General functioning predicts reward and punishment learning in schizophrenia

Schizophrenia Research

Volumn 127, Issue 1-3, 2011, Pages 131-136

  Somlai, Zsuzsanna ^a   Moustafa, Ahmed A ^b   Kéri, Szabolcs ^c,d   Myers, Catherine E ^e,f   Gluck, Mark A ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b RUTGERS UNIVERSITY   (United States)

^c National Psychiatry Center   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e Neurobehavioral Research Laboratory   (United States)

^f RUTGERS UNIVERSITY   (United States)

Author keywords

General functioning; Positive and negative symptoms; Reinforcement learning; Reward; Schizophrenia

Indexed keywords

AMISULPRIDE; ARIPIPRAZOLE; CHLORPROMAZINE; CLOZAPINE; FLUPENTIXOL; HALOPERIDOL; OLANZAPINE; QUETIAPINE; RISPERIDONE; SERTINDOLE;

ADULT; ARTICLE; CLASSIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; LEARNING DISORDER; MALE; MENTAL TASK; NEGATIVE SYNDROME; PATIENT EDUCATION; POSITIVE SYNDROME; PREDICTION; PRIORITY JOURNAL; REINFORCEMENT; SCHIZOPHRENIA; SOCIAL INTERACTION; SOCIOPATHY; SYMPTOM; TASK PERFORMANCE;

ADULT; ANALYSIS OF VARIANCE; FEMALE; HUMANS; LEARNING DISORDERS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PUNISHMENT; REWARD; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 79952316450     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2010.07.028     Document Type: Article

References (40)

