028.
25. Strauss G.P., Frank M.J., Waltz J.A., Kasanova Z., Herbener E.S., Gold J.M. Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia. Biological Psychiatry 2011, 69(5):424-431. 10.1016/j.biopsych.2010.10.015.
26. Tombaugh T.N., McDowell I., Kristjansson B., Hubley A.M. Mini-Mental State Examination and the modified MMSE: psychometric comparison and normative data. Psychological Assessment 1996, 1:48-59.
27. Tombaugh T.N., McIntyre N.J. The mini-mental state examination: a comprehensive review. Journal of the American Geriatrics Society 1992, 40:922-935.
28. Waltz J.A., Frank M.J., Robinson B.M., Gold J.M. Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biological Psychiatry 2007, 62(7):756-764. 10.1016/j.biopsych.2006.09.042.
29. Waltz J.A., Frank M.J., Wiecki T.V., Gold J.M. Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modeling. Neuropsychology 2011, 25(1):86-97. 10.1037/a0020882.
30. Waltz J.A., Gold J.M. Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction. Schizophrenia Research 2007, 93(1-3):296-303. 10.1016/j.schres.2007.03.010.
31. Weiler J.A., Bellebaum C., Brune M., Juckel G., Daum I. Impairment of probabilistic reward-based learning in schizophrenia. Neuropsychology 2009, 23(5):571-580. 10.1037/a0016166.
32. Zanarini M.C., Frankenburg F.R. Attainment and maintenance of reliability of axis I and II disorders over the course of a longitudinal study. Comprehensive Psychiatry 2001, 42(5):369-374. 10.1053/comp.2001.24556.
33. Zanarini M.C., Skodol A.E., Bender D., Dolan R., Sanislow C., Schaefer E., Morey L.C., Grilo C.M., Shea M.T., McGlashan T.H., Gunderson J.G. The Collaborative Longitudinal Personality Disorders Study: reliability of axis I and II diagnoses. Journal of Personality Disorders 2000, 14(4):291-299.
34. Ziauddeen H., Murray G.K. The relevance of reward pathways for schizophrenia. Current Opinion in Psychiatry 2010, 23(2):91-96. 10.1097/YCO.0b013e328336661b.