1. American Psychiatric Association DSM-IV: Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, Washington, DC. fourth ed.
2. Aron A.R., Shohamy D., Clark J., Myers C., Gluck M.A., Poldrack R.A. Human midbrain sensitivity to cognitive feedback and uncertainty during classification learning. J. Neurophysiol. 2004, 92(2):1144-1152.
3. Beninger R.J., Wasserman J., Zanibbi K., Charbonneau D., Mangels J., Beninger B.V. Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation. Schizophr. Res. 2003, 61(2-3):281-292.
4. Bódi N., Kéri S., Nagy H., Moustafa A., Myers C.E., Daw N., Dibó G., Takáts A., Bereczki D., Gluck M.A. Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients. Brain 2009, 132(9):2385-1395.
5. Dickerson F.B., Tenhula W.N., Green-Paden L.D. The token economy for schizophrenia: review of the literature and recommendations for future research. Schizophr. Res. 2005, 75(2-3):405-416.
6. Drew M.R., Simpson E.H., Kellendonk C., Herzberg W.G., Lipatova O., Fairhurst S., Kandel E.R., Malapani C., Balsam P.D. Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J. Neurosci. 2007, 27(29):7731-7739.
7. Farkas M., Polgár P., Kelemen O., Réthelyi J., Bitter I., Myers C.E., Gluck M.A., Kéri S. Associative learning in deficit and nondeficit schizophrenia. NeuroReport 2008, 19(1):55-58.
8. Foerde K., Poldrack R.A., Khan B.J., Sabb F.W., Bookheimer S.Y., Bilder R.M., Guthrie D., Granholm E., Nuechterlein K.H., Marder S.R., Asarnow R.F. Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learning. Neuropsychology 2008, 22(1):100-109.
9. Gold J.M., Waltz J.A., Prentice K.J., Morris S.E., Heerey E.A. Reward processing in schizophrenia: a deficit in the representation of value. Schizophr. Bull. 2008, 34(5):835-847.
10. Gold J.M., Hahn B., Strauss G.P., Waltz J.A. Turning it upside down: areas of preserved cognitive function in schizophrenia. Neuropsychol. Rev. 2009, 19(3):294-311.
11. Green M.F., Kern R.S., Heaton R.K. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr. Res. 2004, 72(1):41-51.
12. Harris M.S., Wiseman C.L., Reilly J.L., Keshavan M.S., Sweeney J.A. Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia. Neuropsychopharmacology 2009, 34(2):468-476.
13. Horan W.P., Green M.F., Knowlton B.J., Wynn J.K., Mintz J., Nuechterlein K.H. Impaired implicit learning in schizophrenia. Neuropsychology 2008, 22(5):606-617.
14. Juckel G., Schlagenhauf F., Koslowski M., Wüstenberg T., Villringer A., Knutson B., Wrase J., Heinz A. Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage 2006, 29(2):409-416.
15. Juckel G., Schlagenhauf F., Koslowski M., Filonov D., Wüstenberg T., Villringer A., Knutson B., Kienast T., Gallinat J., Wrase J., Heinz A. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl.) 2006, 187(2):222-228.
16. Kapur S., Mizrahi R., Li M. From dopamine to salience to psychosis - linking biology, pharmacology and phenomenology of psychosis. Schizophr. Res. 2005, 79(1):59-68.
17. Kawakubo Y., Rogers M.A., Kasai K. Procedural memory predicts social skills in persons with schizophrenia. J. Nerv. Ment. Dis. 2006, 194(8):625-627.
18. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987, 13(2):261-276.
19. Keefe R.S. Cognitive deficits in patients with schizophrenia: effects and treatment. J. Clin. Psychiatry 2007, 68(Suppl 14):8-13.
20. Kéri S., Kelemen O., Szekeres G., Bagóczky N., Erdélyi R., Antal A., Benedek G., Janka Z. Schizophrenics know more than they can tell: probabilistic classification learning in schizophrenia. Psychol. Med. 2000, 30(1):149-155.
21. Kéri S., Nagy O., Kelemen O., Myers C.E., Gluck M.A. Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia. Schizophr. Res. 2005, 77(2-3):321-328.
22. Koch K., Schachtzabel C., Wagner G., Schikora J., Schultz C., Reichenbach J.R., Sauer H., Schlösser R.G. Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia. Neuroimage 2010, 50(1):223-232.
23. Laviolette S.R., Lauzon N.M., Bishop S.F., Sun N., Tan H. Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity. J. Neurosci. 2008, 28(32):8025-8033.
24. Murray G.K., Cheng F., Clark L., Barnett J.H., Blackwell A.D., Fletcher P.C., Robbins T.W., Bullmore E.T., Jones P.B. Reinforcement and reversal learning in first-episode psychosis. Schizophr. Bull. 2008, 34(5):848-855.
25. Murray G.K., Corlett P.R., Clark L., Pessiglione M., Blackwell A.D., Honey G., Jones P.B., Bullmore E.T., Robbins T.W., Fletcher P.C. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol. Psychiatry 2008, 13(3):267-276. 239.
26. Pessiglione M., Seymour B., Flandin G., Dolan R.J., Frith C.D. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 2006, 442(7106):1042-1045.
27. Polgár P., Farkas M., Nagy O., Kelemen O., Réthelyi J., Bitter I., Myers C.E., Gluck M.A., Kéri S. How to find the way out from four rooms? The learning of "chaining" associations may shed light on the neuropsychology of the deficit syndrome of schizophrenia. Schizophr. Res. 2008, 99(1-3):200-207.
28. Schlagenhauf F., Sterzer P., Schmack K., Ballmaier M., Rapp M., Wrase J., Juckel G., Gallinat J., Heinz A. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol. Psychiatry 2009, 65(12):1032-1039.
29. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 1998, 59(suppl. 20):22-33.
30. Shohamy D., Mihalakos P., Chin R., Thomas B., Wagner A.D., Tamminga C. Learning and generalization in schizophrenia: effects of disease and antipsychotic drug treatment. Biol. Psychiatry 2010, 67(10):926-932.
31. Silverstein S.M., Spaulding W.D., Menditto A.A., Savitz A., Liberman R.P., Berten S., Starobin H. Attention shaping: a reward-based learning method to enhance skills training outcomes in schizophrenia. Schizophr. Bull. 2009, 35(1):222-232.
32. Simon J.J., Biller A., Walther S., Roesch-Ely D., Stippich C., Weisbrod M., Kaiser S. Neural correlates of reward processing in schizophrenia - relationship to apathy and depression. Schizophr. Res. 2010, 118(1-3):154-161.
33. Waltz J.A., Gold J.M. Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction. Schizophr. Res. 2007, 93(1-3):296-303.
34. Waltz J.A., Frank M.J., Robinson B.M., Gold J.M. Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction. Biol. Psychiatry 2007, 62(7):756-764.
35. Waltz J.A., Schweitzer J.B., Gold J.M., Kurup P.K., Ross T.J., Salmeron B.J., Rose E.J., McClure S.M., Stein E.A. Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. Neuropsychopharmacology 2009, 34(6):1567-1577.
36. Weickert T.W., Terrazas A., Bigelow L.B., Malley J.D., Hyde T., Egan M.F., Weinberger D.R., Goldberg T.E. Habit and skill learning in schizophrenia: evidence of normal striatal processing with abnormal cortical input. Learn. Mem. 2002, 9(6):430-442.
37. Weickert T.W., Goldberg T.E., Callicott J.H., Chen Q., Apud J.A., Das S., Zoltick B.J., Egan M.F., Meeter M., Myers C., Gluck M.A., Weinberger D.R., Mattay V.S. Neural correlates of probabilistic category learning in patients with schizophrenia. J. Neurosci. 2009, 29(4):1244-1254.
38. Weiler J.A., Bellebaum C., Brüne M., Juckel G., Daum I. Impairment of probabilistic reward-based learning in schizophrenia. Neuropsychology 2009, 23(5):571-580.
39. Woods S.W. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J. Clin. Psychiatry 2003, 64(6):663-667.
40. Yip S.W., Sacco K.A., George T.P., Potenza M.N. Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance. Schizophr. Res. 2009, 110(1-3):156-164.